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Preparation and application of compound traditional Chinese medicine composition for regulating tumor immunity and resisting tumors

A technology of compound traditional Chinese medicine and composition, applied in the field of traditional Chinese medicine, can solve the problems of the traditional Chinese medicine composition that does not regulate tumor immune checkpoint protein and the large dosage, and achieves inhibiting tumor cell growth, reducing pain, and promoting tumor cell apoptosis. Effect

Active Publication Date: 2022-06-07
SHENGJING HOSPITAL OF CHINA MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage of traditional Chinese medicine composition used for anti-tumor treatment is relatively large, and there is no report on the traditional Chinese medicine composition that regulates tumor immune checkpoint proteins and improves tumor immunity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] According to the number of parts by weight, take the raw materials, take 15 grams of Ganoderma lucidum, 25 grams of astragalus, 15 grams of ginseng, 15 grams of fried Atractylodes, 15 grams of Poria, 15 grams of Angelica, 15 grams of Sophora flavescens, and 15 grams of licorice. According to the weight of compound traditional Chinese medicine, add water 12 times, i.e. 1560mL, for a total of decocting, extract 3 times, 2 hours each time, filter naturally through a 120-mesh stainless steel mesh, put the concentrate on a macroporous adsorption resin column, elute and concentrate under reduced pressure to determine relative The extract with a density of 1.20-1.30 is vacuum-dried, ultra-finely pulverized at low temperature to obtain fine powder, added with diluent lactose and cornstarch, mixed evenly, packed into enteric-coated capsules, and prepared into compound traditional Chinese medicine capsules. (Lot number: T001).

Embodiment 2

[0038] According to the number of parts by weight, take the raw materials, take 10 grams of Ganoderma lucidum, 20 grams of astragalus, 10 grams of ginseng, 10 grams of fried Atractylodes, 10 grams of Poria, 10 grams of Angelica, 10 grams of Sophora flavescens, and 10 grams of licorice. Add water 10 times the weight of the compound traditional Chinese medicine, that is, 900 mL of water for a total of decocting, extract 3 times, 2 hours each time, naturally filter through a 120-mesh stainless steel mesh, and attach the concentrate to a macroporous adsorption resin column. The extract with the relative density of 1.20-1.30, after vacuum drying, ultra-finely pulverized at low temperature to obtain fine powder, adding microcrystalline cellulose, sodium carboxymethyl starch, and adding lubricant magnesium stearate, after mixing uniformly, tableting preparation into tablets. (Lot number: T002).

Embodiment 3

[0040]Take the raw materials by weight, take 5 grams of Ganoderma lucidum, 15 grams of astragalus, 5 grams of ginseng, 5 grams of fried Atractylodes, 5 grams of Poria, 5 grams of Angelica, 5 grams of Sophora flavescens, and 5 grams of Zhigancao. According to the weight of the compound traditional Chinese medicine, add 8 times the weight of 70% ethanol solution, that is, 400 mL ethanol solution for reflux extraction, extract 3 times, 2 hours each time, filter naturally through a 120-mesh stainless steel mesh, and place the concentrate on a macroporous adsorption resin column. After elution, further Concentrate under reduced pressure into an extract with a relative density of 1.20-1.30. After vacuum drying, it is ultra-finely pulverized at low temperature to obtain a fine powder. Excipients and binders such as acrylate polymers and polyethylene glycol are added, and the melting method is adopted. Prepared in drop pill form. (Lot number: T003).

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a compound traditional Chinese medicine composition for regulating tumor immunity and resisting tumors as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of lucid ganoderma, 15-25 parts of astragalus membranaceus, 5-15 parts of ginseng, 5-15 parts of roasted rhizoma atractylodis macrocephalae, 5-15 parts of poria cocos, 5-15 parts of angelica sinensis, 5-15 parts of radix sophorae flavescentis and 5-15 parts of honey-fried licorice root. The compound traditional Chinese medicine composition provided by the invention has the effects of combining purgation and tonification, replenishing qi and enriching blood, detoxifying and removing stasis, regulating tumor immunity, resisting tumors and the like, can regulate and control tumor immune checkpoint proteins, has a killing effect on various tumor cells, can regulate the proportion of a plurality of T lymphocyte subpopulations, causes remarkable increase of immunocompetent cells, and has a remarkable curative effect on tumor cells. The immune function is enhanced, and the effect of treating tumors is achieved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a compound traditional Chinese medicine composition preparation for regulating tumor immunity and anti-tumor. Background technique [0002] Cancer is a major disease that seriously threatens human life and health. According to the World Health Organization, there will be 9.96 million cancer deaths worldwide in 2020, of which nearly 3 million occurred in China. The clinical treatment of tumors mainly relies on the methods of radiotherapy and chemotherapy. Taking chemotherapy as an example, chemotherapeutic drugs are highly toxic. They kill tumor cells and autoimmune cells such as white blood cells and lymphocytes at the same time, resulting in the destruction of the patient's autoimmune function and serious adverse reactions. On the other hand, tumor-targeted drugs work on specific targets, but due to the different genotypes of each patient, thei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489
CPCA61K36/074A61K36/481A61K36/258A61K36/284A61K36/076A61K36/232A61K36/489A61K36/484A61P35/00A61P37/02A61P35/02A61K2236/331A61K2236/333A61K2300/00Y02A50/30
Inventor 刘彩刚杨永亮刘贺牛楠
Owner SHENGJING HOSPITAL OF CHINA MEDICAL UNIV
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