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Preparation method of crocin double-layer coated micro-capsule

A double-layer technology of saffron and glycosides is applied in the field of preparation of double-layer encapsulated microcapsules of saffron, and can solve the problems of short stabilization time, low encapsulation rate, inapplicability of saffron and the like

Active Publication Date: 2022-07-29
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, other carotenoid compounds are oil-soluble, while crocin is water-soluble. The existing method of embedding carotenoids is not suitable for crocin. Anthocyanin will have technical problems such as low encapsulation efficiency and short stability time

Method used

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  • Preparation method of crocin double-layer coated micro-capsule
  • Preparation method of crocin double-layer coated micro-capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: a kind of preparation method of crocin double-layer encapsulation microcapsule, adopts the following steps:

[0029] A. Weigh 10% crocin, 0.1% metal chelating agent, 0.1% Tremella polysaccharide, 0.1% co-coloring agent, 2% emulsifier, 2% high molecular polymer, 2% emulsifier according to the following mass percentages Oil, the balance is water; the metal chelating agent is disodium EDTA, the co-coloring agent is ascorbic acid; the emulsifier is Span series emulsifier; the high molecular polymer is hydrogenated (styrene / methylbenzene) Ethylene / indene) copolymer; Described grease is a mixture of cyclic silicone oil and isododecane;

[0030] B, the crocin, metal chelating agent, Tremella polysaccharide, co-coloring agent taken by step A are mixed and added to the water taken by step A, stirred and used as water phase;

[0031] C, the emulsifier, macromolecular polymer, oil and fat taken by step A are mixed and evenly stirred and used as oil phase;

[0032] ...

Embodiment 2

[0036] Embodiment 2: a kind of preparation method of crocin double-layer encapsulated microcapsule, adopts the following steps:

[0037]A. Weigh 40% crocin, 1% metal chelating agent, 1% Tremella polysaccharide, 1% co-coloring agent, 10% emulsifier, 5% high molecular polymer, 15% by the following mass percentages Oil, the balance is water; the metal chelating agent is magnesium sulfate, and the co-coloring agent is tea polyphenol; the emulsifier is Span series emulsifier; the high molecular polymer is diisostearoyl polyglycerol -3 dimerized linoleate; described grease is isohexadecane;

[0038] B, the crocin, metal chelating agent, Tremella polysaccharide, co-coloring agent taken by step A are mixed and added to the water taken by step A, stirred and used as water phase;

[0039] C, the emulsifier, macromolecular polymer, oil and fat taken by step A are mixed and evenly stirred and used as oil phase;

[0040] D, adding the water phase gained in step B and the oil phase gained...

Embodiment 3

[0044] Embodiment 3: a kind of preparation method of crocin double-layer encapsulation microcapsule, adopts following steps:

[0045] A. Weigh 25% crocin, 0.5% metal chelating agent, 0.5% Tremella polysaccharide, 0.5% co-coloring agent, 6% emulsifier, 3% high molecular polymer, 10% emulsifier according to the following mass percentages Oil, the balance is water; the metal chelating agent is disodium EDTA, the co-coloring agent is a mixture of ascorbic acid, tea polyphenols, and glutathione; the emulsifier is a Span series emulsifier; the high The molecular polymer is a mixture of hydrogenated (styrene / methylstyrene / indene) copolymer, diisostearoyl polyglycerol-3 dimerized linoleate, and dextrin isostearate; the oil is A mixture of cyclic silicone oil, isododecane, and isohexadecane;

[0046] B, the crocin, metal chelating agent, Tremella polysaccharide, co-coloring agent taken by step A are mixed and added to the water taken by step A, stirred and used as water phase;

[004...

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Abstract

The invention relates to a preparation method of crocin double-layer coated microcapsules, which is characterized by comprising the following steps: A, weighing crocin, a metal chelating agent, tremella polysaccharide, an auxiliary color agent, an emulsifier, a high-molecular polymer, grease and the balance of water according to a mass ratio; b, crocin, a metal chelating agent, tremella polysaccharide and an auxiliary color agent are mixed and then added into water, and the mixture is stirred to be uniform to serve as a water phase; c, mixing and uniformly stirring an emulsifier, a high-molecular polymer and grease to serve as an oil phase; d, adding the water phase and the oil phase into a high-pressure homogenizer, and homogenizing to obtain crocin single-layer coated microemulsion; e, preparing an external water phase; f, coating the crocin single-layer coated micro-emulsion and an outer water phase, and adding the crocin single-layer coated micro-emulsion into the outer water phase through an SPG membrane emulsification method to obtain a micro-capsule suspension; and G, carrying out spray drying on the microcapsule suspension to obtain the crocin double-layer coated microcapsule. The product disclosed by the invention has the advantages that crocin is not easy to fade and good in stability.

Description

technical field [0001] The invention relates to the technical field of sustained-release microcapsules, in particular to a preparation method of double-layer-wrapped microcapsules of crocin. Background technique [0002] Crocin is the only water-soluble carotenoid compound that exists in nature, widely exists in saffron, also known as crocin or crocin. At present, it is mainly used as a natural colorant in the food, dye, and cosmetic industries. Crocin is a series of ester glycosides composed of crocus acid and different sugars, mainly including crocin I, crocin II, crocin III, crocin IV, etc. The content of safflower I was the highest, accounting for about 70% to 80%. Crocin is easily soluble in water to form a transparent yellow solution, soluble in ethanol and propylene ester, but insoluble in oil. In the current industry, crocin is often directly added to the product, but the stability of crocin is poor, and it will cause inactivation and fading when exposed to heat, ...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/73A61K8/44A61K8/19A61K8/67A61K8/64A61K8/86A61K8/81A61K8/58A61K8/34A61K8/49A61K8/02A61Q19/00A23L5/44A23L29/00A23L29/30A23P10/30A23P10/35
CPCA61K8/602A61K8/73A61K8/732A61K8/44A61K8/19A61K8/676A61K8/498A61K8/64A61K8/86A61K8/8117A61K8/585A61K8/34A61K8/4973A61K8/0262A61Q19/00A23L5/44A23L29/045A23L29/015A23L29/035A23L29/055A23L29/30A23L29/04A23P10/30A23P10/35A61K2800/43A61K2800/51A61K2800/624A61K2800/63A61K2800/805A61K2800/10A23V2002/00A23V2200/04A23V2250/211A23V2250/51A23V2200/222A23V2250/18A23V2250/1614A23V2250/708A23V2300/10A23V2250/161A23V2250/2132A23V2250/214A23V2250/55Y02W90/10
Inventor 韩丹杨盼盼吕旭阳陈金龙孙静霞孙淑蓉
Owner PROYA COSMETICS
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