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Modified hydrogel as well as preparation method and application thereof

A technology for modifying water and gel, applied in medical science, bandages, etc., can solve problems such as limited application, and achieve the effects of excellent antibacterial properties, excellent antibacterial effect, and simple preparation method

Pending Publication Date: 2022-04-12
THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatins can form hydrogels through physical crosslinking of thermal gels, but their gelation temperatures are often above the physiological range, limiting their applications in mammalian cells and in vivo

Method used

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  • Modified hydrogel as well as preparation method and application thereof
  • Modified hydrogel as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0041] The preparation method of described modified nano cerium oxide colloid comprises the steps:

[0042] Mixing the raw materials used to prepare the modified nano-cerium oxide colloid in water, and performing ball milling;

[0043] The raw materials include nano silver and nano cerium oxide.

[0044] The specific cross-linking agent can cross-link and polymerize gelatin into a hydrogel with a network structure, reduce the gel temperature and viscosity of the modified hydrogel, and form a gel in the range of 32°C ± 5°C, and It can swell in water at room temperature, and ball milling can collide with active sites on the surface of nano-cerium oxide. Nano-silver is grafted on nano-cerium oxide through active sites, endowing the modified nano-cerium oxide colloid with excellent antibacterial properties, improving The permanent nano-cerium oxide is filled in the hydrogel network, which endows the modified hydrogel with excellent antibacterial properties and further reduces the...

Embodiment 1

[0071] This embodiment provides a modified hydrogel and its preparation method and application. details as follows:

[0072] (1) Weigh 1g of PVP powder and dissolve it in 19g of deionized water. After the PVP is completely dissolved, slowly add 20g of silver nitrate solution (the concentration of silver nitrate is 0.1mol / L), and stir at room temperature for 4 hours to obtain nano-silver sol.

[0073] (2) Weigh 2.5 mg of commercially available nano-cerium oxide particles with a particle size of 50 nm and 0.5 mg of nano-silver sol in 100 mL of deionized aqueous solution, place them in a ball mill at 300 rpm, and mill at 37 ° C for 3 hours to obtain cerium oxide / silver The modified nano cerium oxide colloidal solution with a concentration of 25ppm.

[0074] (3) Weigh 10g of gelatin particles (Mw: 10000g / mol) and dissolve in 20g of the above-mentioned 25ppm modified nano-cerium oxide solution, heat and stir in a water bath at 80°C until the gelatin particles are completely dissol...

Embodiment 2

[0077] This embodiment provides a modified hydrogel and its preparation method and application. details as follows:

[0078] (1) Weigh 1g of PVP powder and dissolve it in 19g of deionized water. After the PVP is completely dissolved, slowly add 20g of silver nitrate solution (the concentration of silver nitrate is 0.1mol / L), and stir at room temperature for 4 hours to obtain nano-silver sol.

[0079] (2) Weigh 5 mg of commercially available nano-cerium oxide particles with a particle size of 50 nm and 0.5 mg of nano-silver sol in 100 mL of deionized aqueous solution, place them in a ball mill at 300 rpm, and mill at 37 ° C for 3 hours to obtain the concentration of cerium oxide / silver It is the modified nano cerium oxide colloidal solution of 50ppm.

[0080] (3) Weigh 10g of gelatin particles (Mw: 10000g / mol) and dissolve in 20g of the above-mentioned 50ppm modified nano-cerium oxide solution, heat and stir in a water bath at 80°C until the gelatin particles are completely di...

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Abstract

The invention relates to modified hydrogel as well as a preparation method and application thereof. The modified hydrogel is prepared from the following raw materials: water, gelatin, a cross-linking agent and modified nano cerium oxide colloid, the cross-linking agent is a mixture of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, and the mass ratio of the 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to the N-hydroxysuccinimide is (0.8-1.2): 1; the preparation method of the modified nano cerium oxide colloid comprises the following steps: mixing raw materials for preparing the modified nano cerium oxide colloid in water, and carrying out ball milling treatment; the raw materials comprise nano silver and nano cerium oxide. Through the synergistic effect of the raw materials, the modified hydrogel provided by the invention has an excellent antibacterial effect, also has the advantages of low gel temperature, low viscosity, skin friendliness, conductivity and moisture absorption, has the potential of replacing classical materials, and can be used for antibacterial dressings.

Description

technical field [0001] The invention relates to the field of hydrogel technology, in particular to a modified hydrogel and its preparation method and application. Background technique [0002] Wounds are easily affected by inflammation caused by bacterial infection, which affects the healing speed. Traditional dressings do not have antibacterial function. Therefore, the industry urgently needs a dressing that can not only promote wound healing, but also prevent wound infection. [0003] Hydrogels have been applied in various biomaterials, such as 3D cell culture, tissue engineering, and drug delivery, etc. Hydrogel can promote rapid epithelialization and wound healing, and has partially replaced traditional gauze and has become an important material for clinical wound dressings. The hydrogel can keep the callus and epithelial cells in a moist environment, accelerate the synthesis of collagen and the proliferation of fibroblasts. However, due to the insufficient antibacteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L89/00C08K3/22C08K3/08C08K9/02C08K5/29C08K5/3415A61L26/00
Inventor 郑文富杨姗姗赵宇亮
Owner THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION