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A polydopamine-coated sustained-release MNO 2 Nanoparticle drug delivery system

A nano-microsphere and drug-carrying system technology, applied in the field of biomedicine, can solve the problems of high toxicity and side effects, low selection specificity, and application limitations, and achieve the effects of high targeting, good biocompatibility, and convenient operation

Active Publication Date: 2022-07-26
ZHEJIANG CANCER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Doxorubicin (DOX) is a small-molecule anti-cancer drug that has significant effects on many types of tumors in the human body, but the selection specificity is low, and the toxicity and side effects are relatively large, so the application is greatly limited

Method used

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  • A polydopamine-coated sustained-release MNO <sub>2</sub> Nanoparticle drug delivery system
  • A polydopamine-coated sustained-release MNO <sub>2</sub> Nanoparticle drug delivery system
  • A polydopamine-coated sustained-release MNO <sub>2</sub> Nanoparticle drug delivery system

Examples

Experimental program
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Effect test

preparation example Construction

[0075] Provide the aforementioned sustained-release MnO 2 The preparation method of the new drug-carrying system of nano-microspheres includes:

[0076] Step 1: The glucose solution with a concentration of 0.01-0.5M is transferred to a tetrafluoroethylene autoclave, hydrothermally reacted at a temperature of 150-300 ° C for at least 12 hours to obtain a brown precipitate, washed several times with deionized water and absolute ethanol, Dry in a blast oven at 60-90 °C to obtain carbon nanospheres;

[0077] Step 2: Nano carbon balls are ultrasonically dispersed in deionized water to obtain a nano carbon ball water dispersion, adjusted to 1-5 with concentrated HCl, according to nano carbon balls and KMnO 4 Powder weight ratio of 1:2-4 is added to KMnO 4 Powder, continue to ultrasonically disperse for at least 10min, react at 80-150℃ for 30min-12h, and generate MnO in situ 2 , washed with deionized water and absolute ethanol, dried, and sintered at 200-500 °C for not less than 2...

Embodiment 1

[0089] Provide a slow-release MnO 2 A new drug-loading system for nano-microspheres, specifically pH-controlled release and folic acid-targeted drug-loading MnO 2 Nanocomposite hollow sphere, its preparation process is as follows figure 1 As shown, the preparation method includes the following steps.

[0090](1) Preparation of carbon nanospheres: magnetically stir 0.1M 30mL glucose solution uniformly and transfer it to a 50mL tetrafluoroethylene autoclave for hydrothermal reaction at 180°C for 15h; deionized water is used for the obtained brown precipitate and anhydrous ethanol were washed 3 times respectively, placed in an 80°C blast oven and dried to constant weight to obtain carbon nanospheres.

[0091] (2) Preparation of MnO 2 Nano hollow sphere: Ultrasonic 0.042g nano carbon sphere (35KHz, 0.4W / cm 2 ) was dispersed in 20 mL of deionized water, and the pH was adjusted to 2.5 with concentrated HCl; then 0.111 g of KMnO was added to the suspension 4 Powder, continue to ...

Embodiment 2

[0096] Characterization of nanomaterials, the potential of nanomedicines at different pH values ​​(5.0 and 7.4) was tested using a Malvern nanoparticle size analyzer. The result is as Image 6 As shown, at pH=7.4 (simulating the blood environment in vivo), all the prepared nanomaterials are negatively charged, indicating that the negatively charged nanomedicines can avoid the adsorption of proteins in vivo, can reduce the toxic effects of drugs in vivo, prolong the Circulation cycle of drugs in vivo; at pH=5.0 (simulating tumor microenvironment), MnO 2 @DOX is coated with PDA and then modified with -NH 2 make MnO 2 @DOX-NH 2 Shows strong positive charge, realizes charge inversion, and the final MnO 2 @DOX-NH 2 The -FA composite nanomedicine is positively charged, which helps the nanomedicine to aggregate to the tumor cells with negatively charged surface, so that the drug can be targeted and concentrated, which is convenient for targeted drug delivery and improves the the...

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Abstract

The invention relates to the technical field of biomedicine, in particular to a slow-release MnO coated with polydopamine 2 Nano-microsphere drug-loading system, the drug-loading system includes MnO 2 Inorganic nanoparticle carrier, specifically inorganic nano oxide MnO 2 The hollow sphere is a nano-drug platform. PDA is used to wrap the nano-hollow sphere, and FA is used as a targeting probe, so that the chemotherapeutic drug DOX can be aggregated at the tumor site to enhance the efficacy of the drug. The invention significantly improves biocompatibility, enhances the specific targeting of drugs, effectively kills tumor cells, and reduces damage to normal cells. The nanocarrier is modified to improve the pH response sensitivity and prolong the effective concentration of the drug in the blood, and the nanocarrier can be gradually decomposed in the body and excreted from the body, which is an ideal drug-carrying device for cancer treatment.

Description

technical field [0001] The invention relates to an anti-tumor nano-drug and a preparation method and application thereof, belonging to the technical field of biomedicine, in particular to a drug-loaded MnO with controlled pH release and folic acid targeting 2 Nanocomposite hollow spheres. Background technique [0002] In 2020, breast cancer has surpassed lung cancer to become the number one cancer in the world. Chemotherapy is the cornerstone of breast cancer treatment. Previous EBCTCG chemotherapy meta: Anthracyclines are the "core" of breast cancer chemotherapy, but cardiotoxicity limits the use of patients. It is particularly important to develop novel and highly effective cancer treatments with tumor targeting and reduced toxicity to normal tissues. [0003] In recent years, with the continuous development of nanotechnology, it is often used as an ideal carrier for tumor drugs due to its advantages of good biocompatibility, long in vivo cycle and strong adsorption. T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/52A61K47/54A61K31/704A61K45/00A61K47/34A61P35/00B82Y5/00
CPCA61K47/6925A61K47/6949A61K47/52A61K47/545A61K47/34A61K31/704A61K45/00A61P35/00B82Y5/00
Inventor 陈占红王晓稼陈俊青
Owner ZHEJIANG CANCER HOSPITAL
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