Novel photosensitizer as well as preparation method and application thereof
A photosensitizer, a new type of technology, applied in the field of photosensitizers, can solve problems such as high oxygen dependence, and achieve the effect of outstanding universality and high-efficiency treatment
Pending Publication Date: 2022-04-12
SHANDONG UNIV
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The invention discloses a novel photosensitizer and a preparation method and application thereof, and the preparation method comprises the following steps: adding thionyl chloride into a methanol suspension of D-biotin, stirring overnight at room temperature until a reaction solution is clear and transparent, and carrying out reduced pressure distillation to obtain a white solid; dispersing into methanol, slowly dropwise adding hydrazine hydrate while stirring, heating, and reacting for 10-18 hours; cooling to room temperature, carrying out reduced pressure distillation, pouring methanol, carrying out suction filtration, and washing with methanol for several times to obtain a white powdery compound I; the preparation method comprises the following steps: dissolving a photosensitizer compound II with carboxyl at a terminal in anhydrous DMF in a nitrogen atmosphere, adding EDCI, HOBt and DIEA at 0 DEG C, reacting for 2 hours, adding a compound I, and stirring at room temperature for 24 hours; and performing reduced pressure distillation and purification to obtain a compound III. The novel photosensitizer prepared by the invention can solve the problem of high dependence on oxygen in photodynamic therapy, and has a good treatment effect in both normal oxygen and hypoxic states.
Application Domain
Technology Topic
PhotosensBiotin +10
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