Nano-emulsion with anti-oxidation effect and preparation method thereof

A nano-emulsion, anti-oxidation technology, applied in cosmetic preparations, preparations for skin care, cosmetics, etc., can solve the preparation and application limitations of multi-component antioxidants, differences in stability or solubility, difficult skin deep anti-oxidation, etc. problems, to achieve the effect of reducing stability problems, improving stability, and improving antioxidant properties

Active Publication Date: 2022-04-05
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although studies have shown that the antioxidant activity of monomers is often not as high as that of multi-component antioxidants, due to the differences in the stability or solubility of existing antioxidants, it is not suitable for the preparation and application of multi-component antioxidants. somewhat limited
On the other hand, most of the existing antioxidants only stay on the surface of the skin, and it is difficult to enter the deep layer of the skin to exert the antioxidant effect
As a result, most of these antioxidants will be wasted due to the lack of a good skin deep delivery system, and the desired effect cannot be achieved
[0004] Therefore, the existing antioxidant composition has the problems of poor antioxidant performance, low stability and poor transdermal absorption effect

Method used

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  • Nano-emulsion with anti-oxidation effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1. A nanoemulsion with anti-oxidation effect comprises the following components in parts by weight: 0.5-5 parts of bakuchiol, 0.1-5 parts of acetylzingerone and 0.01-2 parts of pyrroloquinoline quinone.

[0023] A kind of preparation method of described nanoemulsion with antioxidant effect, comprises the following steps:

[0024] ① Mix 0.5-5 parts of bakuchiol, 0.1-5 parts of acetyl zingerone, 2 parts of polyglycerol-2 oleate and 15 parts of caprylic / capric triglyceride and heat to 50 ~85°C, then stirred for 30 minutes to obtain oil phase A;

[0025] ② Mix 0.01-2 parts of pyrroloquinoline quinone, 2 parts of polyglycerol-10 myristate, 33 parts of glycerin and 46.4 parts of water in proportion, heat to 50-85°C and stir for 20 minutes to obtain B water box;

[0026] ③Add oil phase A into water phase B and stir, then high-speed shear at 15000r / min for 5min to obtain emulsion C;

[0027] ④ Use a high-pressure homogenizer to homogenize the C emulsion for 8 times ...

Embodiment 2

[0030] Example 2. A nanoemulsion with antioxidant effect comprises the following components in parts by weight: 1 part of bakuchiol, 0.5 part of acetylzingerone and 0.1 part of pyrroloquinoline quinone disodium salt.

[0031] A kind of preparation method of described nanoemulsion with antioxidant effect, comprises the following steps:

[0032] ① Mix 1 part of bakuchiol, 0.5 parts of acetyl zingerone, 2 parts of polyglycerol-2 oleate and 15 parts of caprylic / capric triglyceride in proportion, heat to 75°C, and stir 30min, get A oily phase;

[0033] ② Mix 0.1 part of pyrroloquinoline quinone disodium salt, 2 parts of polyglycerol-10 myristate, 33 parts of glycerin and 46.4 parts of water in proportion, heat to 75°C and stir for 20 minutes to obtain water B Mutually;

[0034] ③Add oil phase A into water phase B and stir, then high-speed shear at 15000r / min for 5min to obtain emulsion C;

[0035] ④ Use a high-pressure homogenizer to homogenize the C emulsion for 8 times under ...

experiment example 1

[0037] Experimental Example 1: Take the nanoemulsion prepared in Example 2 as a sample, draw 10 μL of the sample into a centrifuge tube, add an appropriate amount of deionized water to dilute the emulsion, and then use a nanoparticle size analyzer to measure the particle size, and each sample is parallel Measured 3 times, and the measured values ​​were averaged.

[0038] The test results are: the average particle diameter of the sample is 65.6nm, and the PDI is 0.21. According to the test results, the nanoemulsion prepared by the present application can have excellent uniformity.

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Abstract

The invention discloses a nano-emulsion with an anti-oxidation effect. The nano-emulsion is prepared from the following components in parts by weight: 0.5 to 5 parts of bakuchiol, 0.1 to 5 parts of acetyl zingerone and 0.01 to 2 parts of pyrroloquinoline quinone or salt thereof. Meanwhile, the invention provides a preparation method of the nano-emulsion, which comprises the following steps: firstly, mixing the bakuchiol, the acetyl zingerone, the polyglycerol-2 oleate and the caprylic/capric triglyceride in proportion, heating to 50-85 DEG C, and stirring for 30 minutes to obtain an oil phase; then mixing pyrroloquinoline quinone or salts thereof, polyglycerol-10 myristate, glycerol and water in proportion, heating to 50-85 DEG C, and stirring for 20 minutes to obtain a water phase; adding the oil phase into the water phase, stirring, and shearing at a high speed for 5 minutes to obtain an emulsion; and finally, homogenizing and circulating the emulsion for 8 times by using a high-pressure homogenizer to obtain the finished product emulsion. The composite material has the characteristics of good oxidation resistance and high stability.

Description

technical field [0001] The invention relates to an antioxidant composition, in particular to a nanoemulsion with antioxidant effect and a preparation method thereof. Background technique [0002] Reactive oxygen species, commonly referred to as free radicals or oxidants, include ROS (oxygen-containing oxidizing chemical species), RNS (nitrogen-containing oxidizing chemical species), reactive sulfur species, and activated carbon species, where ROS are produced by mitochondrial metabolism by-product. UVA, UVB, visible light, infrared light, pollutants and psychological stress can externally induce reactive oxygen species in the skin. Humans have an innate antioxidant defense system that includes different antioxidant enzymes as well as non-enzymatic antioxidants such as glutathione, vitamin C and vitamin E. However, if the external stimulus is excessive, the body's antioxidant system will fail. Too much active substances, including active oxygen and nitrogen, can exacerbate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/06A61K8/34A61K8/35A61Q19/08
CPCY02A50/30
Inventor 张大勇毕永贤杜雨涵李昊周浩淼胡雪情孔德承
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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