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Body implant with filler and preparation method thereof

A technology of fillers and implants, applied in joint implants, joint implants, prostheses, etc., can solve the problem of discontinuity of fillers in honeycomb structure, accelerated degradation of instruments and premature failure, difficult connection strength of honeycomb structures, etc. problems, to achieve excellent mechanical properties and biochemical properties, reduce internal stress, improve strength and rigidity

Pending Publication Date: 2022-06-03
苏州卓恰医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, for some degradable medical devices that need to be implanted in the body, the honeycomb structure will lead to accelerated degradation and premature failure of the device, and the pure metal honeycomb structure is not conducive to the regeneration of blood vessels and tissues
If the honeycomb structure is filled with bioactive materials, although the above problems can be solved, the filler is discontinuous in the honeycomb structure, and it is difficult to maintain a certain connection strength with the honeycomb structure.

Method used

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  • Body implant with filler and preparation method thereof
  • Body implant with filler and preparation method thereof

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preparation example Construction

[0028] On the other hand, the present invention also relates to a preparation method for preparing a preferred embodiment of the present invention, comprising:

[0029] Step 1: The peripheral structure 1 and the skeleton structure 2 are processed by using magnesium or magnesium alloy, and the peripheral structure 1 and the skeleton structure 2 are connected to build a honeycomb structure that is sealed around and has a filling space.

[0030] Step 2: Inject filler 3. After mixing and stirring the filler 3, that is, the bone cement, the filler 3 is injected into the filling space formed by the peripheral structure 1 and the skeleton structure 2 through the five injection ports 4 on the upper outer sealing plate 12, and is allowed to stand. Curing for 1 to 2 hours. The injection pressure is 0.2-0.6MPa, the injection time is controlled within 30 minutes, and the filling rate of bone cement is 80%-90%. Due to the mesh design of the support wall 21, the injection pressure can be r...

Embodiment 1

[0039] In this embodiment, the skeleton structure 2 and the peripheral structure 1 are both pure magnesium materials, and the filler 3 is calcium phosphate bone cement

[0040] In this embodiment, the formula of calcium phosphate bone cement is: powder weight ratio: tetracalcium phosphate 30% to 40%, anhydrous calcium hydrogen phosphate 30% to 40%, boric acid 1% to 5%, liquid: remove Ionized water is 10% to 30%; the purity of the tetracalcium phosphate is 99%, and the powder particle size is 30 to 70 μm; the purity of anhydrous calcium hydrogen phosphate is 99%, and the particle size is 30 to 70 μm; the conductivity of deionized water is less than 0.5us / cm; Retarder) with a purity of 99% and a particle size of 30-70 μm.

Embodiment 2

[0042] In this embodiment, the skeleton structure 2 and the peripheral structure 1 are both magnesium alloy materials, and the filler 3 is magnesium phosphate bone cement.

[0043] In this embodiment, the formula of magnesium phosphate bone cement is: magnesium phosphate bone cement, and the weight ratio of powder is: magnesium oxide 33%-55%, potassium dihydrogen phosphate 10%-15%, sodium dihydrogen phosphate 5%- 10%, boric acid 1% to 5%, liquid weight ratio: deionized water 10% to 20%; the magnesium oxide is fused magnesium oxide, the purity of magnesium oxide is 98%, the sintering temperature is 2700 ° C, and the particle size of magnesium oxide powder is 30 ~70μm; sodium dihydrogen phosphate purity 99%, particle size 30-70μm; sodium dihydrogen phosphate purity 99%, particle size 30-70μm; deionized water conductivity <0.5us / cm; boric acid (retarder) purity 99%, The particle size is 30~70μm.

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Abstract

The body implant with the filler is characterized by comprising a peripheral structure, a skeleton structure, the filler and an injection port. Wherein the framework structure comprises a plurality of supporting walls, and the supporting walls are mutually spliced to form a structure with the upper top face and the lower bottom face being in a honeycomb shape; the supporting wall is of a porous net-shaped structure; the supporting walls located on the edges of the framework structure are connected with the peripheral structure, and a filling space with the upper top face and the lower bottom face communicated and the periphery closed is jointly formed in the space defined by the peripheral structure and the framework structure and used for containing the filler. The injection port is formed in the peripheral structure or the framework structure and used for injecting filler. The invention also discloses a preparation method of the body implant. The preparation method comprises the following steps: processing and connecting the peripheral structure and the skeleton structure, injecting the filler, and sintering at low temperature. The body implant provided by the invention has excellent mechanical properties, generates less gas during degradation, and has excellent biological activity and osteogenic induction ability.

Description

technical field [0001] The present invention relates to the field of medical devices, in particular to a body implant with fillers that can be used to manufacture medical devices and a preparation method thereof. Background technique [0002] The honeycomb structure originated from bionics and is a combined structure with regular hexagons without gaps. This structure has excellent mechanical properties such as light weight, low density, high strength, good rigidity and impact resistance. It is widely used in building materials, Aerospace manufacturing, transportation equipment, etc. For example, patent CN201710428356.9 discloses a magnesium alloy helmet using honeycomb reinforcing ribs. The invention adopts a magnesium alloy skeleton with a honeycomb structure, which greatly reduces the weight of the helmet skeleton on the basis of good impact resistance. In the field of medical devices, if the characteristics of the honeycomb structure are used, some biologically active or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/70A61B17/80A61F2/30A61L27/04A61L27/12A61L27/56A61L27/58
CPCA61B17/7061A61B17/7064A61B17/80A61F2/30771A61F2/30942A61L27/047A61L27/12A61L27/58A61L27/56A61L2430/02A61F2002/30784A61F2002/30062A61F2002/3006A61F2002/30968A61B2017/00004A61B2017/00526
Inventor 杨玮宫海波肖杰
Owner 苏州卓恰医疗科技有限公司