Preparation method of spray type bi-component composite Raman substrate
A Raman-based, two-component technology, applied in Raman scattering, injection devices, material excitation analysis, etc., can solve the problems of low production efficiency, incapable of large-scale production, complicated operation, etc., and is suitable for large-scale production and not easy to agglomerate , to avoid the effect of interference
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[0028] A preparation method of a spray-type two-component composite surface-enhanced Raman substrate, comprising the following steps:
[0029] Step 1. Disperse the centrifuged gold nanorods in deionized water to obtain solution A, and the concentration of gold nanorods in solution A is 0.3-0.5 g / mL;
[0030] Step 2. Dispersing the silica dielectric microspheres in a mixed solution of ethanol and ethylene glycol to obtain a solution B, the concentration of the silica dielectric microspheres in the solution B is 0.025-0.05 g / mL;
[0031] Step 3. Heat the substrate to 80-110°C, then mix solution A and solution B evenly, and then spray evenly on the surface of the heated substrate, the spray diameter is 0.3mm-0.5mm, the spraying time is 10min-30min, and the spraying ends Then, the heating of the substrate is stopped, and after natural cooling, an enhanced Raman base can be obtained on the surface of the substrate.
Embodiment 1
[0033] A preparation method of a spray-type two-component composite surface-enhanced Raman substrate, comprising the following steps:
[0034] Step 1. Use the seed solution growth method to synthesize the gold nanorod solution with an aspect ratio of 3. The specific process is:
[0035] Step 1.1. Preparation of gold nanorod seed solution: at 25°C, add 0.5 mL of 0.5 mmol / L chloroauric acid solution to 7.5 mL of 0.1 mol / L CTAB solution, and the solution changes from transparent to light yellow; then Add 0.8 mL of 0.01M sodium borohydride solution in ice bath, the solution turns brown; store at 25°C for two hours to obtain the seed solution of gold nanorods;
[0036] Step 1.2. Preparation of gold nanorod growth solution: at 25 °C, add 0.8 mL of 0.5 mmol / L chloroauric acid solution to 9.5 mL of 0.1 mol / L CTAB solution, and the solution changes from transparent to light yellow; then sequentially Add 60 μL of silver nitrate solution with a concentration of 0.01 mol / L and 64 μL of 0...
Embodiment 2
[0045] In order to explore the practicality of the device, the hybrid substrate was selected for the detection of 3,4-methylenedioxymethamphetamine (MDMA). MDMA solutions with concentrations of 10 nM, 100 nM, 1 μM, 10 μM and 100 μM were prepared, respectively, in which ethanol was the solvent. After making the substrate, soak the substrate in the corresponding solvent, rinse the soaked substrate with ethanol after half an hour, and perform the SERS test after natural drying. For the accuracy of the results, 5 different places are selected for signal acquisition in the corresponding regions of the SERS substrate, and the Raman spectra of the present invention are the average levels of the Raman spectra of the SERS substrates in different regions.
[0046] The SERS spectrum obtained by the test in this example is as follows Figure 5 shown. It can be seen from the figure that the detection limit of the Raman-enhanced substrate of the present invention for MDMA can reach 10 nM....
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