Trimetazidine hydrochloride sublingual tablet pharmaceutical preparation

A technology of trimetazidine hydrochloride and trimetzidine hydrochloride, applied in the field of sublingual tablets, can solve the problem of few types of drugs, and achieve the effects of fast disintegration and dissolution rate, good sample reproducibility, and simple process preparation

Pending Publication Date: 2022-07-01
BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs treat coronary heart disease, but there are fewer types of drugs that work in a short time

Method used

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  • Trimetazidine hydrochloride sublingual tablet pharmaceutical preparation
  • Trimetazidine hydrochloride sublingual tablet pharmaceutical preparation
  • Trimetazidine hydrochloride sublingual tablet pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation Example

[0025]

[0026] Preparation Process:

[0027] (1) 2 parts of trimetazidine hydrochloride was mixed with 1.5 parts of sodium saccharin and 1.5 parts of tartaric acid, and then mixed with 68 parts of mannitol.

[0028] (2) Add 1 part of sodium carboxymethyl cellulose, 0.2 part of cherry essence and 0.8 part of sodium stearyl fumarate to the above mixed powder, and mix uniformly.

[0029] (3) Pressing the above-mentioned total powder with a 5mm round punch, the tablet weight is 75mg and the hardness is 2-3kg.

Embodiment 2

[0030] Example 2: Preparation Example

[0031]

[0032]

[0033] Preparation Process:

[0034] (1) 2 parts of trimetazidine hydrochloride was mixed with 1 part of sodium saccharin and 1 part of tartaric acid, and then mixed with 69.9 parts of mannitol.

[0035] (2) Add 3 parts of sodium carboxymethyl cellulose, 0.2 part of cherry essence and 1 part of sodium stearyl fumarate to the above mixed powder, and mix uniformly.

[0036] (3) Pressing the above-mentioned total powder with a 5mm round punch, the tablet weight is 75mg and the hardness is 2-3kg.

Embodiment 3

[0037] Example 3: Preparation Example

[0038]

[0039] Preparation Process:

[0040] (1) 2 parts of trimetazidine hydrochloride was mixed with 0.8 parts of sodium saccharin and 1.2 parts of tartaric acid, and then mixed with 65 parts of mannitol.

[0041] (2) Add 1 part of sodium carboxymethyl cellulose, 0.2 part of cherry essence and 0.8 part of sodium stearyl fumarate to the above mixed powder, and mix uniformly.

[0042] (3) Pressing the above-mentioned total powder with a 5mm round punch, the tablet weight is 75mg and the hardness is 2-3kg.

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Abstract

The invention relates to a trimetazidine hydrochloride tablet preparation, in particular to a sublingual tablet containing trimetazidine hydrochloride medicine, which contains trimetazidine hydrochloride, at least one diluent, at least two flavoring agents, at least one taste masking agent, at least one disintegrating agent and at least one lubricant, and the preparation contains 2mg of trimetazidine hydrochloride. The trimetazidine hydrochloride sublingual tablet in a specific proportion meets the requirements of a sublingual tablet preparation in quality, and has high disintegration and dissolution rates. Other advantages of the pharmaceutical preparation include simple process preparation. The invention further relates to a preparation method of the trimetazidine hydrochloride tablet, a sample prepared by the method is good in reproducibility, and the quality of the sample conforms to relevant regulations of sublingual tablets.

Description

technical field [0001] The present invention relates to trimetazidine hydrochloride tablet preparations, in particular to a sublingual tablet containing trimetazidine hydrochloride. Background technique [0002] The oral route of administration is the most common way of current medication, but of course this method also has some disadvantages, such as first-pass effect, reduced bioavailability, slow onset of action, and difficulty in swallowing after taking the drug. If the therapeutic effect of the drug is a sudden disease, the onset of action is required to be fast, and the sublingual tablet is the optimal dosage form. Sublingual tablet is a kind of tablet that is used under the oral cavity. Using saliva, the tablet disintegrates rapidly in the oral cavity, and the drug is absorbed through the oral mucosa. The absorbed drug directly enters the systemic circulation and is distributed throughout the body without first-pass effect. [0003] After taking ordinary tablets, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/22A61K47/12A61K47/46A61K47/38A61K31/495A61P9/10
CPCA61K9/006A61K9/2095A61K9/2018A61K9/2013A61K9/2068A61K9/2054A61K31/495A61P9/10
Inventor H.J.乔海盟王苗赵阳
Owner BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD
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