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Screening process of active ingredients of natural medicine

A technology of active ingredients and natural medicines, applied in the field of medicine, can solve the problems of low extraction rate of artemisinin, inconspicuous crushing effect, cumbersome artemisinin process, etc., and achieve shortened extraction time, high practicability, and convenient cleaning Effect

Inactive Publication Date: 2022-04-22
陈传妹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing process for extracting artemisinin from Artemisia annua plants is cumbersome, time-consuming, and costly. In the process of extracting artemisinin, a crushing device is often used. The crushing efficiency of the existing crushing device is low, and the crushing effect is not good. Obviously, resulting in low extraction rate of artemisinin

Method used

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  • Screening process of active ingredients of natural medicine
  • Screening process of active ingredients of natural medicine
  • Screening process of active ingredients of natural medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0045] A screening process for active ingredients of natural medicines, comprising the steps of:

[0046] Step 1, weighing the following raw materials in parts by weight: 50 parts of Artemisia annua raw materials, 20 parts of petroleum ether and 30 parts of 90% ethanol;

[0047] Step 2, raw material drying treatment, putting the Artemisia annua raw material into microwave drying equipment and drying at a temperature of 55°C for 40 minutes;

[0048] Step 3, add the dried Artemisia annua raw materials into a crushing device for crushing, pass through a 120-mesh sieve to obtain Artemisia annua powder, put it into an ultrasonic device, and perform ultrasonic extraction to obtain an extract 1, the ultrasonic frequency is 30KHz, and the temperature is 50°C, time 1;

[0049] Step 4: Concentrate the extract 1 under reduced pressure to a relative density of 1.0 to obtain a crude artemisinin extract paste, then add petroleum ether and stir evenly for 1 extraction, and combine the extra...

Embodiment 2

[0053] A screening process for active ingredients of natural medicines, comprising the steps of:

[0054] Step 1, weighing the following raw materials in parts by weight: 55 parts of Artemisia annua raw materials, 25 parts of petroleum ether and 35 parts of 90% ethanol;

[0055] Step 2, raw material drying treatment, put the Artemisia annua raw material into microwave drying equipment and carry out drying treatment at a temperature of 65°C for 45 minutes;

[0056] Step 3, add the dried Artemisia annua raw materials into a crushing device for crushing, pass through a 140-mesh sieve to obtain Artemisia annua powder, put it into an ultrasonic device, and perform ultrasonic extraction to obtain an extract 1, the ultrasonic frequency is 35KHz, and the temperature is 55℃, the time is 1.5h;

[0057] Step 4: Concentrate the extract 1 under reduced pressure to a relative density of 1.1 to obtain a crude artemisinin extract paste, then add petroleum ether and stir evenly to perform 2 e...

Embodiment 3

[0061] A screening process for active ingredients of natural medicines, comprising the steps of:

[0062] Step 1, weighing the following raw materials in parts by weight: 60 parts of Artemisia annua raw materials, 30 parts of petroleum ether and 40 parts of 90% ethanol;

[0063] Step 2, raw material drying treatment, put the Artemisia annua raw material into microwave drying equipment and carry out drying treatment at a temperature of 75°C for 50 minutes;

[0064] Step 3, add the dried Artemisia annua raw materials into a crushing device for crushing, pass through a 160-mesh sieve to obtain Artemisia annua powder, put it into an ultrasonic device, and perform ultrasonic extraction to obtain an extract 1, the ultrasonic frequency is 40KHz, and the temperature is 60℃, the time is 2h;

[0065] Step 4: Concentrate the extract 1 under reduced pressure to a relative density of 1.2 to obtain a crude artemisinin extract paste, then add petroleum ether and stir evenly for 3 extraction...

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Abstract

The invention discloses a process for screening active ingredients of a natural medicine. The process comprises the following steps: step 1, weighing raw materials; step 2, drying the raw material: putting the artemisia apiacea raw material into microwave drying equipment for drying; step 3, adding the dried artemisia apiacea raw material into a crushing device for crushing, sieving with a 120-160-mesh sieve to obtain artemisia apiacea powder, putting the artemisia apiacea powder into ultrasonic equipment, and performing ultrasonic extraction to obtain an extracting solution I; step 4, concentrating the extracting solution I under reduced pressure until the relative density is 1.0-1.2 to obtain crude artemisinin extracting paste, then adding petroleum ether, uniformly stirring, extracting for 1-3 times, and combining extracting solutions to obtain an extracting solution II; and step five, placing the second extracting solution in 90% ethanol for standing, taking the supernate for precise filtration, placing the filtrate in a concentration tank for concentration, placing the concentrated solution in a crystallizing tank, after crystallization is completed, carrying out suction filtration on the mother solution to obtain crystals, and carrying out vacuum drying treatment on the crystals to obtain a refined artemisinin product.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a screening process for active ingredients of natural medicines. Background technique [0002] Artemisinin is the drug with the best effect in the treatment of malaria drug resistance, and artemisinin-based combination therapy is also the most effective and important means of treating malaria at present. However, with the deepening of research in recent years, more and more other effects of artemisinin have been discovered and applied research, such as anti-tumor, treatment of pulmonary hypertension, anti-diabetes, embryotoxicity, anti-fungal, immune regulation, anti-virus, anti-inflammatory , anti-pulmonary fibrosis, antibacterial, cardiovascular effects and other pharmacological effects. [0003] At present, the technology of extracting artemisinin from Artemisia annua in China is mainly the traditional organic solvent extraction and separation method, that is, using organic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B02C21/00B02C4/02B01D11/02
CPCB02C21/00B02C4/02B01D11/0265
Inventor 不公告发明人
Owner 陈传妹