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Hydrogel embedded with chloroquine drugs as well as preparation method and application of hydrogel

A hydrogel and chloroquine technology, applied in the field of hydrogel embedded with chloroquine drugs and its preparation, can solve the problems of low efficiency, serious time-consuming, complicated loading process, etc., and achieve high yield and rapid response , reproducible effect

Pending Publication Date: 2022-05-13
杭州食疗晶元生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to overcome the defects of the hydrogel preparation process in the prior art and its complex, time-consuming and low-efficiency loading process for medicinal components, and provides a hydrogel embedded with chloroquine drugs and its Preparation method and application to overcome above-mentioned defects

Method used

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  • Hydrogel embedded with chloroquine drugs as well as preparation method and application of hydrogel
  • Hydrogel embedded with chloroquine drugs as well as preparation method and application of hydrogel
  • Hydrogel embedded with chloroquine drugs as well as preparation method and application of hydrogel

Examples

Experimental program
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Effect test

Embodiment 1~3

[0045] Prepare a pure milk sample with a hydroxychloroquine concentration of 6 / 8 / 10 (mg / mL) (the dry matter in the milk is about 30 mg / mL, the same below), homogenize at a homogenization speed of 5000 r / min, and control the constant temperature Treat at 40°C for 10 minutes, cool to room temperature and then centrifuge, centrifugation conditions: 500 r / min, 10min. After the centrifugation was completed, the sample supernatant was carefully removed, and the precipitate was placed in a -80°C refrigerator and monitored in real time with a thermometer until the temperature dropped rapidly to 4°C and kept at a constant temperature for 30 minutes to obtain the prepared hydrogel.

Embodiment 4

[0052] Take 100 mL of pure milk, add 1g of hydroxychloroquine, put it in a 250mL beaker for homogenization, respectively carry out homogenization at a homogenization speed of 5000r / min, treat at a controlled constant temperature of 40°C for 10 minutes, cool to room temperature and use Nano- ZS dynamic light scattering instrument was used for characterization and then centrifuged. Centrifugal conditions: 500 r / min, 10min. After the centrifugation was completed, the supernatant of the sample was carefully removed, and the precipitate was placed in a -80°C refrigerator and monitored in real time with a thermometer until the temperature dropped rapidly to 4°C and kept at a constant temperature for 30 minutes to obtain the required milk hydrogel loaded with hydroxychloroquine.

Embodiment 5~7

[0059] Draw 100 mL of pure milk, add 1 g of hydroxychloroquine and place it in a 250 mL beaker for homogenization. Select the optimal rotation speed of 5000r / min, and then conduct centrifugation after treatment in a water bath at 40°C for 10 minutes. Centrifugation conditions: 500g, 10min. After the centrifugation was completed, the sample supernatant was carefully sucked off, and the watery precipitate was quickly placed in a -20°C refrigerator and monitored in real time with a thermometer until the temperature dropped rapidly to 4, 10, and 25°C, then taken out, and then characterized by a scanning electron microscope after standing for 30 minutes. Scanning electron microscope results such as Figure 4 . Comparing the conditions of different rapid drop temperatures, it can be found that different rapid drop temperatures play a key role in the formation of hydrogels. A stable hydrogel structure cannot be formed at a temperature of 25°C. A basic hydrogel network structure was...

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Abstract

The invention relates to a preparation method of hydrogel, in particular to hydrogel embedded with chloroquine medicine as well as a preparation method and application thereof, the preparation method comprises the following steps: (1) adding chloroquine medicine into a liquid dairy product, uniformly mixing, and performing phase separation on the liquid dairy product to obtain a mixed solution; (2) shearing and homogenizing the mixed solution to obtain a homogenized solution; (3) centrifuging the homogenized liquid, removing supernatant and unreacted chloroquine drugs in the supernatant after centrifugation is completed, and taking precipitate for later use; and (4) reducing the precipitation temperature to form gel, so as to obtain the hydrogel embedded with the chloroquine medicine. The hydroxychloroquine-dairy product flexible hydrogel prepared by a two-step method of demulsification reassembly and temperature control gel forming has the advantages of strong reproducibility, simple operation, fast reaction and high yield. The prepared hydrogel is expected to play a good role in immunoregulation, malaria disease resistance, digestive disease resistance and virus resistance.

Description

technical field [0001] The invention relates to a preparation method of a hydrogel, in particular to a hydrogel embedded with chloroquine drugs, a preparation method and application thereof. Background technique [0002] Chloroquine and hydroxychloroquine are a class of classic anti-malarial drugs with strong water solubility. They mainly act on the red inner stage of Plasmodium and can effectively control the onset of malaria symptoms. [0003] Hydrogel is a material with a three-dimensional polymer network structure composed of hydrophilic polymer chains, which is between viscous liquid and elastic solid, and has strong water holding capacity and swelling coefficient. Due to the good biocompatibility of hydrogel and the harmlessness of its degradation products when in contact with blood, body fluids and human tissues, this material is widely used in tissue engineering, drug delivery and embedding of effective substances. This kind of entrapment is expected to improve the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4706A61K47/46A61P1/00A61P31/12A61P33/06A61P37/02
CPCA61K9/06A61K31/4706A61K47/46A61P37/02A61P1/00A61P31/12A61P33/06Y02A50/30
Inventor 徐天豪余兆硕柯李晶罗思浩周建武饶平凡
Owner 杭州食疗晶元生物科技有限公司
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