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Application of compound in preparation of antiviral drug and application

A technology of antiviral drugs and compounds, applied in the field of medicine, can solve the problems such as the inability to provide technical support, research reports, and no antiviral drugs for new antiviral clinical candidates, so as to expand the range of options, relieve pulmonary inflammation, and relieve Effects of viral pneumonia

Active Publication Date: 2022-07-12
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been disclosed in the prior art that it has antipyretic, analgesic and anti-inflammatory pharmacological effects, but there is no relevant research report on its anti-virus
[0005] Through the above analysis, the problems and defects of the prior art are: the prior art does not have N-[(2-methoxyphenyl)methyl]-2-[4-(4-methoxyphenyl)- 2-Oxybenzopyran-7-yl]oxyacetamide is theoretically analyzed as a new antiviral clinical candidate drug, but cannot provide technical support for the development of new antiviral clinical candidate drugs

Method used

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  • Application of compound in preparation of antiviral drug and application
  • Application of compound in preparation of antiviral drug and application
  • Application of compound in preparation of antiviral drug and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Compound N-[(2-methoxyphenyl)methyl]-2-[4-(4-methoxyphenyl)-2-oxybenzopyran-7-yl] provided in the examples of the present invention Oxyacetamide, the molecular structure is as follows:

[0032]

[0033] The compound N-[(2-methoxyphenyl)methyl]-2-[4-(4-methoxyphenyl)-2-oxybenzopyran-7-yl]oxyacetamide is in Use in the preparation of anti-coronavirus drugs.

[0034] In the embodiment of the present invention, the compound N-[(2-methoxyphenyl)methyl]-2-[4-(4-methoxyphenyl)-2-oxybenzopyran-7 The dosage of -yl]oxyacetamide is 0.001g / kg / d~0.009g / kg / d.

Embodiment 2

[0036] N-[(2-methoxyphenyl)methyl]-2-[4-(4-methoxyphenyl)-2-oxybenzopyran-7-based on the compound provided in Example 1 of the present invention yl]oxyacetamide uses such as figure 1 As shown, the examples of the present invention provide a compound N-[(2-methoxyphenyl)methyl]-2-[4-(4-methoxyphenyl)-2 for verifying the use -The construction method of the animal model of the efficacy of oxybenzopyran-7-yl]oxyacetamide includes:

[0037] S101, 70 ICR mice, weighing 11±1 g, half male and half male, were randomly divided into normal control group, 229E infection model group, chloroquine phosphate positive drug control group, Lianhua Qingwen positive drug control group, and control group according to body weight. Test compound 0.009g / kg / d dose group, test compound 0.003g / kg / d dose group, test compound 0.001g / kg / d dose group, 10 in each group, half male and half male;

[0038] S102, except for the normal control group, the other groups were infected with HCOV-229E virus liquid, ad...

Embodiment 3

[0040] Based on the construction method of the animal model provided by the embodiment of the present invention, the detection index movement includes:

[0041] Lung index (%) = wet lung weight (g) × 100 / body weight (g);

[0042]

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Abstract

The invention belongs to the technical field of medicines, and discloses application of a compound in preparation of an antiviral drug. The compound N-[(2-methoxyphenyl) methyl]-2-[4-(4-methoxyphenyl)-2-oxybenzopyran-7-yl] oxyacetamide has a new application in medicine, and the application refers to a new application in virus resistance, especially in the aspect of pneumonia caused by coronavirus. The invention proves that the compound has the effects of remarkably inhibiting the lung index and reducing the lung virus load, and the effect of the compound is superior to that of a positive drug chloroquine phosphate and Lanhuaqing pestilence. The action mechanism of the compound for resisting viral pneumonia is related to the aspects of regulating expression of inflammatory factors, regulating differentiation of immune cells, inhibiting generation of free radicals and the like. The N-[(2-methoxyphenyl) methyl]-2-[4-(4-methoxyphenyl)-2-oxybenzopyran-7-yl] oxyacetamide can be used as a safe and effective novel clinical candidate drug for resisting viruses.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the use and application of a compound in the preparation of antiviral drugs. Background technique [0002] Viral pneumonia is caused by the downward spread of upper respiratory tract virus infection. It is closely related to the virulence of the infected virus, the route of infection, the age of the patient, and the immune status. The incidence of children is higher than that of adults, and it is more common in winter and spring. Popular, concentrated outbreak. The clinical manifestations include severe symptoms such as fever, headache, and body aches, and mild local respiratory symptoms, such as cough and expectoration. Coronavirus is one of the main viral pathogens that cause viral pneumonia. There are currently seven coronaviruses that can cause human disease, including three highly pathogenic viruses SARS-CoV, MERS-CoV and SARS-CoV-2 that cause severe respirator...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P31/12A61P31/14A61P11/00
CPCA61K31/37A61P31/12A61P31/14A61P11/00Y02A50/30
Inventor 孙英妮高洪伟
Owner LUDONG UNIVERSITY
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