Inositol nicotinate orally disintegrating tablet and preparation method thereof

A technology of inositol nicotinate and orally disintegrating tablets, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Not high, poor compliance, etc.

Pending Publication Date: 2022-07-01
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the disadvantages of the ordinary tablet of inositol nicotinate for those with dysphagia, such as poor compliance, low bioavailability, and bitter taste, it is difficult to make oral preparations. Another problem with oral administration is the absorption of the drug in the blood after swallowing Speed ​​varies by patient

Method used

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  • Inositol nicotinate orally disintegrating tablet and preparation method thereof
  • Inositol nicotinate orally disintegrating tablet and preparation method thereof
  • Inositol nicotinate orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] An orally disintegrating tablet of inositol nicotinate is made from the components comprising the following weight percentages:

[0009]

[0010] A method for preparing the above-mentioned inositol nicotinate orally disintegrating tablets by wet granulation, comprising the steps:

[0011] Pulverize the inositol nicotinate through a 200-mesh sieve, use 20% of the prescription amount of purified water as a solvent, configure the raw material drug and the prescription amount of a penetration enhancer solution as a wetting agent, add the materials and mix them, add the bulk drug solution, and sieve with a 40-mesh sieve. The dried granules were dried by blast at 50°C, and the moisture content was dried to 1~3%. The dried granules were sieved through a 30-mesh sieve and weighed to calculate the yield. Magnesium fatty acid, Φ6 flat punched tablet, tablet weight 150 mg, hardness 20-40 N.

Embodiment 2

[0013] An orally disintegrating tablet of inositol nicotinate is made from the components comprising the following weight percentages:

[0014]

[0015] A method for preparing the above-mentioned inositol nicotinate orally disintegrating tablets by wet granulation, comprising the same steps as in Example 1.

Embodiment 3

[0017] An orally disintegrating tablet of inositol nicotinate is made from the components comprising the following weight percentages:

[0018]

[0019] A method for preparing the above-mentioned inositol nicotinate orally disintegrating tablets by wet granulation, comprising the same steps as in Example 1.

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Abstract

The invention relates to the technical field of medicines, in particular to an inositol nicotinate orally disintegrating tablet and a preparation method thereof, and is characterized in that the inositol nicotinate orally disintegrating tablet contains inositol nicotinate, and also contains a filler, a penetration enhancer, a disintegrating agent, a lubricant and a flavoring agent. In addition, the disclosed preparation method adopts wet granulation, the technical process is stable and mature, the preparation process is simple, and the preparation method is suitable for large-scale production. The inositol nicotinate orally disintegrating tablet provided by the invention has the advantages of capability of increasing absorption of medicines through mucosal tissues, rapidness in disintegration, excellent taste, no grit feeling, good compliance and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an orally disintegrating tablet of inositol nicotinate and a preparation method thereof, which are peripheral vasodilators. For the adjuvant treatment of hyperlipidemia, atherosclerosis and various peripheral vascular disorders. Background technique [0002] Inositol nicotinate is a mild peripheral vasodilator, which is gradually hydrolyzed into niacin and inositol in the body, so it has the pharmacological effects of both niacin and inositol, including lipid-lowering effect. Compared with niacin, its vasodilatory effect is mild and lasting, and there are no adverse reactions such as flushing and stomach discomfort after taking niacin. Inositol nicotinate can selectively dilate blood vessels in lesions and sensitive parts stimulated by cold, while the dilation effect on normal blood vessels is weak. In addition, there are weak thrombolytic, anticoagulant, anti-fatty liv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/38A61K31/455A61P3/06A61P9/10A61P9/14A61P7/02A61P1/16
CPCA61K9/0056A61K9/2095A61K9/2059A61K9/2054A61K31/455A61P3/06A61P9/10A61P9/14A61P7/02A61P1/16
Inventor 董玉娇王宇杰
Owner BEIJING VENTUREPHARM BIOTECH
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