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Triazole feed additive as well as preparation method and application thereof

A technology of feed additives and triazoles, which is applied in the field of feed additive synthesis to improve the body's immunity, reduce inflammation, and improve utilization

Pending Publication Date: 2022-06-07
河南湾流生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the catalytic activity of IDO1 is much higher than that of TDO and IDO2

Method used

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  • Triazole feed additive as well as preparation method and application thereof
  • Triazole feed additive as well as preparation method and application thereof
  • Triazole feed additive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] In a reaction flask with nitrogen protection and temperature control device, 20 g of 3-methoxybenzyl bromide was added to 350 mL of acetonitrile, stirred evenly, and then cooled to 0 °C, and 250 mL of acetonitrile dissolved with 10 g of sodium azide was slowly added dropwise. After the dropwise addition, the mixture was stirred for 1 h, and then 1.9 g of cuprous iodide and 300 mL of a tert-butanol solution in which 11 g of trimethylsilylacetylene was dissolved were added to the reaction system, stirred to dissolve, and slowly heated to 50°C. 1000 mL of water was added, the reaction system was extracted with 200 mL of dichloromethane for several times, the organic phases were combined, dried over anhydrous sodium sulfate 50 g, concentrated, and separated by silica gel column chromatography to obtain 16.26 g of 3-methoxybenzyl triazole; LC-MS (ESI): m / z 190 [M+H] + .

Embodiment 2

[0022]

[0023] In a reaction flask with nitrogen protection and temperature control device, add 25 g of 3-bromobenzyl bromide into 400 mL of acetonitrile, stir evenly, and then cool down to 0 °C, slowly add 250 mL of acetonitrile dissolved with 10 g of sodium azide dropwise, and add dropwise. After stirring for 1 h, add 1.9 g of cuprous iodide and 300 mL of tert-butanol solution dissolved in 11 g of trimethylsilyl acetylene into the reaction system, stir to dissolve, slowly heat to 50 ° C, and add water to the reaction system after the reaction is completed. 1000mL, then the reaction system was extracted with 200mL of dichloromethane for several times, the organic phases were combined, dried over anhydrous sodium sulfate 50g, concentrated, and separated by silica gel column chromatography to obtain 19.04g of 3-bromobenzyltriazole; LC-MS ( ESI): m / z 237[M+H] + .

Embodiment 3

[0025]

[0026]In a reaction flask with nitrogen protection and temperature control device, add 25g of 2-bromobenzyl bromide into 400mL of acetonitrile, stir evenly, then cool down to 0°C, slowly add 250mL of acetonitrile dissolved with 10g of sodium azide dropwise, add dropwise After stirring for 1 hour, add 1.9 g of cuprous iodide and 300 mL of a tert-butanol solution in which 11 g of trimethylsilylacetylene was dissolved into the reaction system, stir to dissolve, slowly heat to 50°C, and add water to the reaction system after the reaction is completed. 1000mL, then the reaction system was extracted with 200mL of dichloromethane for several times, the organic phases were combined, dried over anhydrous sodium sulfate 50g, concentrated, and separated by silica gel column chromatography to obtain 17.12g of 2-bromobenzyltriazole; LC-MS ( ESI): m / z 237[M+H] + .

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Abstract

The invention discloses a triazole feed additive as well as a preparation method and application thereof, and belongs to the technical field of feed additive synthesis. According to the technical scheme, the triazole feed additive molecule has the structure, R1 and R2 are halogen atoms or methoxyl and other substitutions, benzyl bromide compounds are used as raw materials, the compound molecule containing the triazole structure is simply, conveniently and efficiently prepared, and the compound molecule can inhibit the activity of immune protein IDO1. The T cell level is improved, so that diseases such as animal inflammation can be relieved, the activity of urease can be inhibited, and the compound can be used as a feed additive of animals.

Description

technical field [0001] The invention belongs to the technical field of feed additive synthesis, in particular to a triazole feed additive and a preparation method and application thereof. Background technique [0002] Animal immunity is an indispensable and important link in the process of livestock and poultry breeding, and it is also the technical key to ensure the success of breeding. It has been scientifically proved that the immune function of the animal body is in many cells and molecules such as lymphocytes, killer cells, natural killer cells, mononuclear phagocytes, dendritic cells, red blood cells, granulocytes, mast cells, interferon, complement, and antibodies. done in synergy. These immune cells and immune molecules travel throughout the body through the blood, continuously perform immune functions, and annihilate the invading pathogens at any time. The comprehensive effect determines the strength of animal immunity and disease resistance. Therefore, try to eff...

Claims

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Application Information

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IPC IPC(8): C07D249/06A23K20/116
CPCC07D249/06A23K20/116Y02P20/55
Inventor 杨维晓龚晓庆毛龙飞侯延生孙格王春光
Owner 河南湾流生物科技有限公司
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