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Curcumenol bait for mice and preparation method thereof

A technology of alcohol bait and curcumol, which is applied in the field of curcumol bait for mice and its preparation, which can solve the problems of low drug absorption rate and achieve the effects of favorable absorption, long-lasting effect and increased control effect

Active Publication Date: 2022-07-15
YANBIAN TIANBAO BIOLOGICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the drug absorption rate in the above-mentioned technology is low, so it is necessary to further improve the drug absorption

Method used

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  • Curcumenol bait for mice and preparation method thereof
  • Curcumenol bait for mice and preparation method thereof
  • Curcumenol bait for mice and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A curcuma alcohol bait for mice is prepared from the following components by weight: 6 parts of curcuma alcohol, 6 parts of cyclodextrin derivatives, 5 parts of cottonseed powder, 2 parts of fresh milk powder, 2 parts of protein sugar, corn 25 parts of flour, 25 parts of soy flour and 3 parts of ovalbumin.

[0018] Wherein, the preparation method of the cyclodextrin derivative is as follows: adding 12 parts by weight of β-cyclodextrin to 15 parts by weight of ethylenediamine, adding 4 parts by weight of tetrabutyl titanate under stirring, and adding 12 parts by weight to it Phosphoric acid was added several times in small amounts, the temperature was raised to 90 °C, the temperature was kept at 90 °C, and the reaction was carried out under constant temperature conditions for 6 h. After the reaction was completed, vacuum distillation was performed to obtain an oily substance, which is a cyclodextrin derivative. The reaction process as follows:

[0019]

[0020] A pre...

Embodiment 2

[0026] Compared with Example 1, this example has different proportions of raw materials, different preparation conditions of cyclodextrin derivatives, and different preparation conditions of curcumitol bait for mice, and other conditions remain unchanged, specifically:

[0027] A curcuma alcohol bait for mice is prepared from the following components by weight: 12 parts of curcuma alcohol, 12 parts of cyclodextrin derivatives, 10 parts of cottonseed powder, 6 parts of fresh milk powder, 4 parts of protein sugar, corn 30 servings of flour, 35 servings of soy flour and 8 servings of ovalbumin.

[0028] Wherein, the preparation method of the cyclodextrin derivative is as follows: adding 18 parts by weight of β-cyclodextrin to 20 parts by weight of ethylenediamine, adding 6 parts by weight of tetrabutyl titanate under stirring, and adding 16 parts by weight to it Phosphoric acid was added several times in small amounts, the temperature was raised to 110°C, the temperature was kept...

Embodiment 3

[0035] Compared with Example 1, this example has different proportions of raw materials, different preparation conditions of cyclodextrin derivatives, and different preparation conditions of curcumitol bait for mice, and other conditions remain unchanged, specifically:

[0036] A curcuma alcohol bait for mice is prepared by weight of the following components: 9 parts of curcuma alcohol, 10 parts of cyclodextrin derivatives, 8 parts of cottonseed powder, 4 parts of fresh milk powder, 3 parts of protein sugar, corn 28 servings of flour, 30 servings of soy flour and 5 servings of ovalbumin.

[0037] Wherein, the preparation method of the cyclodextrin derivative is as follows: adding 16 parts by weight of β-cyclodextrin to 18 parts by weight of ethylenediamine, adding 4 parts by weight of tetrabutyl titanate under stirring, and adding 14 parts by weight to it Phosphoric acid was added several times in small amounts, the temperature was raised to 100°C, the temperature was kept at ...

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Abstract

The invention relates to the field of medicines, in particular to curcumenol bait for mice and a preparation method thereof, and the curcumenol bait comprises the following components: curcumenol, a cyclodextrin derivative, cottonseed meal, fresh milk powder, protein sugar, corn flour, soybean flour and ovalbumin. Beta-cyclodextrin and phosphoric acid are subjected to an esterification reaction, and a phosphate ester group is successfully introduced into beta-cyclodextrin to form a cyclodextrin derivative, so that the prepared cyclodextrin derivative has relatively good compatibility with a phospholipid bimolecular layer of a cell membrane; and the control effect of the medicament on the population density is increased as time goes on, and the lasting effect of the medicament is relatively long.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a mouse curcuma bait and a preparation method thereof. Background technique [0002] Rats are small rodents with the characteristics of strong adaptability, short sexual cycle and fast reproduction rate. They destroy farmland food, forest trees, grasslands and pastures; cause huge economic losses, and require large amounts of funding from the state's finances for rodent control every year. [0003] The traditional method of killing rodents is to use chemical rodenticides to kill individual rodents. Although the number of rodents will drop rapidly in a short period of time, it will quickly increase again. Zoologists at home and abroad have verified that "the remaining rats will quickly pair and breed, and the number will quickly rebound; if 90 of 100 rats are poisoned to death, the remaining 10 can be quickly re-paired, because the site and food are freed up. , the rest reproduce faster....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/10A01N25/00A01P11/00C08B37/16
CPCA01N43/90A01N25/10A01N25/004C08B37/0015C08B37/0012Y02P60/87
Inventor 赵日良郭俊平
Owner YANBIAN TIANBAO BIOLOGICS