Soft tissue filler and preparation method thereof
A filling and soft tissue technology, applied in the field of soft tissue filling and its preparation, can solve the problems of short duration, stiff facial expression, etc., and achieve the effect of helping repair, preventing rejection, and improving recovery speed
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0034] In order to solve the above technical problems, the present application also provides a soft tissue filler preparation method, see figure 1 . figure 1 It is a schematic flowchart of a method for preparing a soft tissue filler according to an embodiment of the present application. It should be noted that if there are substantially the same results, this example does not refer to figure 1 The flow sequence shown is limited. Such as figure 1 As shown, the method includes:
[0035] Step 110: dissolving the bone-derived small molecule peptide in chloroform to prepare a bone-derived small molecule peptide solution.
[0036] Specifically, after dissolving 5-9 parts of the bone-derived small molecule peptide in chloroform, stirring and mixing until the bone-derived small molecule peptide is completely dissolved, a bone-derived small molecule peptide solution with a mass fraction of 20%-30% is prepared.
[0037] In one embodiment, the preparation method of small bone-derive...
Embodiment 1
[0050] The pretreated fish bones are crushed and treated with protease for 6-8 hours. After the treatment, the enzyme is inactivated to obtain the supernatant; the supernatant is filtered through an ultrafiltration membrane to obtain an active peptide with a molecular weight of no more than 5000Da. The protease is one of alkaline protease, neutral protease and animal protease. The method of inactivating the enzyme is heating to 100°C for 10 minutes. The pretreatment includes steps such as impurity removal, cleaning, and crushing.
Embodiment 2
[0052] After dissolving 5 parts of bone-derived small molecule peptides in chloroform, stirring and mixing until the bone-derived small molecule peptides were completely dissolved, a 20% bone-derived small molecule peptide solution was prepared. Add 20 parts of caprolactone monomer to the bone-derived small molecule peptide solution, stir and mix evenly, then add catalyst to it, place the reaction system under microwave irradiation, the power of microwave irradiation is 720W, under the catalysis of the catalyst, bone The source small molecule peptide and the caprolactone monomer were polymerized for 320 minutes to obtain bone-derived small molecule peptide-modified polycaprolactone, and after purification, a bone-derived small molecule peptide-polycaprolactone polymer solution was obtained. 22 parts of polyvinyl alcohol, 41 parts of osmotic pressure regulator, 46 parts of PBS buffered saline, 5 parts of viscosity modifier and 40 parts of calcium phosphate microspheres were unif...
PUM
| Property | Measurement | Unit |
|---|---|---|
| diameter | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More