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Microneedle and manufacturing process thereof

A manufacturing process and microneedle technology, which can be applied to other medical devices, drug devices and other directions, can solve the problems of difficulty in large-scale popularization, time-consuming, high preparation cost, and achieve long-term stable transdermal administration and simple preparation process. , mature and stable effect

Pending Publication Date: 2022-07-15
杭州恒升医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Hollow microneedles have the advantage of large drug loading due to their hollow structure. However, they usually need to be processed and prepared by digitally controlled micro-electromechanical systems. The entire preparation process is precise and complicated, and the preparation cost is high and time-consuming. It is difficult to promote and use on a large scale. waiting to be solved

Method used

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  • Microneedle and manufacturing process thereof
  • Microneedle and manufacturing process thereof
  • Microneedle and manufacturing process thereof

Examples

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Effect test

Embodiment 1

[0035] see figure 1 , a manufacturing process of a microneedle of the present invention comprises the following steps:

[0036] a) Opening: Select a substrate 1 with an appropriate thickness as required, and then etch several concave portions 11 on the top surface of the substrate 1 that do not penetrate the bottom surface. The substrate 1 is a glass substrate, and each of the concave portions 11 are all inverted cones, and each of the inner recesses 11 is etched by maskless etching technology;

[0037] Among them, the maskless etching technology can be a laser etching technology, which can irradiate the top surface of the substrate 1 with a high-energy-density laser, so that the surface material of the irradiated area is subjected to heat, melting, vaporization, plasma formation, volatilization and sputtering. A series of complex physical and even chemical processes such as radiation, etc., finally form the inner recess 11;

[0038] b) Film formation: the needle body membra...

Embodiment 2

[0044] see figure 2 , a manufacturing process of a microneedle of the present invention comprises the following steps:

[0045] a) Opening: Select a substrate 1 with an appropriate thickness as required, and then etch several concave portions 11 on the top surface of the substrate 1 that do not penetrate the bottom surface. The substrate 1 is a glass substrate, and each of the concave portions 11 are all inverted cones, and each of the inner recesses 11 is etched by photoresist etching technology;

[0046] Among them, the photoresist etching technique is specifically as follows: first, a photoresist is coated on the top surface of the substrate 1 to form a photoresist layer 3 , and after drying, a mask is used to block the photoresist layer 3 , so that the light irradiates the photoresist layer 3 . In some areas, the exposed or unexposed areas of the photoresist layer 3 are dissolved by the developer to form the through holes 31 , and finally the plasma generated under the a...

Embodiment 3

[0053] see image 3 , a manufacturing process of a microneedle of the present invention comprises the following steps:

[0054]a) Opening: Select a substrate 1 with an appropriate thickness according to the needs, and then etch several recesses 11 on the top surface of the substrate 1 that do not penetrate the bottom surface. The substrate 1 is a glass substrate, and each of the recesses 11 are all inverted cones, and each of the inner recesses 11 is etched by maskless etching technology;

[0055] Among them, the maskless etching technology can be a laser etching technology, which can irradiate the top surface of the substrate 1 with a high-energy-density laser, so that the surface material of the irradiated area is subjected to heat, melting, vaporization, plasma formation, volatilization and sputtering. A series of complex physical and even chemical processes such as radiation, etc., finally form the inner recess 11;

[0056] b) Film formation: the needle body film layer 2...

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Abstract

The invention discloses a microneedle and a manufacturing process thereof. The manufacturing process of the microneedle comprises the following steps: a) opening: etching a plurality of inner concave parts on the top surface of a substrate; b) forming a film: generating a needle body film layer on the top surface of the substrate, and meanwhile, enabling a part of the needle body film layer to sink into each concave part and respectively form a hollow sinking structure or a solid sinking structure; c) trepanning: when the hollow sinking structures are formed, polishing the bottom surface of the substrate until the bottom of each hollow sinking structure is upwards worn through and a hollow channel is formed; when the solid sinking structures are formed, etching the top surfaces of the solid sinking structures until the top surfaces penetrate through the bottom surface of the substrate and hollow channels are formed; and d) removing the substrate: removing the substrate. According to the preparation method, the single microneedle or microneedle array with a micron-sized mechanical channel can be prepared, the whole preparation process is simple, mature and stable, and the preparation cost is low.

Description

【Technical field】 [0001] The present invention relates to the technical field of medical equipment, in particular to the technical field of a microneedle and a manufacturing process thereof. 【Background technique】 [0002] Microneedles (MN) is a new type of physical penetration technology, which consists of multiple micron-sized needle tips connected to the base in an array, which can be directed through the stratum corneum to generate micron-sized mechanical channels. The drug is directly placed in the epidermis or upper dermis, and it can participate in the microcirculation without passing through the stratum corneum, and exert a pharmacological reaction. [0003] According to the characteristics of microneedles, microneedles can be divided into solid microneedles, hollow microneedles, coated microneedles, soluble microneedles and hydrogel microneedles. Among them, the hollow microneedles (Hollow microneedles), namely the hollow microneedles, are essentially micron-level ...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023A61M2037/0053
Inventor 王元武王金强乔伟刘涛顾臻乔建民
Owner 杭州恒升医学科技有限公司
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