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Method for specifically blocking generation of human neutrophil lineage and application

A neutrophil and species-specific technology, which is applied in the production of bulk chemicals, organic chemistry, antineoplastic drugs, etc., can solve the problem of no corresponding application of lipoic acid, and achieve the effect of low cost and simple method

Inactive Publication Date: 2022-05-27
董勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, lipoic acid has no corresponding application in the regulation of human blood lineage and the treatment of blood diseases

Method used

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  • Method for specifically blocking generation of human neutrophil lineage and application
  • Method for specifically blocking generation of human neutrophil lineage and application
  • Method for specifically blocking generation of human neutrophil lineage and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A method that specifically blocks the production of human neutrophil lineages by using lipoic acid and lipoic acid modified small molecules to specifically block the production of human neutrophil lineages.

[0016] The lipoic acid modified small molecule is produced by the amide reaction of lipoic acid with amino acids or amino acid-like amino acids, and the specific production process is as follows:

[0017]

[0018] Amino acids include glycine, alanine, valine, leucine, isoleucine, methionine (methionine), proline, tryptophan, serine, tyrosine, cysteine, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, glutamic acid, lysine, arginine, and histidine.

[0019] Lipoic acid modified small molecules are lipoamide amino acids, specifically including lipolymide glycine, lipolyamide alanine, lipoamide valine, lipoamide leucine, lipoamide isoleucine, lipoamide methionine (methionine), lipoamide proline, lipoamide tryptophan, lipoamide serine, lipoa...

Embodiment 2

[0022]A method that specifically blocks the production of human neutrophil lineages by using lipoic acid and lipoic acid modified small molecules to specifically block the production of human neutrophil lineages.

[0023] The lipoic acid modified small molecule is produced by the reaction of lipoic acid with an alkali or alkaline hydrochloric acid base, the specific production process is as follows:

[0024]

[0025] Lipoic acid modified small molecule is lipoate; the base or alkaline salt comprising: potassium hydroxide, sodium hydroxide, sodium carbonate, sodium bicarbonate.

Embodiment 3

[0027] An application that specifically blocks the generation of human neutrophil lineages, and applies lipoic acid and lipoic acid modified small molecules to specifically block the production of human neutrophil lineages in the treatment of myeloid leukemia.

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Abstract

The invention discloses a method for specifically blocking generation of a human neutrophil lineage and application. The generation of the human neutrophil lineage is specifically blocked by adopting lipoic acid and lipoic acid modified small molecules. The lipoic acid modified small molecules are generated through an amidation reaction of lipoic acid and amino groups of amino acids; the lipoic acid modified small molecules are generated through a reaction of lipoic acid and alkaline hydrochloric acid; the lipoic acid and lipoic acid modified small molecules are used for specifically blocking the generation of human neutrophil lineage and are applied to the treatment of myelogenous leukemia. The generation of the human neutrophil lineage can be specifically blocked by utilizing the lipoic acid and the modified small molecules thereof, and the method is simple, effective, safe and low in cost. Modification is carried out on the basis of the structure of lipoic acid, so that the in-vivo application of lipoic acid modified micromolecules in blocking human neutrophil and the potential treatment application of the lipoic acid modified micromolecules in blood diseases such as myelogenous leukemia can be greatly improved.

Description

Technical field [0001] The present invention relates to the field of lipoic acid application technology, specifically refers to a method and application that specifically blocks the generation of human neutrophil lineages. Background [0002] Lipoic acid is mainly a small molecule that naturally exists in cells, which has no carcinogenic, small toxic side effects and other effects. In order to improve the role of lipoic acid in the body, small molecule modifications can be performed by carboxyl groups of lipoic acid. At present, there is no corresponding application of lipoic acid in the regulation of human blood lineage and the treatment of blood diseases. Abnormal differentiation of neutrophils and monocytes is prevalent in acute myeloid leukemia in humans. Exploring a method that can specifically block neutrogens or monocytes will benefit the treatment of acute myeloid leukemia in humans. [0003] Therefore, there is an urgent need for a method and application to specifically ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D339/04A61P35/02
CPCC07D339/04A61P35/02Y02P20/55
Inventor 董勇张益萌
Owner 董勇