Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of medical compound with amidine skeleton in resisting plant pathogenic bacteria

A technology of phytopathogenic bacteria, compounds, applied in the fields of plant growth regulators, botanical equipment and methods, chemicals for biological control, etc., can solve problems such as damage, decline in quality and yield of agricultural products, and income reduction of agricultural practitioners , to achieve the effect of easy availability of raw materials and excellent antibacterial activity

Pending Publication Date: 2022-03-01
LANZHOU UNIVERSITY
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Phytopathogenic bacteria cause enormous damage to food crops, resulting in a significant decline in the quality and yield of agricultural products
The income of agricultural practitioners will also be cut accordingly

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of medical compound with amidine skeleton in resisting plant pathogenic bacteria
  • Application of medical compound with amidine skeleton in resisting plant pathogenic bacteria
  • Application of medical compound with amidine skeleton in resisting plant pathogenic bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Compounds 1-8 are commercially purchased, and their CAS numbers and purity are: (1) Chlorhexenidine hydrochloride, CAS: 25875-51-8, purity: 98%; (2) Polyhexamethylene biguanide , CAS: 27083-27-8, purity: 98%; (3) chlorhexidine acetate, CAS: 206986-79-0, purity: 98%; (4) imidazolium dipropionate, CAS: 55750-06 -6. Purity: 95%; (5) Diacetamide Triazamide, CAS: 908-54-3, Purity: 99%; (6) Triazamide, CAS: 536-71-0, Purity: 99% (7) pentamidine, CAS: 100-33-4, purity: 98%; (8) phenformin hydrochloride, CAS: 834-28-6, purity: 97%.

Embodiment 2

[0011] Embodiment 2: the medical compound with amidine skeleton, its structural formula is as follows:

[0012]

Embodiment 3

[0013] Embodiment 3: the anti-phytopathogenic bacteria activity assay of the medicinal compound with amidines skeleton

[0014] The strains used in this experiment were those frozen in the laboratory at -80°C with 30% glycerol. Take out the frozen strains and put them in the NB solid medium of agricultural bacteria (beef extract: 3g, peptone: 5g, yeast powder: 1g, sucrose: 10g, agar: 15g, distilled water: 1L, pH7.0; sterilized at 121℃ 20 min) to streak above, and incubate at a constant temperature at 28°C until a single colony grows. Pick a single colony from the solid medium to the Agrobacterium NB liquid medium (beef extract: 3g, peptone: 5g, yeast powder: 1g, sucrose: 10g, distilled water: 1L; sterilize at 121°C for 20min) at 28°C, 180rpm Constant temperature shaker shake culture to logarithmic growth phase. Dilute the strains in the logarithmic growth phase to about 10 with the corresponding liquid medium 6 CFU / mL for use. The compounds were respectively dissolved in D...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicinal chemistry, and discloses an application of a medical compound with an amidine skeleton in prevention and treatment of plant bacterial diseases caused by a rice bacterial leaf blight pathogenic bacterium Xanthomonas oryzae ACCC 11602, a citrus canker pathogenic bacterium Xanthomonas axonophora pv.Citri and a potato black shank pathogenic bacterium Pectobacterium atrosepticaACCC 19901. The invention further discloses a preparation method of the medical compound with the amidine skeleton, and application of the medical compound with the amidine skeleton in prevention and treatment of the plant bacterial diseases caused by the rice bacterial leaf blight pathogenic bacterium Xanthomonas oryzae ACCC 11602, the citrus canker pathogenic bacterium Xanthomonas axonophora pv.Citri and the potato black shank pathogenic bacterium Pectobacterium atrosepticaACCC 19901. The compound has the characteristics of easiness in obtaining, low cost, wide bactericidal spectrum and the like, and has further research and development values.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry and discloses the use of a medical compound with an amidine skeleton in preventing and treating plant bacterial diseases. Background technique [0002] At present, the infection of plant pathogenic bacteria occurs all over the world, especially the diseases caused by rice bacterial blight pathogen, citrus canker pathogen and potato blackleg pathogen are more serious. Phytopathogenic bacteria cause enormous damage to food crops, resulting in a substantial decline in the quality and yield of agricultural products. The income of agricultural practitioners will also be cut accordingly. Therefore, there is an urgent need to actively explore fungicides with a broad bactericidal spectrum and new targets to resist the infection of plant pathogenic bacteria. [0003] Compounds with amidine skeletons are the key structural units of bioactive molecules commonly used in agriculture and chemical industry. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N47/30A01N37/52A01P1/00
CPCA01N47/44A01N47/30A01N37/52
Inventor 刘映前罗雄飞马越贺颖慧周勇张保琪张智军安俊霞丁艳艳王艺荣朱丽菹
Owner LANZHOU UNIVERSITY