Sea cucumber extract for increasing bone mineral density

An extract and sea cucumber technology, applied in the field of sea cucumber extract to increase bone density, can solve the problems of low calcium absorption and availability, single mechanism of action, etc., and achieve the effect of maintaining bone health, various mechanisms of action, and balancing bone metabolism.

Pending Publication Date: 2022-05-24
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the health foods for osteoporosis on the market are mainly calcium supplement products, such as calcium-containing capsules or granules, etc. The main goal is to increase bone density by supplementing calcium in the body. The mechanism of action of these products is simple
Due to the complicated pathogenesis of osteoporosis, such as bone metabolism and calcium balance disorders, simple calcium supplementation often cannot achieve the expected effect, and due to defects in product characteristics or decline in body functions, the absorption and utilization of calcium in it is often low

Method used

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  • Sea cucumber extract for increasing bone mineral density
  • Sea cucumber extract for increasing bone mineral density
  • Sea cucumber extract for increasing bone mineral density

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1: a kind of method for preparing sea cucumber extract

[0096] A method for preparing sea cucumber extract, the method comprises the following steps:

[0097] (1) Cut the fresh sea cucumber from the abdomen, remove the visceral gonads and retain the body wall, and rinse them clean.

[0098] (2) The body wall of the sea cucumber was blanched in water above 95°C for 15 minutes, then cooled to 20°C and cut into small pieces of (1-1.5cm)*(1-1.5cm).

[0099] (3) The sea cucumber blocks are soaked in water at 0-5°C for desalination until the conductivity of the soaking solution is lower than 500us / cm.

[0100] (4) The sea cucumber block is pulverized with a colloid mill, and then put into an enzymatic hydrolysis tank together with water 8 times the weight of the sea cucumber. The liquid was heated to 95°C, kept for 30min, then cooled to 50°C, and put into the compound protease for enzymolysis. The amount of compound protease added was 0.3% of the weight of the sea...

Embodiment 2

[0105] Example 2: Application of different molecular weight sea cucumber extracts in increasing bone density

[0106] The sea cucumber extract prepared in Example 1 was used to intervene in ovariectomized rats, and animal experiments were carried out. The daily gavage amount of sea cucumber extracts with different molecular weights was 1000 mg / kg. The experimental results and conclusions are as follows:

[0107] figure 1 The data showed that the bone mineral density of the model group was significantly decreased after the operation, and the bone mineral density of the positive group was significantly increased after treatment. The BMD of ovariectomized rats also increased in each experimental group. The sea cucumber extract after enzymatic hydrolysis for 3.5h and 4.5h had better effect on BMD, which could significantly increase the BMD in rats. why figure 1 It can be seen that the sea cucumber extract does have the effect of improving bone mineral density, and the extracts a...

Embodiment 3

[0108] Example 3: Application of different doses of sea cucumber extract in increasing bone density

[0109] Based on the results of Example 2, experiments were carried out using the sea cucumber extract with an enzymatic hydrolysis time of 3.5 h in Example 1.

[0110] (1) Animal test results

[0111] The 90-day feeding test showed that the experimental animals grew in good condition throughout the growth cycle. Except for bone mineral density-related indexes, the experimental group had no significant difference with the control group in apparent physiological indexes, serum biochemical indexes, organ index indexes and pathological sections. It is confirmed that the present invention is safe and non-toxic to the body.

[0112] The present invention further details its beneficial effect on increasing bone density through animal experiments. Opinion draft)”.

[0113] The experimental scheme and results of increasing bone density function provided by the present invention are ...

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Abstract

The invention discloses a sea cucumber extract for increasing bone mineral density, and belongs to the technical field of health food. The method comprises the following steps: crushing sea cucumbers, carrying out enzymolysis, and carrying out enzyme deactivation, centrifugation, filtration and drying on enzymatic hydrolysate to obtain the sea cucumber extract. The sea cucumber extract with the function of increasing the bone mineral density contains various beneficial components such as sea cucumber polypeptide and sea cucumber polysaccharide, has various action mechanisms, can balance bone metabolism conditions from multiple aspects and promote absorption of substances such as calcium by an organism, and has a synergistic effect. The traditional Chinese medicine composition has the effects of promoting absorption and deposition of mineral elements, inhibiting inflammation in bones, balancing bone metabolism and repairing and promoting bones and bone joints, so that the bone health of a human body is maintained. In addition, after the sea cucumber extract and the calcium ions are compounded, the sea cucumber extract and the calcium ions have a synergistic effect in the aspect of improving the bone mineral density in the rat body.

Description

technical field [0001] The invention relates to a sea cucumber extract for increasing bone density, belonging to the technical field of health food. Background technique [0002] Osteoporosis is a disease caused by a variety of factors that can lead to a decrease in bone density and bone quality, destruction of bone microarchitecture, and an increased risk of fractures. Osteoporosis patients are mostly elderly and postmenopausal women, and their lives are very inconvenient, with increased bone fragility and increased risk of fractures. Osteoporosis is not easy to treat due to its various causes. With the intensification of the aging society, the incidence of osteoporosis has become higher and higher, not only the patients themselves suffer from the pain, but also the related needs for treatment and nursing, which is a need in our country and even in the world. issues of focus. [0003] There are many active substances in sea cucumber, such as collagen, polysaccharides, et...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/616A61P19/10A61P19/08A23L33/10A23L17/20A61K33/10A61K33/14
CPCA61K35/616A61K33/10A61K33/14A61P19/10A61P19/08A23L33/10A23L17/20A23V2002/00A61K2300/00A23V2200/306A23V2250/2042
Inventor 周鹏刘大松陈哲彬胡炜崔颖
Owner JIANGNAN UNIV
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