Layer-by-layer deposited antibacterial healing-promoting soluble microneedle patch and preparation method thereof

A soluble, micro-needle sticker technology, applied in micro-needle, antibacterial, antifungal and other directions, can solve the problems of needle body retention, single component, easy needle breakage, etc., to reduce dosage, improve mechanical properties, reduce The effect of drug resistance

Pending Publication Date: 2022-03-15
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solid microneedles are made of metal or non-degradable polymers. The disadvantage is that the needles are prone to breakage, and there are certain safety hazards when the needles stay in the skin.
The problem with coated microneedles is that the drug on the coating surface reduces the sharpness of the microneedle tip, increases the friction between the needle body and the skin, and easily leads to incomplete insertion of the microneedle
Invention patent CN109010257A discloses the preparation of a multilayer soluble micron

Method used

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  • Layer-by-layer deposited antibacterial healing-promoting soluble microneedle patch and preparation method thereof
  • Layer-by-layer deposited antibacterial healing-promoting soluble microneedle patch and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0021] Such as figure 1 It is shown, in the preparation of the present invention to promote healing of soluble antimicrobial microneedle patch, comprising the steps of:

[0022] (1) Moisture Cuyu configuration precursor solution: After the sodium alginate was added to the deionized water of 70 ~ 80 ℃, stir until completely dissolved, until the solution temperature was reduced to 40 ℃, hyaluronic acid was added, sufficiently stirred until the solution clarified liquid precursor obtained Cuyu A moisturizer;

[0023] (2) Configuration antibacterial anti-inflammatory layer solution: when polyvinyl alcohol is added to the deionized water of 90 ~ 95 ℃, stirred to dissolution to a homogeneous solution, until the solution temperature was reduced to 50 ~ 60 ℃, quaternized chitosan were added salts, polyhexamethylene guanidine hydrochloride and gelatin mixed solution was sufficiently stirred until uniform, to obtain anti-bacterial anti-inflammatory precursor solution B;

[0024] (3) layer b...

Example Embodiment

[0026] Example 1

[0027] A method of preparing an antimicrobial layer by layer deposition Cuyu soluble microneedle patch, said method comprising the steps of:

[0028] (1) Moisture Cuyu configuration precursor solution: 2 parts of the sodium alginate was added to 70 ~ 80 ℃ of deionized water, stir until completely dissolved, until the solution temperature was reduced after 40 ℃, 5 parts of hyaluronic acid, sufficient stirring until the solution is clear, liquid precursor obtained Cuyu A moisturizer;

[0029] (2) Configuration antibacterial anti-inflammatory layer solution: when the polyvinyl alcohol was added to 6 parts of deionized water of 90 ~ 95 ℃, stirred to dissolution to a homogeneous solution, until the solution temperature was reduced to 50 ~ 60 ℃, were added 5 parts of the housing glycan quaternary ammonium salt, 2 parts of polyhexamethylene guanidine hydrochloride and 1 part of gelatin solution was sufficiently stirred until uniformly mixed, an antimicrobial-inflammato...

Example Embodiment

[0032] Example 2

[0033] (1) Moisture Cuyu configuration precursor solution: 2 parts of the sodium alginate was added to 70 ~ 80 ℃ of deionized water, stir until completely dissolved, until the solution temperature was reduced after 40 ℃, hyaluronic acid was added 6 parts of fully stirring until the solution is clear, liquid precursor obtained Cuyu A moisturizer;

[0034] (2) Configuration antibacterial anti-inflammatory layer solution: When 4 parts of polyvinyl alcohol was added to the deionized water of 90 ~ 95 ℃, stirred to dissolution to a homogeneous solution, until the solution temperature was reduced to 50 ~ 60 ℃, were added 6 parts of the housing glycans quaternary ammonium, 3 parts of polyhexamethylene guanidine hydrochloride and 1 part of gelatin solution was sufficiently stirred until uniformly mixed, an antimicrobial-inflammatory precursor solution B;

[0035](3) Preparation of a layer-by-layer deposition of antimicrobial initiation: 0.2 ml of pre-prolificing liquid A...

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Abstract

The invention discloses a preparation method of a layer-by-layer deposition antibacterial healing-promoting soluble microneedle patch, a microneedle belongs to the field of microneedle preparation methods, and the adopted preparation method is a layer-by-layer deposition micro-molding method. The preparation method has the advantage that materials which cannot be used together due to chemical reaction caused by blending can be used together. According to the antibacterial and healing-promoting soluble microneedle patch, the healing-promoting moisturizing layer is used as a needle tip, the antibacterial and anti-inflammatory layer is deposited on the needle tip, finally, the healing-promoting moisturizing layer is deposited, a functional layer is prepared, and a TPU medical adhesive tape is used as a backing layer. Wherein the healing promoting and moisturizing layer contains the following components: hyaluronic acid and sodium alginate. The antibacterial and anti-inflammatory layer comprises the following components: chitosan quaternary ammonium salt, gelatin, polyhexamethylene guanidine hydrochloride and polyvinyl alcohol. According to the invention, the excellent healing-promoting and moisturizing effects of polyanion polysaccharide and the excellent antibacterial and anti-inflammatory properties of polycation are deposited layer by layer, so that the healing-promoting, moisturizing, antibacterial and anti-inflammatory effects are synchronously carried out.

Description

technical field [0001] The invention belongs to the field of microneedle preparation methods, and in particular relates to a preparation method for layer-by-layer deposition of antibacterial and healing-promoting soluble microneedle patches. Background technique [0002] Microneedle is a new type of transdermal drug delivery technology, which consists of micron-scale fine needle tips arranged on the backing in an array, which can just pass through the stratum corneum of the skin without touching the pain nerve, and forms a drug delivery system on the skin surface. Channels allow drugs or natural antibacterial substances to reach the specified depth of the skin and enter the subcutaneous capillary network to be absorbed, which promotes the penetration of drugs and natural antibacterial substances without causing pain and destructive damage to the skin. Therefore, microneedles help to improve the drug absorption and the patient's compliance with natural antibacterial substance...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/00A61K31/785A61K47/32A61K47/42A61P17/00A61P31/04A61P31/10A61K31/722A61K31/728A61K31/734
CPCA61M37/0015A61K9/0021A61K31/785A61K31/722A61K31/728A61K31/734A61K47/32A61K47/42A61P31/04A61P31/10A61P17/00A61M2037/0053A61M2037/0046A61K2300/00
Inventor 高光辉陈颖
Owner CHANGCHUN UNIV OF TECH
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