Application of EGFR (epidermal growth factor receptor) inhibitor and anti-angiogenesis medicine in medicine for treating tumor diseases

An inhibitor and anti-vascular technology, applied in the field of medicine, can solve the problems of drug resistance and no clinical treatment plan in patients with non-small cell lung cancer

Pending Publication Date: 2022-03-18
SHANGHAI HANSOH BIOMEDICAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, regardless of the first-generation EGFR inhibitors represented by Gefitnib, the second-generation EGFR inhibitors represented by Afatinib, and the third-generation EGFR inhibitors represented by Osimertinb (AZD9291), after long-term clinical use in non- Drug resistance emerges in patients with small cell lung cancer
At present, there is no good clinical treatment plan for the above-mentioned drug-resistant patients

Method used

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  • Application of EGFR (epidermal growth factor receptor) inhibitor and anti-angiogenesis medicine in medicine for treating tumor diseases
  • Application of EGFR (epidermal growth factor receptor) inhibitor and anti-angiogenesis medicine in medicine for treating tumor diseases
  • Application of EGFR (epidermal growth factor receptor) inhibitor and anti-angiogenesis medicine in medicine for treating tumor diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] 1. Purpose of the experiment:

[0091] To evaluate the experimental therapeutic effect of Almonertinib combined with anti-angiogenic drug BP102 (bevacizumab biosimilar) on human lung cancer PC-9 xenografts in nude mice.

[0092] 2. Experimental materials:

[0093] 2.1 Test drug:

[0094] Drug A: Almonertinib (the mesylate salt of the compound of formula (I)), prepared according to the method disclosed in WO2017161937, and pH 4.18 acetate buffer is used for drug preparation;

[0095] Drug B: bevacizumab biosimilar (BP102), injection, Suzhou Shengdia Biomedical Co., Ltd.

[0096] 2.2 Experimental reagents:

[0097] PC-9 cells were purchased from Guangzhou Geneo Biotechnology Co., Ltd. 150cm 2 The culture flask adheres to the wall, and the culture condition is RPMI1640 medium plus 10% fetal bovine serum and 1% streptomycin / penicillin, at 37 ° C, containing 5% CO 2 cultured in an air incubator. Subculture 1-2 times a week, when the cells are in the exponential growth...

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Abstract

The invention provides an application of an EGFR (epidermal growth factor receptor) inhibitor and an anti-angiogenesis medicine in a medicine for treating tumor diseases. Specifically, the invention provides an application of a human epidermal growth factor receptor inhibitor (EGFRi) combined anti-angiogenesis medicine in a medicine for preventing or treating tumor diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of EGFR inhibitors and anti-angiogenesis drugs in drugs for treating tumor diseases. Background technique [0002] Worldwide, lung cancer has become the main cause of cancer death, and its morbidity and mortality are on the rise. In 2012, there were about 1.8 million new cases of lung cancer in the world. However, by 2018, the number of diagnosed cases of lung cancer in the world increased to 2.1 million. In China, in terms of incidence rate, statistics from the China Cancer Center show that lung cancer ranks first in the country, with about 781,000 cases per year, accounting for 20.55% of all types of cancer; in terms of mortality, lung cancer, liver cancer, gastric cancer , Esophageal cancer is the main cause of death of tumors. Despite the introduction of newer generations of cytotoxic drugs and targeted therapies over the past 20 years, treatment options and survival in patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/506A61K39/395A61P35/00A61P35/02
CPCA61K45/06A61K31/506A61K39/3955A61P35/00A61P35/02A61K2039/545A61K2300/00
Inventor 周远锋张晓婷
Owner SHANGHAI HANSOH BIOMEDICAL
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