Preparation method of nano material for imaging and tumor treatment

A nanomaterial and composite nanomaterial technology, applied in chemical instruments and methods, medical preparations containing active ingredients, luminescent materials, etc., can solve problems such as single action, side effects, tumor resistance, etc. simple effect

Active Publication Date: 2022-06-03
LANZHOU UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at problems such as the single effect of existing drugs, side effects and tumor drug resistance, the purpose of the present invention is to pr

Method used

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  • Preparation method of nano material for imaging and tumor treatment
  • Preparation method of nano material for imaging and tumor treatment
  • Preparation method of nano material for imaging and tumor treatment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 A kind of preparation method of MOF and long afterglow composite material

[0040] Preparation of nanometer long afterglow materials:

[0041] Take Zn(NO 3 ) 2 ·6H 2 O,Ga(NO 3 ) 3 ·H 2 O and Cr (NO 3 ) 3 ·9H 2 0 Mix and dissolve in a mixed solution of 0.5 mL of water and 0.5 mL of ethanol, add 100 mg of nano-mesoporous silica powder, and ultrasonically vibrate for 2 h to fully mix the mixed solution and silica to obtain a colloidal mixture. The mixture was dried in an oven at 60°C for 12h. The obtained white powder was fully ground in a mortar, transferred into a corundum crucible, placed in a muffle furnace, and calcined at 800° C. for 3 hours. After the end, the powder was ground and stored to obtain nanoparticle SZGO.

[0042] Nanoparticle Surface Supported MOFs Materials

[0043] 200 mg of CuCl 2 Solution A was prepared by dissolving in ultrapure water, and 174 mg of mes-tribenzoic acid was completely dissolved in ethanol to prepare solutio...

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Abstract

The invention designs a Cu-MOF material and long afterglow material combined composite nanomaterial for biological imaging and tumor treatment, the chemical formula of the composite nanomaterial is SiO2 (at) Zn1 + xGa1.9-x-yO4: Cr (y) (at) HKUST-1, x is more than or equal to 0 and less than or equal to 0.2, and y is more than or equal to 0.001 and less than or equal to 0.015. The prepared composite nano material can show good near-infrared luminescence in a mouse body, and can achieve the effect of completely curing mouse tumors through synergistic treatment of a chemical kinetic therapy and a photothermal therapy.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a nanomaterial combined with a MOF and a long afterglow material for biological imaging and tumor treatment and a preparation method thereof. Background technique [0002] Cancer is currently one of the major diseases threatening human life because of its complex etiology, high morbidity and high mortality. Traditional cancer treatment methods mainly include surgery, drugs, and radiation therapy. But most treatments damage healthy tissue and are less effective due to low oxygen, low pH, and high intracellular expression of substances in the tumor microenvironment. Therefore, it is of great significance to explore new therapeutic methods to avoid these disadvantages. [0003] In order to solve these problems, a design study was carried out in this paper, combining long afterglow materials with MOFs materials, using long afterglow nanomaterials with non-toxic and good near-...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00A61K49/00B82Y5/00B82Y40/00C09K11/62C09K11/06
CPCA61K41/0052A61P35/00A61K49/0013B82Y5/00B82Y40/00C09K11/623C09K11/06C09K2211/188Y02E60/36
Inventor 刘伟生俞彬王畇鉴王文杰
Owner LANZHOU UNIVERSITY
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