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Bio-based antibacterial composite bonding material and preparation method thereof

A kind of adhesive material, bio-based technology, applied in the field of medical materials, can solve the problems of loosening and sinking, inability to connect bone tissue, poor antibacterial performance, etc., and achieve the effect of reducing tissue thermal damage, increasing safety, and good combination

Inactive Publication Date: 2022-03-25
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional single polymethyl methacrylate adhesive material used as filling material and fixed prosthesis cannot be firmly connected with bone tissue due to poor biocompatibility, resulting in loosening and sinking, and the problem has become increasingly prominent; A large amount of heat is released during the process, and the local temperature may even be as high as 90°C, which can kill the surrounding living tissue cells; in addition, the traditional polymethyl methacrylate adhesive material does not have biological activity, and long-term implantation is easy to cause infection. Poor antibacterial performance

Method used

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  • Bio-based antibacterial composite bonding material and preparation method thereof
  • Bio-based antibacterial composite bonding material and preparation method thereof
  • Bio-based antibacterial composite bonding material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0038] Prepare the bio-based antibacterial composite adhesive material with a mass ratio of 1:1 of the solid phase part and the liquid phase part, and the specific steps are as follows:

[0039] S1: Mix 14.6g polymethyl methacrylate (73wt%), 1g contrast agent zirconium dioxide and 0.4g initiator benzoyl peroxide to obtain mixture A;

[0040] S2: Mix 4g polynitrofurfuryl methacrylate (20wt%) and mixture A to obtain the solid phase part;

[0041] S3: Mix 19.6 g of methyl methacrylate and 0.4 g of N,N-dimethyl-p-toluidine, filter and sterilize the resulting solution to obtain the liquid phase;

[0042] S4: Mix the solid phase part obtained in S2 and the liquid phase part obtained in S3 according to the mass ratio of the solid phase part and the liquid phase part at a ratio of 1:1. Curing for 10 minutes under the same conditions;

[0043] S5: The performance test of the bio-based antibacterial composite adhesive material obtained in S4 is performed, and the test results are list...

Embodiment 3

[0045] Prepare the bio-based antibacterial composite adhesive material with a mass ratio of solid phase and liquid phase of 1.5:1, the specific steps are as follows:

[0046] S1: Mix 17.1g polymethyl methacrylate (85.5wt%), 1.8g contrast agent barium sulfate and 0.1g initiator benzoyl peroxide to obtain mixture A;

[0047] S2: Mix 1.0g polynitrofurfuryl methacrylate (5wt%) and mixture A to obtain the solid phase part;

[0048] S3: Mix 14.88g of methyl methacrylate MMA and 0.12g of N,N-dimethyl-p-toluidine dmpt, filter and sterilize the resulting solution to obtain the liquid phase;

[0049] S4: Mix the solid phase part obtained in S2 and the liquid phase part obtained in S3 according to the mass ratio of the solid phase part and the liquid phase part at 1.5:1. After fully stirring, in an environment with a temperature of 21 ° C and a relative humidity of 60% Curing for 15 minutes under the same conditions;

[0050] S5: The performance test of the bio-based antibacterial comp...

Embodiment 4

[0052] The mass ratio of preparing solid phase part and liquid phase part is the bio-based antibacterial composite adhesive material of 2:1, and concrete steps are as follows:

[0053] S1: Mix 15.6g polymethyl methacrylate (78wt%), 0.7g contrast agent barium sulfate and 0.1g initiator benzoyl peroxide to obtain mixture A;

[0054] S2: Mix 3.6g polynitrofurfuryl methacrylate (18wt%) and mixture A to obtain the solid phase part;

[0055] S3: Mix 9.9 g of methyl methacrylate and 0.1 g of N,N-dimethyl-p-toluidine dmpt, filter and sterilize the resulting solution to obtain the liquid phase;

[0056] S4: Mix the solid phase part obtained in S2 and the liquid phase part obtained in S3 according to the mass ratio of the solid phase part and the liquid phase part at 2:1, and after fully stirring, in an environment with a temperature of 25 °C and a relative humidity of 50% Curing for 8 minutes under the same conditions;

[0057] S5: The performance test of the bio-based antibacterial ...

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Abstract

The invention discloses a bio-based antibacterial composite bonding material and a preparation method thereof. The bio-based antibacterial composite bonding material comprises a solid phase part, a solid phase part and a solid phase part, wherein the solid phase part comprises polymethyl methacrylate and polymethylacrylic acid nitro furfuryl alcohol ester; and the liquid phase part comprises methyl methacrylate and N, N-dimethyl p-toluidine. The preparation method of the bio-based antibacterial composite bonding material comprises the following steps: mixing the polymethyl methacrylate, the contrast agent and the initiator to obtain a mixture A; mixing the polymethylacrylic acid nitro furfuryl alcohol ester and the mixture A to obtain the solid phase part; mixing methyl methacrylate and N, N-dimethyl p-toluidine, and filtering and sterilizing the obtained solution to obtain the liquid phase part; and mixing the solid phase part and the liquid phase part, fully stirring, and curing. The bio-based antibacterial composite bonding material prepared by the invention is high in biological safety, excellent in antibacterial property and low in heat released by polymerization in a curing process.

Description

technical field [0001] The disclosure relates to the technical field of medical materials, in particular to a bio-based antibacterial composite adhesive material and a preparation method thereof. Background technique [0002] Polymethyl methacrylate adhesive material is the most commonly used orthopedic adhesive material in joint replacement and vertebral body reinforcement. In artificial total hip replacement, the main function of orthopedic adhesive material is to fill the femoral medullary cavity, fix the artificial joint prosthesis and disperse the stress. In percutaneous vertebroplasty and percutaneous balloon kyphoplasty, orthopedic adhesive material is injected into the vertebral body in patients with osteoporotic vertebral compression fractures to provide rapid pain relief and Increase the strength and stability of the vertebral body, prevent collapse and restore the height of the vertebral body. [0003] The traditional single polymethyl methacrylate adhesive mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00A61L24/02
CPCA61L24/06A61L24/0015A61L24/001A61L24/02A61L2300/216A61L2300/404C08L33/12C08L33/14
Inventor 储建军傅尧李闯郭靖
Owner UNIV OF SCI & TECH OF CHINA
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