Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese medicine monomer isoorientin for treating diabetic nephropathy

A technology of diabetic nephropathy and isorientin, which is applied in the field of traditional Chinese medicine monomer isorientin, can solve the problems of no research on the effect of diabetic nephropathy, lack of therapeutic drugs, and no public literature reports, etc., achieving no toxic side effects, wide sources and easy access The effect of gaining and low cost

Inactive Publication Date: 2022-03-25
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a lack of effective therapeutic drugs to protect podocytes
[0004] At present, traditional Chinese medicine has been widely used in the prevention and treatment of diabetes and its complications. Fenugreek has been considered as an effective drug for the treatment of DN, but the effect of fenugreek monomers on diabetic nephropathy has not been studied, nor is there any public literature to report

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine monomer isoorientin for treating diabetic nephropathy
  • Traditional Chinese medicine monomer isoorientin for treating diabetic nephropathy
  • Traditional Chinese medicine monomer isoorientin for treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] This example first confirmed that high glucose causes autophagy exhaustion, and then leads to podocyte apoptosis and mitochondrial damage, but isorientin can change this result, and then the effect of autophagy or mitophagy on MPC-5 mouse podocytes Experimental research on the role of DN has confirmed that it is a protective factor for podocytes of DN. The specific experimental process is as follows:

[0022] (1) Animal experiments:

[0023] (1) Construct an animal model: select male C57BL / 6J mice aged 5 to 6 weeks, keep the room temperature at 25 ± 2°C, and keep the humidity at (55 ± 5)%. 12h day and night cycle; Before the experiment, the mice had a normal diet and drinking water, and adapted to the environment for 2 weeks, randomly selected 8 of the 50 mice as the normal control group, and the remaining 42 mice were fed with a 60% high-fat diet After feeding the mice for 4 weeks, the mice were injected with small doses (40mg / kg) of streptozotocin (STZ) continuously ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine monomer isoorientin for treating diabetic nephropathy, which is a flavonoid compound containing a luteolin structure, exists in medicinal or edible parts of plants such as sow thistle, buckwheat, passion flower and common fenugreek seed, has a molecular formula of C21H20O11, and can be used for treating diabetic nephropathy. The traditional Chinese medicine monomer isoorientin is used for treating diabetic nephropathy, the curative effect is good, no toxic or side effect exists, the isoorientin is wide in source and easy to obtain, and the cost is low.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine monomer isorientin for treating diabetic nephropathy. Background technique: [0002] Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes and one of the most common causes of end-stage renal disease. Although the pathogenesis of DN is caused by many factors, more and more diabetic patients and animal models have shown that the abnormal structure and function of podocytes in the process of diabetic nephropathy plays an important role in the occurrence and development of renal injury in diabetic nephropathy. role. Podocytes are highly differentiated and terminally differentiated epithelial cells that play an important role in the transport of the glomerular basement membrane (GBM), the maintenance of the glomerular filtration barrier, and the regulation of glomerular filtration. Due to the limited...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04A61P13/12A61P3/10
CPCC07D407/04A61P13/12A61P3/10Y02A50/30
Inventor 孔姿莉迟静薇王颜刚
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com