High-bioavailability turmeric composition and preparation method thereof

A technology of availability and composition, which is applied in the field of high bioavailability turmeric composition and its preparation, can solve the core problems of curcuminoid components dissolution and unsatisfactory bioavailability, low bioavailability of curcuminoid components and Technical difficulties and other issues, to achieve the effect of good solubility and stability, simple production equipment requirements, and high bioavailability

Pending Publication Date: 2022-03-22
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the solubilization treatment technology for turmeric ingredients mainly includes inclusion, modification, etc., and the carriers mainly include succinic acid starch, hydroxypropyl starch, γ-cyclodextrin, β-cyclodextrin, microcrystalline cellulose, casein, Povidone, polyethylene glycol, etc., among which the most commonly used processing technology is cyclodextrin inclusion processing technology, but such products often only solve the problem of dispersion of curcuminoids in the carrier, but fail to solve the problem of curcumin Core issues and technical difficulties of low bioavailability of similar ingredients
Taking γ / β cyclodextrin inclusion technology as an example, its mechanism is to insert curcuminoid components into the bowl-shaped cavity formed by glucose units in the cyclodextrin structural molecule, which plays a role in dispersing curcuminoid components and encapsulating them. Although this preparation processing technology is simple, the result is only to solve the dispersion problem of curcuminoid components, and it is not ideal in improving the dissolution and bioavailability of curcuminoid components.

Method used

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  • High-bioavailability turmeric composition and preparation method thereof
  • High-bioavailability turmeric composition and preparation method thereof
  • High-bioavailability turmeric composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Take 1000kg of turmeric medicinal material and put it into a pulverizer for coarse crushing, put it in a multi-functional extraction tank, add 70% ethanol with 8 times the volume of the medicinal material, heat and reflux for extraction for 2.0 hours, filter the extract, and heat the dregs with 6 times the volume of 70% ethanol to reflux Extract for 1.0 hour, filter the extract, and set aside the filtrate; take the extract and concentrate it in a concentrator under reduced pressure. Heat preservation and crystallization to obtain effective ingredients of curcuminoids. Take 25 parts by weight of turmeric extract and dissolve it with an appropriate amount of ethanol solution, stir and dissolve evenly to obtain a solution of turmeric extract, and set aside; another 16 parts by weight of hydroxypropyl methylcellulose and 5 parts by weight of phospholipids are placed in a batching tank, and then added Water equivalent to 15 times the amount of hydroxypropyl methylcellulose a...

Embodiment 2

[0066] Take 20 parts by weight of turmeric extract and dissolve it with an appropriate amount of ethanol solution, stir and dissolve evenly to obtain a solution of turmeric extract, and set aside; another 15 parts by weight of hydroxypropyl methylcellulose and 5 parts by weight of phospholipids are placed in the batching tank, and then add Water equivalent to 15 times the amount of hydroxypropyl methylcellulose and stirred to dissolve evenly, then use a homogenizer, homogenization temperature: 50 ° C, pressure: 75MPa, to obtain a uniform and stable hydroxypropyl methylcellulose-phospholipid Sol, for standby; take the above turmeric extract solution and hydroxypropyl methylcellulose-phospholipid sol and mix them in the preparation tank, use a homogenizer for homogenization, homogenization temperature: 50°C, pressure: 35MPa; then add 59.5 Parts by weight of maltodextrin and 0.5 parts by weight of citric acid, mixed evenly; take the material liquid and dry it in a spray dryer, the...

Embodiment 3

[0068] Take 20 parts by weight of turmeric extract and dissolve it with an appropriate amount of ethanol solution, stir and dissolve evenly to obtain a solution of turmeric extract, and set aside; another 10 parts by weight of hydroxypropyl methylcellulose and 10 parts by weight of phospholipids are placed in a batching tank, and then add Water equivalent to 15 times the amount of hydroxypropyl methylcellulose and stirred to dissolve evenly, then use a homogenizer, homogenization temperature: 60 ° C, pressure: 65MPa, to obtain uniform and stable hydroxypropyl methylcellulose -- Phospholipid sol, spare; take the above turmeric extract solution and hydroxypropyl methylcellulose-phospholipid sol and mix them in the preparation tank, use a homogenizer for homogenization, homogenization temperature: 60°C, pressure: 25MPa; then add 58.5 parts by weight of maltodextrin and 1.5 parts by weight of citric acid are mixed evenly; the feed liquid is dried in a spray dryer, the inlet air tem...

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Abstract

The invention discloses a turmeric composition with high bioavailability and a preparation method thereof. The turmeric composition comprises a turmeric extract, hydroxypropyl methyl cellulose and phospholipid. According to the turmeric composition, phospholipid and hydroxypropyl methyl cellulose are used for forming high-dispersion amphoteric sol which has the lipophilic and hydrophilic characteristics, the turmeric extract is dispersed and then mixed with the amphoteric sol, drying is conducted, and the prepared turmeric composition has the advantages of being good in solubility and stability, high in bioavailability and the like.

Description

technical field [0001] The invention relates to the technical fields of food, health food and the like, in particular to a highly bioavailable turmeric composition and a preparation method thereof. Background technique [0002] Turmeric is a commonly used traditional Chinese medicine. It is derived from the dried rhizome of turmeric, a plant of the Zingiberaceae family. It has always been used to treat chest pain, chest pain, dysmenorrhea, amenorrhea, lumps, rheumatic shoulder and arm pain, tumbling swelling, etc. . Turmeric is not only used as a traditional medicinal material in China, but it is also eaten as a raw material for curry abroad, or used as a natural coloring agent, etc. In recent years, with the deepening of its research, more and more pharmacological activities of turmeric have been discovered, such as anti-tumor, anti-inflammatory, anti-diabetic, etc., which have good development prospects. [0003] The yellow component in turmeric is a mixture of various p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L29/20A23L29/262
CPCA23L33/105A23L29/20A23L29/262A23V2002/00A23V2200/30A23V2250/2112A23V2200/228A23V2250/51086A23V2250/5114A23V2250/032A23V2300/26A23V2300/14A23V2300/10
Inventor 何健刘美娟黄远英殷光玲张旭光
Owner BY HEALTH CO LTD
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