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Triple antibiotic phase change gel capable of being rapidly removed, preparation method and application

A technology of antibiotics and gels, applied in the field of stomatology, can solve the problems of incomplete dissolution of drugs, lack of sustained release effect, poor disinfection effect, etc., to retain disinfection ability, prolong the effect of drugs, and improve clinical operability Effect

Active Publication Date: 2022-08-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the above analysis, the existing problems and defects of the existing technology are: the existing drugs cannot be completely dissolved, there are residues, the disinfection effect is not good, and there is no sustained release effect, certain toxicity, and low safety

Method used

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  • Triple antibiotic phase change gel capable of being rapidly removed, preparation method and application
  • Triple antibiotic phase change gel capable of being rapidly removed, preparation method and application
  • Triple antibiotic phase change gel capable of being rapidly removed, preparation method and application

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preparation example Construction

[0066] like figure 1 As shown, the preparation method of the rapidly removable triple antibiotic phase change gel provided by the embodiment of the present invention includes:

[0067] S101, respectively carry out sodium alginate solution, CaSO 4 Suspension, Na 2 HPO 4 Preparation of solution and TAP;

[0068] S102, based on formulated sodium alginate solution, CaSO 4 Suspension, Na 2 HPO 4 Solution, TAP Preparation TAP is ALG-TAP hydrogel with different concentrations.

[0069] The embodiment of the present invention provides sodium alginate solution, CaSO 4 Suspension, Na 2 HPO 4 The preparation of solution, TAP includes:

[0070] Preparation of sodium alginate solution: take a certain amount of sodium alginate and dissolve it in 50 times the amount of ddH 2 O, stirred overnight to obtain a sodium alginate solution with a concentration of 2%, filtered under sterile conditions using a 0.22 μm filter, and stored at 4°C;

[0071] Formulation of CaSO 4 Suspension: t...

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Abstract

The invention belongs to the technical field of oral medicine, and discloses triple antibiotic phase change gel capable of being rapidly removed, and a preparation method and application thereof, and the preparation method comprises the following steps: respectively preparing a sodium alginate solution, a CaSO4 suspension, a Na2HPO4 solution and TAP; based on the prepared sodium alginate solution, CaSO4 suspension, Na2HPO4 solution and TAP, the ALG-TAP hydrogel with different concentrations of TAP is prepared. According to the invention, the technical prejudice caused by the fact that triple antibiotics are directly blended into paste and then placed into a root canal is overcome, sodium alginate is used as a carrier, the toxicity of direct paste implantation is reduced, the drug action effect is prolonged, drug residues are reduced, and the clinical operability, the treatment success and the patient comfort are improved. The triple antibiotic phase change gel capable of being quickly removed can be used for disinfecting root canals in the dental pulp regeneration process, has the phase change characteristic, and is easier to quickly and thoroughly remove after being disinfected.

Description

technical field [0001] The invention belongs to the technical field of stomatology, in particular to a triple antibiotic phase change gel that can be quickly removed, a preparation method and an application. Background technique [0002] At present, young permanent teeth are easily affected by factors such as caries and developmental deformities during the development process, resulting in pulpitis and apical periodontitis, resulting in stagnant root development, thick apical foramen, and thin root bone wall, which reduces oral health. quality and longevity of teeth. Regenerative endodontic treatment is the current cutting-edge treatment method and has achieved considerable therapeutic effects. Infection control is critical in regenerative endodontic treatment. The traditional root canal disinfectant calcium hydroxide relies on strong alkaline sterilization, but its high pH cannot be maintained in the dentinal tubules, and the bacterial killing effect is poor. The emergin...

Claims

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Application Information

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IPC IPC(8): A61K6/52
CPCA61K6/52Y02A50/30
Inventor 叶玲孙一民汪成林陈霞
Owner SICHUAN UNIV
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