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Cetirizine hydrochloride tablet and preparation method thereof

A technology of cetirizine hydrochloride and rizine tablets, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as adhesion and agglomeration, and shelf-life content decline , to achieve the effect of being suitable for industrial production, simple preparation process and excellent detection stability

Pending Publication Date: 2022-06-24
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a cetirizine hydrochloride tablet with strong hardness, high stability and good dissolution rate, which solves the problem of adhesion and coalescence of raw materials in the tablet, decreased shelf-life content, and low dissolution rate. problems, improve the stability of product quality, the method is simple and applicable to industrial production

Method used

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  • Cetirizine hydrochloride tablet and preparation method thereof
  • Cetirizine hydrochloride tablet and preparation method thereof
  • Cetirizine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Cetirizine Hydrochloride Tablets

[0029] The prescription consists of 1000 tablets

[0030]

[0031]

[0032] Preparation Process:

[0033] (1) batching process: Cetirizine hydrochloride and fumed silica are pulverized using a 120-mesh bottom mesh;

[0034] (2) Mixing and sieving process: in the mixing and sieving process, the order of adding the raw and auxiliary materials is microcrystalline cellulose, cetirizine hydrochloride fumed silica powder, lactose, low-substituted hypromellose, and the mixing time is 5 minutes. 30 mesh sieve, mix for another 10 minutes, and then mix for 3 minutes with magnesium stearate;

[0035] (3) Tabletting process: using a rotary tablet press, tableting; the tableting speed is 150,000 tablets / hour, and the average tableting main pressure is 15.0KN;

[0036] (4) Coating process: in the coating process, the film-coating premix is ​​added to purified water, stirred for 30 minutes to prepare a suspension coating solution ...

Embodiment 2

[0037] Example 2: Cetirizine Hydrochloride Tablets

[0038] The prescription consists of 1000 tablets

[0039] Element Weight (g) cetirizine hydrochloride 10 Fumed silica 3 microcrystalline cellulose 50 lactose 65 low substituted hydroxypropyl cellulose 13 Magnesium stearate 3 Opadry 7

[0040] Preparation Process:

[0041] Same as Example 1.

Embodiment 3

[0042] Example 3: Cetirizine Hydrochloride Tablets

[0043] The prescription consists of 1000 tablets

[0044]

[0045]

[0046] Preparation Process:

[0047] Same as Example 1.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and relates to cetirizine hydrochloride tablets and a preparation method thereof. The cetirizine hydrochloride tablet is composed of one of cetirizine hydrochloride, fumed silica or aerosil, a filler, a disintegrating agent, a lubricant and a gastric-soluble film coating premix. The cetirizine hydrochloride tablet which is high in hardness, high in stability and good in dissolution rate is provided by mixing and crushing the active ingredient cetirizine hydrochloride and the preferable flow aid and optimizing the preparation process, the problems of adhesion and coalescence of raw materials and low dissolution rate in tablets are solved, and the preparation method is simple, easy to implement and suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a cetirizine hydrochloride tablet and a preparation method thereof. Background technique [0002] With the development of modern industry, air pollution has become more and more serious, and external harmful substances such as harmful gases, dust, allergenic microorganisms and allergens are directly inhaled into the lungs, causing the incidence of respiratory diseases (especially allergic rhinitis and asthma) and Mortality is increasing. Statistics show that up to 25% of the world's population suffer from various types of allergic diseases. Cetirizine hydrochloride is a second-generation H1 antihistamine, a long-acting, selective oral potent antiallergic drug. H1 receptor antagonists have good anti-allergic effects and are commonly used in allergic rhinitis, allergic skin pruritus, conjunctivitis, etc. Compared with its similar drugs such as diphenhydramine, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K47/04A61K47/38A61K31/495A61P37/08A61P11/02A61P17/04A61P27/02
CPCA61K9/2866A61K9/2054A61K9/2009A61K31/495A61P37/08A61P11/02A61P17/04A61P27/02
Inventor 苗国力刘阿利郭洪涛谢明秀
Owner LUNAN PHARMA GROUP CORPORATION
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