34 results about "Inositol Niacinate" patented technology

An ester formed from an inositol or an inositol derivative and niacin, wherein the inositol or the inositol derivatives comprises a stereoisomer selected from allo-inositol, cis-inositol, epi-inositol, muco-inositol, neo-inositol, scyllo-inositol, D-chiro-inositol and L-chiro-inositol, or pharmaceutically acceptable salts thereof. Examples of esters include inositol hexaniacinates such as allo-inositol hexaniacinate and cis-inositol hexaniacinate. The esters can be used to treat any disorder that is treatable with niacin therapy such as dyslipidemia, hypercholesterolemia, hyperlipidemia or cardiovascular disease. The esters can be administered with other agents such as HMG-CoA reductase inhibitors, statins, fibrates, activators of peroxisome proliferator activated receptors policosanol, phytosterols, tocotrienols, calcium, bile acid sequestrants, guar gum and free niacin. The invention includes pharmaceutical compositions containing these compounds.

The invention discloses a wide-adaptability plant tissue culture medium and 1 / 2 culture medium, each 1000mL culture medium contains: KNO 3 2662mg, (NH 4 ) 2 SO 4 264mg, NH 4 h 2 PO 4 288mg, MgSO 4 ·7H 2 O 370mg, CaCl 2 332mg, MnSO 4 ·H 2 O 15mg, ZnSO 4 ·7H 2 O 4mg, H 3 BO 3 3mg, CoCl 2 ·6H 2 O 0.02mg, CuSO 4 ·5H 2 O 0.04mg, Na 2 MoO 4 2H 2 O 0.1mg, NaFeEDTA 37mg, inositol 100mg, niacin 2mg, thiamine hydrochloride 7mg, pyridoxine hydrochloride 1mg, glycine 2mg; halve the content of macroelements to obtain 1 / 2CS tissue culture medium. The plant tissue culture medium of the present invention can be widely used in various plant tissue cultures, the culture effect is equivalent to or better than MS medium, and it removes the existing There are explosive reagents NH contained in the culture medium 4 NO 3 , which is convenient for the purchase, storage and management of the medium; and the pH stability of the liquid medium prepared with it is good.

The invention discloses a high-frequency differentiation medium of Caoyulu callus, which is composed of inorganic salt, organic components, carbon source, additives, coagulant and hormone, wherein the inorganic salt contains NH 4 NO 3 , KNO 3 , CaCl 2 , KH 2 PO 4 , MgSO 4 , KI, etc., the organic components contain Na 2 EDTA, inositol, niacin, thiamine hydrochloride, pyridoxine hydrochloride and glycine, the carbon source is sucrose, the additive is Caoyulu callus extract, the coagulant is crystal agar, and the hormones are 6‑BA and NAA. The medium can significantly improve the differentiation ability of cells, realize the high-frequency differentiation and regeneration of callus, and form a well-grown grass-gyulu plant under the condition of no root system. There is no need to change the medium type during the entire culture period, which significantly shortens the The time for callus redifferentiation is shortened, and a large number of easy-to-survive tissue culture seedlings are obtained, and the cultivation process is not limited by seasons, which effectively improves the reproduction efficiency and economic benefits.

Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-Kα ray measurement, of the inositol nicotinate crystalline form A has obvious characteristic diffraction peaks at least at 2θ values, expressed in degrees, of 7.05, 7.41, 9.74, 17.80, 19.86, 23.57, 25.48 and 26.20 with an error range of + / −0.2°. The preparation method is one of or a mixed crystallization method of two or more of an evaporation crystallization method, a cooling crystallization method or an anti-solvent crystallization method. The process thereof is simple and easy to operate, and has more selectivity; the inositol nicotinate crystalline form A can be prepared by various methods, and the prepared product has a good crystallization degree and high chemical stability; and the inositol nicotinate crystalline form A prepared by the present method does not have the problem that a residual solvent is out-of-limit.

The invention discloses a production technology of inositol nicotinate, and changes the recovery method of pyridine to alkali ion layering method. By using the principle of like polarity ion effect, the invention employs sodium hydroxide to dissociate salified pyridine, and subjects a mixture of pyridine and water to effective layering, thus achieving the purpose of pyridine recovery. Changing dichlorobenzene extraction method to alkali ion layering method reduces the unit consumption of pyridine by 91.5%, and nonuse of dichlorobenzene any more reduces dichlorobenzene consumption to zero, thus effectively reducing production cost, realizing energy saving, emission lowering and consumption reduction, as well as ecological environment protection.

The invention discloses a preparation method of a special tissue culture solution for Dendrobium officinale, comprising: dissolving potassium iodide, manganese sulfate, zinc sulfate, boric acid, sodium molybdate, copper sulfate and cobalt chloride to obtain a first component; dissolving ferrous sulfate dissolving with disodium EDTA to obtain the second component; dissolving inositol, niacin, pyridoxine hydrochloride, thiamine hydrochloride and glycine to obtain the third component; weighing the peeled potatoes and adding them to the food processor , stir to obtain mashed potatoes, then add coconut water, and mix evenly to obtain material A; add ammonium nitrate, potassium nitrate, calcium chloride, magnesium sulfate, potassium dihydrogen phosphate into water to dissolve to obtain material B; then heat material A, Add material B during the heating process, add the first component, the second component and the third component in turn after stirring evenly, continue to add brown sugar and agar and stir evenly, adjust the pH value to obtain a mixture; Autoclave and cool to room temperature to obtain a special tissue culture solution for Dendrobium officinale.