Light-cured oral gel as well as preparation method and application thereof
A light-curing, oral technology, used in the field of biomedicine, can solve the problems of short retention time of oral care solution, cure the symptoms but not the root cause, and side effects of analgesics, achieve efficient isolation and treatment, ensure biocompatibility, and not easy to fall off. Effect
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Embodiment 1
[0033] Dissolve 2 g of GelMA (methacrylic anhydride gelatin) into 100 ml of PBS solution, add 0.3 g of N-hydroxysuccinimide (NHS), 0.5 g of 1-(3-dimethylaminopropyl base)-3-ethylcarbodiimide (EDC), then adjust the pH of the solution to 5, and pour the solution into a double-necked flask after 30 minutes of reaction, vacuumize and pass nitrogen protection under the condition of 37 ° C water bath, and then Add 2g of dopamine (adhesive agent) into the double-necked flask, and react for 10h in a nitrogen atmosphere. After the reaction, it was purified by dialysis for one week under acidic conditions and lyophilized. The material can be stored in a dry -20°C environment for a long time.
[0034] Add the oral gel material prepared above into PBS to make a 10 mg / ml (w / v) solution, add 0.5% (w / v) phenyl-2,4,6-trimethylbenzoylphosphine Lithium acid photoinitiator, and add 5% (w / v) of gentamicin, put into the watering can after mixing, spray on dry and wet objects, and irradiate with ...
Embodiment 2
[0037] Dissolve 2g of methacrylic acylated protein into 100ml of PBS solution, add 0.3g of N-hydroxysuccinimide (NHS) and 0.5g of 1-(3-dimethylaminopropyl) in a water bath at 37°C -3-Ethylcarbodiimide (EDC), then adjust the pH of the solution to 5, and pour the solution into a double-necked flask after 30 minutes of reaction, vacuumize under the condition of a water bath at 37°C and pass in nitrogen protection, and then to the double-necked flask Add 2g of dopamine (adhesive agent) into the neck flask, and react for 10h in a nitrogen atmosphere. After the reaction, it was purified by dialysis for one week under acidic conditions and lyophilized. The material can be stored in a dry -20°C environment for a long time.
[0038] Add the oral gel material prepared above into PBS to make a 10 mg / ml (w / v) solution, add 0.5% (w / v) phenyl-2,4,6-trimethylbenzoylphosphine Lithium acid photoinitiator, and add 5% (w / v) of gentamicin, put into the watering can after mixing, spray on dry an...
Embodiment 3
[0040] Dissolve 2 g of methacrylic acid acylated hyaluronic acid into 100 ml of PBS solution, add 0.3 g of N-hydroxysuccinimide (NHS), 0.5 g of 1-(3-dimethylaminopropyl )-3-ethylcarbodiimide (EDC), then adjust the pH of the solution to 5, and pour the solution into a double-necked flask after 30 minutes of reaction, vacuumize and pass into nitrogen protection under the condition of 37 ° C water bath, and then Add 2g of dopamine (adhesive agent) into the double-necked flask, and react for 10h in a nitrogen atmosphere. After the reaction, it was purified by dialysis for one week under acidic conditions and lyophilized. The material can be stored in a dry -20°C environment for a long time.
[0041] Add the oral gel material prepared above into PBS to make a 10 mg / ml (w / v) solution, add 0.5% (w / v) phenyl-2,4,6-trimethylbenzoylphosphine Lithium acid photoinitiator, and add 5% (w / v) of gentamicin, put into the watering can after mixing, spray on dry and wet objects, and irradiate ...
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