Activatable nano photosensitizer as well as preparation method and application thereof

A photosensitizer and nanotechnology, applied in the field of biomedicine, can solve problems such as poor photostability, insufficient water solubility, and toxic and side effects of normal tissues

Active Publication Date: 2022-06-28
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the existing defects of the above-mentioned existing photosensitizers, to solve the disadvantages of current commonly used photosensitizers such as insufficient water solubility, poor photostability, and toxic and side effects on normal tissues caused by activation of a single factor, the present invention adopts an amphiphilic polymer (dihard An activatable nano-photosensitizer was obtained by wrapping the malondialdehyde probe with fatty acylphosphatidylethanolamine-polyethylene glycol. Tumor tissue, successfully solved the toxic and side effects of current single-factor activated photosensitizers on normal tissues

Method used

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  • Activatable nano photosensitizer as well as preparation method and application thereof
  • Activatable nano photosensitizer as well as preparation method and application thereof
  • Activatable nano photosensitizer as well as preparation method and application thereof

Examples

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Embodiment 1

[0041] A preparation method of an activatable nanometer photosensitizer, comprising the following steps:

[0042] Under sonication, MDA probe (50 μg) and distearoylphosphatidylethanolamine-polyethylene glycol (5 mg) were added to tetrahydrofuran (THF), the components were mixed well, and quickly poured into deionized water. A large excess of distearoylphosphatidylethanolamine-polyethylene glycol can wrap the MDA probe as much as possible and avoid the damage of the molecular probe. After 10-15 minutes of continuous sonication, the hydrophobic MDA probe can enter the hydrophobic cavity of the amphiphilic polymer distearoylphosphatidylethanolamine-PEG, and the hydrophilic layer of the polyethylene glycol can be exposed on the particles. surface, and then the solution was evaporated by a rotary evaporator at 40-50 °C to remove excess THF. Finally, the nanophotosensitizer solution is purified 3-5 times by ultrafiltration to remove the unsuccessfully modified MDA probe, and finall...

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Abstract

The invention provides an activatable nano photosensitizer as well as a preparation method and application thereof, and the method comprises the following steps: under an ultrasonic condition, adding MDAPORBE and distearoyl phosphatidyl ethanolamine-polyethylene glycol into an organic solvent to obtain a mixed solution; and rapidly injecting the obtained mixed solution into deionized water, carrying out ultrasonic treatment for 10-15 minutes, evaporating through a rotary evaporator, and carrying out ultrafiltration purification. According to the prepared nano photosensitizer, the probe-containing MDAprobe serves as a main body, a conjugated system in molecules is changed through a nucleophilic reaction of MDA, photodynamic and photo-thermal therapy is achieved by changing absorbance, and tumor specific photodynamic and photo-thermal therapy can be achieved.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, in particular, to an activatable nano-photosensitizer and a preparation method and application thereof. Background technique [0002] Phototherapy, usually including photodynamic therapy (PDT) and photothermal therapy (PTT). Photodynamic therapy generates toxic reactive oxygen species (ROS), leading to lipid peroxidation of polyunsaturated fatty acids (PUFAs) in cell membranes, altering membrane fluidity and structure, and increasing membrane permeability, ultimately leading to a loss of membrane integrity. lost. Photothermal therapy can induce local heat shock, directly kill tumor cells, destroy tumor blood vessels, and trigger an immune response to destroy tumor cells. [0003] Currently, most traditional cyanine photosensitizers (PSs) have poor solubility and photostability, which are not suitable for further clinical practice, limiting their application in precision tumor therap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00C07D491/107A61P35/00A61K47/54A61K9/51A61K47/34A61K49/00
CPCA61K41/0057C07D491/107A61K47/545A61P35/00A61K49/0052A61K49/0021A61K49/0093A61K9/0019A61K41/0052A61K9/5153
Inventor 张晓兵马原宋国胜徐心昱
Owner HUNAN UNIV
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