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Glycine preparation method for reducing iminodiacetic acid content

A technology of iminodiacetic acid and glycine, which is applied in the preparation of carboxylic acid nitrile, the preparation of organic compounds, the preparation of cyanide reaction, etc., can solve the problems of high iminodiacetic acid content and difficult separation, and reduce the amount of urea added. The effect of avoiding separation problems

Pending Publication Date: 2022-05-24
LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In view of this, the purpose of the present invention is to provide a glycine preparation method for reducing the content of iminodiacetic acid, which solves the problems of high iminodiacetic acid content and difficult separation in the existing glycine preparation method

Method used

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  • Glycine preparation method for reducing iminodiacetic acid content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 (add 0.2 equivalent of ammonium bicarbonate; in hydroxyacetonitrile, the same below)

[0036] Mix 31.93g ammonium bicarbonate (99w%) carbon source stabilizer with 680g ammonia water (25w%) to obtain ammonia source liquid flow, measure 175.5g hydroxyacetonitrile (65w%, pH=4) as the hydroxyacetonitrile liquid flow, respectively pass through The material pump pumps the ammonia source liquid flow and the hydroxyacetonitrile liquid flow into the static mixer to mix and then send it to the tubular reactor. The ammoniation reaction is carried out at 115 ° C and the pressure of 1.3 MPa. The reaction residence time is 4 minutes. The glycine nitrile stabilized solution was obtained from the exit of the tubular reactor. HPLC analysis showed that no obvious iminodiacetonitrile was detected. In the product, aminoacetonitrile accounted for 82.6%, and hydantoin, carbamoylacetonitrile and other stable components accounted for 17.2%. %. The structural formulas of hydantoin an...

Embodiment 2

[0037] Example 2 (adding 0.2 equivalent of carbon dioxide)

[0038] Feed 17.6g carbon dioxide gas (0.4mol) carbon source stabilizer and mix with 680g ammonia water (25w%) to obtain ammonia source liquid flow, measure 175.5g hydroxyacetonitrile (65w%, pH=4) as the hydroxyacetonitrile liquid flow, respectively pass through The material pump pumps the ammonia source liquid flow and the hydroxyacetonitrile liquid flow into the static mixer to mix and then send it to the tubular reactor. The ammoniation reaction is carried out at 115 ° C and the pressure of 1.3 MPa. The reaction residence time is 3 minutes. Glycine nitrile stable solution was obtained from the exit of the tubular reactor. HPLC analysis showed that iminodiacetonitrile accounted for about 0.2%, aminoacetonitrile accounted for 86.4%, and hydantoin, carbamoylacetonitrile and other stable components accounted for 13.3%. %.

Embodiment 3

[0039] Example 3 (adding 0.15 equivalent of urea)

[0040] Mix 18.2g urea (99w%) carbon source stabilizer with 680g ammonia water (25w%) to obtain ammonia source liquid flow, measure 175.5g hydroxyacetonitrile (65w%, pH=2) as the hydroxyacetonitrile liquid flow, respectively pass through the material pump The ammonia source liquid flow and the hydroxyacetonitrile liquid flow are pumped into the static mixer and mixed, and then sent to the tubular reactor, and the ammoniation reaction is carried out at 130 ° C and the pressure of 1.8 MPa. The reaction residence time is 1 minute, and the reaction ends. Glycine nitrile stabilized liquid was obtained from the outlet of the reactor. HPLC analysis showed that no obvious iminodiacetonitrile was detected. The aminoacetonitrile accounted for 92.2% of the product, and hydantoin, carbamoylacetonitrile and other stable components accounted for 7.6%.

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Abstract

The invention relates to the technical field of organic chemical industry, in particular to a glycine preparation method for reducing the content of iminodiacetic acid, which comprises the following steps: adding a carbon source stabilizer in the ammoniation process of hydroxyacetonitrile and an ammonia source, reacting to obtain a glycine nitrile stabilizing solution, and hydrolyzing the glycine nitrile stabilizing solution to obtain glycine. The glycine nitrile stabilizing solution contains hydantoic acid amide and / or carbamyl acetonitrile, and the proportion of iminodiacetonitrile is not higher than 0.3%. The carbon source stabilizer is added in the glycolonitrile ammoniation process, so that the generation of iminodiacetonitrile in the ammoniation process can be reduced or even avoided, the main components of the obtained glycine nitrile stabilizing solution basically containing no iminodiacetonitrile are aminoacetonitrile, hydantoic acid amide and / or carbamyl acetonitrile, and the main components can be converted into glycine in the subsequent reaction; therefore, the generation of iminodiacetic acid and the accompanying separation problem are avoided.

Description

technical field [0001] The invention relates to the technical field of organic chemical industry, in particular to a method for preparing glycine for reducing the content of iminodiacetic acid. Background technique [0002] Glycine (abbreviated as GLY), also known as amino acetic acid or acetine, is an α-amino acid with the smallest relative molecular mass and the simplest structure. It is widely used in pesticide, chemical, pharmaceutical, daily chemical, food and other industries. [0003] At present, glycine is mainly obtained by chemical synthesis method in industry. According to different processes, it can be mainly divided into chloroacetic acid method, Strecker method, improved Strecker method, and direct hydantoin method. The chloroacetic acid method uses chloroacetic acid and ammonia as raw materials, and obtains glycine and by-product salt ammonium chloride under the action of urotropine. It also has the problems of long reaction time, large consumption of catalys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/26C07C229/08C07C253/30C07C255/25
CPCC07C227/26C07C253/30C07C229/08C07C255/25Y02P20/584
Inventor 廖常福周荣超彭启明周振宇吴传隆赵加丽杨晓泉
Owner LUFENG TIANBAO PHOSPHORUS CHEM CO LTD
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