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Compound preparation prepared from cefixime and cimetidine and preparation method
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A compound preparation, the technology of cimetidine, applied in the field of medicine, can solve the problems of insufficient curative effect, troublesome application and the like, and achieve the effects of improving curative effect, safe and convenient use, and delaying metabolism
Inactive Publication Date: 2022-07-15
崔光华
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[0003] In view of the insufficient curative effect of the existing single drug and the troublesome combined application of multiple drugs, the purpose of this application is to provide a compound preparation prepared by cefixime and cimetidine and its preparation method
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Embodiment 1
[0021] A compound preparation prepared from cefixime and cimetidine. Among the active ingredients of the compound preparation, the weight ratio of cefixime and cimetidine is 0.05:0.05, and the balance is auxiliary materials. Its preparation method comprises the following steps:
[0022] (1) Get 5g of cefixime crude drug for standby;
[0023] (2) get 5g of cimetidine crude drug for subsequent use;
[0024] (3) Get an appropriate amount of the auxiliary materials required for preparing it into granules, and reserve it for later use;
[0025] (4) Prepare granules according to the preparation method of pharmaceutical granules, so that each contains 50 mg of cefixime and 50 mg of cimetidine.
Embodiment 2
[0027] A compound preparation prepared from cefixime and cimetidine. Among the active ingredients of the compound preparation, the weight ratio of cefixime and cimetidine is 0.10:0.20, and the balance is auxiliary materials. Its preparation method comprises the following steps:
[0028] (1) Take 10g of cefixime raw material drug, spare
[0029] (2) Take 20g of cimetidine original drug, spare
[0030] (3) get an appropriate amount of auxiliary materials required to prepare it into capsules, for subsequent use;
[0031] (4) Capsules are made according to the preparation method of pharmaceutical capsules, so that each capsule contains 100 mg of cefixime and 200 mg of cimetidine.
Embodiment 3
[0033] A compound preparation prepared from cefixime and cimetidine. Among the active ingredients of the compound preparation, the weight ratio of cefixime and cimetidine is 0.10:0.30, and the balance is auxiliary materials. Its preparation method comprises the following steps:
[0034] (1) Take 10g of cefixime raw material drug, spare
[0035] (2) Take 30g of cimetidine original drug, spare
[0036] (3) Get an appropriate amount of auxiliary materials required to prepare it into a tablet, and reserve it for later use;
[0037] (4) Prepare tablets according to the pharmaceutical tablet preparation method, so that each tablet contains 100 mg of cefixime and 300 mg of cimetidine.
[0040] 1. Select the medicines prepared in Examples 1, 2, and 3 to conduct clinical trials.
[0041] According to the parallel, random and controlled experimental design scheme, a control group was strictly set up to observe th...
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Abstract
The invention provides a compound preparation prepared from cefixime and cimetidine and a preparation method of the compound preparation, and the compound preparation comprises the active ingredients of cefixime and cimetidine in a ratio of (0.05-0.10): (0.05-0.40). The cefixime and cimetidine are taken as active pharmaceutical ingredients, then a proper amount of auxiliary materials required by the prepared preparation form are taken, and compound preparations such as tablets, capsules, injections, dry suspensions or granules and the like can be prepared according to corresponding preparation preparation methods in pharmaceutics respectively. In the invention, cefixime achieves a bactericidal effect by inhibiting synthesis of cell walls in a bacterial reproduction period. Cimetidine is an H2 receptorantagonist and a liver drugenzyme inhibitor and can delaymetabolism of cefixime and improve the blood concentration of cefixime so as to improve the curative effect; moreover, the irritation of cefixime to the stomach can be relieved by inhibiting gastric acidsecretion. The two components are combined and proportioned according to a proper dosage to prepare a compound preparation, so that the curative effect of the cefixime can be remarkably improved, and the side effect of the cefixime can be reduced.
Description
technical field [0001] The application relates to the technical field of medicine, and in particular to a compound preparation prepared from cefixime and cimetidine and a preparation method. Background technique [0002] Cefixime is a semi-synthetic third-generation cephalosporin antibiotic with a broad antibacterial spectrum, against Streptococcus pyogenes, Streptococcus pneumococcus, Streptococcus agalactiae, Neisseria gonorrhoeae, Influenza bacillus, Moraxella and Escherichia coli, Pneumococcus and other bacteria have good antibacterial activity. It is suitable for the treatment of bronchitis, pneumonia, pyelonephritis, cystitis, urethritis, cholecystitis, cholangitis, scarlet fever, otitis media, sinusitis and other diseases. However, with the wide application of cefixime in clinical practice, drug-resistant bacterial beads have gradually emerged, and the efficacy has declined. When taking orally, side effects such as gastrointestinal diarrhea, abdominal pain, loss of ...
Claims
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Application Information
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