Nano bioactive glass hydrogel composite material and preparation method thereof

Abstract

The invention discloses a nano bioactive glass hydrogel composite material and a preparation method thereof. The composite material takes agarose-xanthan gum hydrogel as a carrier, and a nano bioactive glass material is loaded in a three-dimensional network structure of the agarose-xanthan gum hydrogel. The preparation method of the composite material comprises the following three steps: preparation of the nano bioactive glass material, preparation of agarose-xanthan gum hydrogel and preparation of the bioactive glass hydrogel composite material. The nano bioactive glass is loaded by the agarose-xanthan gum hydrogel, and the prepared composite material has improved viscosity and functions, can be continuously retained on the tooth surface to provide stable mineral ion release, and does not change the activity of the nano bioactive glass.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a composite material of agarose-xanthan gum hydrogel loaded with nano bioactive glass and a preparation method thereof. Background technique [0002] Dentin hypersensitivity (DH), a common clinical dental disease in adults, is a serious global oral health problem. The incidence of DH remains high, especially among young people, and in Europe, 42% of people aged 18-35 suffer from DH. In patients with periodontal disease, the prevalence is even higher, ranging from 68-98%. The incidence of DH is high, and the therapeutic effect, especially the long-term curative effect, is not good, which is a rather difficult problem in clinical practice. [0003] Considerable research has been devoted to understanding the causes of DH, the pathogenesis, and developing effective treatments for DH. However, there are currently no commercially available materials to treat DH by permanently bl...

AI Technical Summary

Problems solved by technology

[0006] But the long reaction time and low blocking percentage limit its practicality, and the rod-shaped physical blocking makes the sealing effect and durability unsatisfactory.

Moreover, bioactive glass is unstable in body fluids and is easily hydrolyzed

At the same time, the inherent dynamic environment in the oral cavity makes these powders easily removed before the bioactive glass is fully dissolved and nucleated, and the duration of contact with the tooth is short, which limits its application in dentin remineralization.

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