Preparation method of halogenated acid compound

A compound and acid technology, which is applied in the field of preparation of halogenated acid compounds, can solve the problems of poor safety and controllability, severe reaction triggering, increased pressure on wastewater treatment, etc., and achieves the effects of low toxicity, high yield, toxicity and environmental protection
CN114230451APending Publication Date: 2022-03-25上海药坦药物研究开发有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
上海药坦药物研究开发有限公司
Publication Date
2022-03-25

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Abstract

The invention discloses a preparation method of a halogenated acid compound. Specifically, the invention provides a preparation method of a halogenated acid compound as shown in a formula I. A halogenated alcohol compound as shown in a formula II is taken as a raw material and reacts with TEMPO, sodium hypochlorite and sodium chlorite, the reaction pH is regulated by carbon dioxide which is low in cost and easy to obtain, and finally the halogenated acid compound is prepared. The preparation method is high in yield, relatively low in toxicity, environment-friendly and suitable for industrial production.
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Description

technical field

[0001] The invention relates to a preparation method of halogenated acid compounds. Background technique

[0002] As an excellent pharmaceutical and pesticide intermediate, 8-bromooctanoic acid has the following structure:

[0003]

[0004] Regarding the synthesis of 8-bromooctanoic acid, there are relatively few methods, and the more conventional ones are as shown in patent CN113087623: 1,6-dibromohexane is used as the main raw material to carry out substitution reaction with diethyl malonate, and then hydrolyzed by ester group And decarboxylation to obtain 8-bromooctanoic acid. The reaction time of this route is long, the conversion rate of the first step is low, the temperature of the decarboxylation reaction is high, and there are many by-products. At the same time, in order to increase the selectivity of the first step of substitution, the raw material 1,6-dibromohexane is greatly excessive.

[0005] Route 1:

[0006]

[0007] Refer to J.Org.Che...

Claims

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