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Inositol niacinate external use composition and preparation method thereof

A technology of inositol nicotinate and external composition, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as liver function damage and stomach discomfort, and achieve The effect of promoting fat metabolism

Inactive Publication Date: 2018-03-20
广州市桐晖药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have reported that oral inositol nicotinate has the effect of treating acne, but long-term use of inositol nicotinic acid has side effects, such as stomach discomfort, nausea symptoms, and serious damage to liver function

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0069] A preparation method of inositol nicotinate composition for external use, comprising:

[0070] The steps of preparing the oil phase: heat-melt glyceryl stearate, stearic acid, lanolin, white petrolatum, and liquid paraffin, and keep it at 80-85°C as the oil phase;

[0071] The step of preparing the water phase: heating and dissolving ethyl paraben, distilled water, and triethanolamine as the water phase;

[0072] The steps of preparing the composition: mixing the oil phase and the water phase, stirring uniformly, after cooling to 47-52°C, adding inositol nicotinate, tea tree extract, glycolic acid in sequence, and stirring uniformly until condensed.

[0073] As a further solution, the preparation method of the present invention also includes the step of preparing the tea tree extract: selecting fresh tea leaves and fresh shoots, and adding them to CO 2 In the supercritical extractor, water is used as the solvent and ethanol is used as the entrainer. The volume percentage of the ...

Embodiment 1

[0076] A composition for external use of inositol nicotinate comprising the following components in parts by weight:

[0077] 1.0 part of inositol nicotinate,

[0078] 5.0 parts of tea tree extract,

[0079] 3.1 parts of glycolic acid,

[0080] 25 parts of glyceryl stearate,

[0081] 80 parts of stearic acid,

[0082] 8 copies of white petroleum jelly,

[0083] 30 parts lanolin,

[0084] 45 parts of liquid paraffin,

[0085] 3 parts of ethyl paraben,

[0086] 3 parts of triethanolamine,

[0087] 50 parts of distilled water;

[0088] The preparation method includes:

[0089] The steps of tea tree extract: select fresh tea leaves and fresh shoots and add them to CO 2 In the supercritical extractor, water is used as the solvent, ethanol is used as the entrainer, the entrainer accounts for 8% of the total extraction solvent, the extraction pressure is 22MPa, the temperature is 37°C, and CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 3 hours, and the extract is concentrated and d...

Embodiment 2

[0094] A composition for external use of inositol nicotinate comprising the following components in parts by weight:

[0095] 5.0 parts of inositol nicotinate,

[0096] 15.0 parts of tea tree extract,

[0097] 5.5 parts of glycolic acid,

[0098] 40 parts of glyceryl stearate,

[0099] 120 parts of stearic acid,

[0100] 15 parts of white petroleum jelly,

[0101] 60 parts lanolin,

[0102] 65 parts of liquid paraffin,

[0103] 8 parts of ethyl paraben,

[0104] 8 parts of triethanolamine,

[0105] 80 parts of distilled water;

[0106] The preparation method includes:

[0107] The steps of tea tree extract: select fresh tea leaves and fresh shoots and add them to CO 2 In the supercritical extractor, water is used as the solvent and ethanol is used as the entrainer. The volume percentage of the entrainer in the total extraction solvent is 12%. The extraction pressure is 27MPa, the temperature is 46°C, and CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 2 hours, and the extract...

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Abstract

The invention discloses an inositol niacinate external use composition. The inositol niacinate external use composition is prepared from the following ingredients in parts by weight: 1.0 to 5.0 partsof inositol niacinate, 5.0 to 15.0 parts of tea tree extractive, 3.1 to 5.5 parts of glycolic acid, 25 to 40 parts of glyceryl stearate, 80 to 120 parts of stearic acid, 8 to 15 parts of albolene, 30to 60 parts of wool grease, 45 to 65 parts of liquid paraffin, 3 to 8 parts of ethylparaben, 3 to 8 parts of triethanolamine and 50 to 80 parts of distilled water. The invention further discloses a preparation method of the inositol niacinate external use composition. The inositol niacinate external use composition disclosed by the invention is applied to treatment of acne and has a good curing effect and no toxic and side effects at the same time.

Description

Technical field [0001] The invention belongs to the technical field of medicines, and specifically relates to a composition for external use of inositol niacinate and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the hair follicle sebaceous gland unit. It mainly occurs in adolescents and has a great impact on the psychology and social life of adolescents, but it can often be relieved or healed naturally after puberty. The clinical manifestations are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules that occur on the face. The occurrence of acne is closely related to factors such as excessive sebum secretion, clogged hair follicle sebaceous ducts, bacterial infections and inflammatory reactions. . After entering puberty, the level of androgens, especially testosterone, in the human body rises rapidly, which promotes the development of sebaceous glands and produces a large amount of s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K31/444A61K47/18A61K47/06A61K47/44A61K47/14A61K47/12A61P17/10
CPCA61K9/0014A61K31/444A61K36/489A61K36/82A61K47/06A61K47/12A61K47/14A61K47/18A61K47/44A61K2236/37A61K2300/00
Inventor 张彤丽
Owner 广州市桐晖药业有限公司
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