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Vaginal effervescence tablet composition containing solid lipid

An effervescent tablet and composition technology, which is applied in the field of vaginal effervescent tablet compositions containing solid lipids, can solve the problem that the adhesion of effervescent tablets affects drug distribution, the gelatinous substances are difficult to be cleaned, the drug distribution is uneven, etc. problem, to achieve the effect of low viscosity, prolonged effect and easy removal

Inactive Publication Date: 2010-01-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the formation of thick jelly will make the effervescent tablet have strong adhesion and affect the distribution of the drug to the vaginal wall, resulting in uneven distribution of the drug on the vaginal mucous membrane; on the other hand, the jelly is difficult to remove clean, affecting patient hygiene

Method used

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  • Vaginal effervescence tablet composition containing solid lipid
  • Vaginal effervescence tablet composition containing solid lipid
  • Vaginal effervescence tablet composition containing solid lipid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Formula of Nystatin Vaginal Effervescent Tablet 1

[0103]

[0104]

[0105] Preparation method: mix nystatin, part of lactose, and di-tert-butyl-p-cresol, use absolute ethanol solution to make soft material, pass through 60 mesh to make wet granules, dry at 30°C for 60 minutes, and pass through 60 mesh for granulation , add sodium lauryl sulfate, sodium bicarbonate, tartaric acid, Compritol 888 ATO, magnesium stearate and remaining lactose are mixed evenly and compressed into diamond-shaped tablets. The hardness of gained tablet is controlled at 10-12kg / mm 2 .

[0106] The nystatin vaginal effervescent tablet that adopts embodiment 1 to prepare carries out quality research, and the results are as follows:

[0107] project

Embodiment 2

[0109] Formulation of Secnidazole Vaginal Effervescent Tablet 2

[0110]

[0111] Preparation method: Secnidazole, Precirol ATO 5, lactose, sodium bicarbonate, citric acid, sodium lauryl sulfate and magnesium stearate were mixed in a container for 25 minutes, then transferred to a tablet machine and compressed into diamond-shaped tablets. The hardness of gained tablet is controlled at 9-11kg / mm 2 .

[0112] The obtained secnidazole vaginal effervescent tablet that adopts embodiment 2 to prepare carries out quality research, and the results are as follows:

[0113] project

Embodiment 3

[0115] Formulation of Clindamycin Phosphate Vaginal Effervescent Tablet 3

[0116]

[0117] Preparation method: Clindamycin phosphate, Compritol 888 ATO, part of lactose, tartaric acid, and sodium lauryl sulfate were mixed in a container for 25 minutes, and an appropriate amount of 5% povidone K30 aqueous solution was added to prepare a soft material, granulated through a 40-mesh sieve, and air-dried at 50 degrees for 45 minutes , after taking out, pass through a 40-mesh sieve to obtain granule I. In addition, put sodium bicarbonate and part of lactose in a container and mix for 25 minutes, add an appropriate amount of 5% povidone K30 aqueous solution to prepare a soft material, pass through a 40-mesh sieve to granulate, blow dry at 50 degrees for 45 minutes, take it out and pass through a 40-mesh Sieve to obtain Granule II. Mix granules I and II, add magnesium stearate and mix for 10 minutes, then transfer to a tablet machine and compress into diamond-shaped tablets. T...

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Abstract

The invention provides a vaginal effervescent tablet composition that comprises 100 weight portions of active drug ingredients and 20-1000 weight portions of solid lipid. The vaginal effervescent tablet composition of the invention can be released in vagina slowly and continuously, ensuring that the sufferer feels comfortable, and generates foams that can ensure fine drug powder to be uniformly distributed, leading the drug to be uniformly distributed in the inner wall mucosa of the vagina; meanwhile, the foams last for a long time, which prolongs dramatically the even contact time of the drug and the mucosa of the vagina and extends the effect of the drug; furthermore, the vaginal effervescent tablet composition is easily washed out and more beneficial to the health of sufferers.

Description

technical field [0001] The invention relates to a vaginal effervescent tablet composition, in particular to a vaginal effervescent tablet composition containing solid lipid. Background technique [0002] Vaginal effervescent tablet is a kind of effervescent tablet administered intravaginally. The prescription contains an acid-base pair composed of acidic compounds and basic compounds as an effervescent disintegrant. It can absorb water, foam and disintegrate when it meets secretions in the vagina. Decomposition produces foam (carbon dioxide gas), and the fine powder of the drug is distributed in the foam to contact and absorb the vaginal mucosa. Vaginal effervescent tablets have now become an effective dosage form for the treatment of gynecological diseases. [0003] Many drugs are suitable for clinical use in the form of vaginal effervescent tablets for the treatment of various gynecological diseases, including: trichomonas, fungal, gonococcal infection and other vaginitis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K47/14A61K47/20A61K47/34A61K31/18A61K31/4164A61K31/7048A61K31/7056A61P15/02
Inventor 张建军高缘
Owner CHINA PHARM UNIV
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