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Complexing agent for treating vessel malformation as well as preparation method and application of complexing agent

A composite agent and deformed technology, applied in the field of medicine, can solve problems such as easy dilution and short action time, and achieve good therapeutic effect, good effect, safe and effective treatment effect

Pending Publication Date: 2022-05-31
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that the existing pingyangmycin in the background technology is easily diluted in local tissues and has a short action time, the present invention provides a compound agent for treating vascular malformations

Method used

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  • Complexing agent for treating vessel malformation as well as preparation method and application of complexing agent
  • Complexing agent for treating vessel malformation as well as preparation method and application of complexing agent
  • Complexing agent for treating vessel malformation as well as preparation method and application of complexing agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A compound agent for treating vascular malformation, which consists of fibrin adhesive and pingyangmycin compound agent.

[0034] The fibrin adhesive is composed of lyophilized human fibrinogen, lyophilized human thrombin, 4ml sterilized water for injection, 4ml calcium chloride aqueous solution and glycine, trishydroxymethylaminomethane, sodium chloride, citrate Sodium, sucrose composition. Wherein, the sterilized water for injection is used to dissolve freeze-dried human fibrinogen, and the aqueous calcium chloride solution is used to dissolve freeze-dried human thrombin. Glycine, tris, sodium chloride, sodium citrate and sucrose were used as excipients.

[0035] The pingyangmycin complex contains 8 mg of pingyangmycin freeze-dried powder and 2 mg of sapelin freeze-dried powder. Pingyangmycin freeze-dried powder and Sapelin freeze-dried powder were dissolved in 5 mg / ml dexamethasone.

Embodiment 2

[0037] A preparation method for the compound agent for treating vascular malformation as described in embodiment 1, the steps are specifically:

[0038] S1. Configuration of Fibrin Adhesive

[0039] Add freeze-dried human fibrinogen into the container according to the formula, and place it in a water bath at 30-37°C to warm it. Then add sterile water for injection into the container containing the fibrinogen, place the container in a water bath to warm up, and shake the bottle gently to avoid air bubbles. After the fibrinogen is completely dissolved, a fibrinogen solution is obtained.

[0040] Put freeze-dried human thrombin and calcium chloride aqueous solution into containers respectively, and heat to room temperature. Add calcium chloride aqueous solution to the container containing thrombin according to the formula, shake the bottle gently to dissolve the thrombin to prepare a thrombin solution.

[0041] In the process of preparing fibrin adhesive, the syringe and needl...

Embodiment 3

[0047] Present embodiment is the compound agent of the present invention in the actual treatment process of 42 patients, wherein the example of a patient, specific content is as follows:

[0048] A male patient, 35 years old, suffered from arteriovenous malformation and swelling of the right cheek for more than 10 years.

[0049] History of present illness: The patient experienced mild swelling of the right cheek more than 10 years ago without obvious incentives, no local skin redness, fever, pain and other discomfort, and no treatment was given. In the past 2 years, there was no obvious incentive for the swelling of the right cheek to increase, and then a mass gradually formed in the right parotid gland area, so he went to see a doctor.

[0050] Past history: usually in good health, denying high blood pressure, denying diabetes, denying coronary heart disease. Denies any history of hepatitis, tuberculosis and other infectious diseases, surgery, trauma, blood transfusion hist...

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PUM

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Abstract

The invention provides a complexing agent for treating vascular malformation and a preparation method and application thereof, and belongs to the technical field of medicines. The complexing agent is composed of a fibrous protein adhesive and a pingyangmycin complexing agent, and the pingyangmycin complexing agent comprises pingyangmycin freeze-dried powder, sapponin freeze-dried powder and dexamethasone. Compared with the prior art, the complexing agent disclosed by the invention has the beneficial effects that the complexing agent for treating the vascular malformation is a sustained-release preparation formed by combining pingyangmycin, sapponin and a fibrin adhesive, is safe and effective in treatment of the vascular malformation, and has a better treatment effect; and particularly, the traditional Chinese medicine has a better effect on vein malformation, lymphatic vessel malformation and arteriovenous malformation.

Description

technical field [0001] The invention relates to the technical field of medicines, and more specifically relates to a compound agent for treating vascular malformations, so as to improve the curative effect of oral and maxillofacial vascular malformations. Background technique [0002] The vascular system is mainly composed of blood vessels and lymphatic vessels, which undertake important physiological functions of the human body. Vascular disease refers to the abnormal proliferation, communication or morphological changes of the vascular system caused by various factors. Vascular diseases can occur in any tissue and part of the human body, and often exhibit aggressive or even malignant growth characteristics, which are extremely harmful to health. Vascular diseases that occur in the extremities, body surface or face can not only affect the appearance, but also form space occupying with irregular borders, oppress or invade adjacent tissues and organs, and lead to loss of nor...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61P9/14A61K38/36A61K38/14A61K35/744A61K31/573
CPCA61K38/14A61K35/744A61K31/573A61K38/363A61K38/4833A61K9/0019A61P9/14C12Y304/21005A61K2300/00
Inventor 何倩婷王安训曹琮沅
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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