Composition for resisting fatigue, enhancing immunity and treating rheumatism and preparation method thereof

An immunotherapy and anti-fatigue technology, which can be used in drug combinations, resistance to vector-borne diseases, and medical preparations containing active ingredients, etc. Achieve improved dissolution rate and transfer rate, treatment of rheumatoid arthritis, less irritation and less side effects

Pending Publication Date: 2022-08-09
NINGBO YUFANGTANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are three main treatment methods for rheumatoid arthritis: the first is drug treatment. At present, most of the best-selling RA drugs in Europe, America, Japan and South Korea are non-steroidal anti-inflammatory drugs, antirheumatic drugs, glucocorticoids, and biological agents. Immunosuppressants, etc. These substances can only temporarily relieve inflammation and have no definite effect on joint damage. They treat the symptoms but not the root cause, and long-term use of anti-inflammatory drugs will increase the potential risk of increased drug tolerance and affect the normal physiological functions of the human body
The second is functional exercise. Exercise is an important method for patients with rheumatoid arthritis to restore and maintain joint function. However, improper exercise methods and methods will aggravate the intrusion of inflammation and must be carried out under the guidance of professional doctors.
The third is the traditional surgical treatment. This method has problems such as long incision, heavy bleeding, heavy trauma, high cost and easy recurrence.

Method used

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  • Composition for resisting fatigue, enhancing immunity and treating rheumatism and preparation method thereof
  • Composition for resisting fatigue, enhancing immunity and treating rheumatism and preparation method thereof
  • Composition for resisting fatigue, enhancing immunity and treating rheumatism and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Example 1: Preparation of the composition for anti-fatigue and immunotherapy for rheumatism

[0072] 1.1 Preparation of Cistanche Extract or Cornus Extract

[0073] The Cistanche deserticola or Cornus officinalis decoction pieces are combined with microwave and ultrasonic extraction, vacuum concentration, vacuum freeze-drying, pulverization and sieving to obtain the required Cistanche deserticola or Cornus officinalis extract. The specific process is as follows:

[0074] (a) Combined extraction with microwave and ultrasonic: Put Cistanche or Cornus decoction pieces in a microwave ultrasonic extraction tank, extract 3 times, 0.5h each time, add water 10 times the amount of medicinal materials, keep the microwave power at 8kw, and the ultrasonic power at 2kw, The extraction temperature was kept at 90°C, filtered, and the extracts were combined;

[0075] (b) vacuum concentration: the above-mentioned extraction solution is concentrated under vacuum, the concentration temp...

experiment example 2

[0114] Experimental Example 2: Evaluation of Functional Tests of Animals to Enhance Immunity

[0115] 2.1 Materials

[0116] The test sample is the composition for anti-fatigue and immunotherapy of rheumatism of the present invention prepared in Example 1.6. The recommended daily dose of the product is 5g, and the recommended dose of the sample is 0.083g / kg.BW based on an adult body weight of 60kg.

[0117] The experiment set up three dose groups and a negative control group (distilled water). The low, medium and high doses were 0.42, 0.83 and 2.50 g / kg of the anti-fatigue and immunotherapy composition for rheumatism, which was equivalent to 5, 10 of the recommended human dose. and 30 times. Before the test, the samples were prepared into various doses with distilled water as the solvent, and mixed well for the test.

[0118] In the three-dose groups, 4.2, 8.3, and 25.0 g of the product fine powder were added to 100 mL of distilled water to prepare samples with concentration...

experiment example 3

[0140] Experimental Example 3: Evaluation of Functional Tests for Relieving Physical Fatigue in Animals

[0141] 3.1 Materials

[0142] The test sample is the anti-fatigue and immune-enhancing rheumatism composition of the present invention trial-produced in Example 1.6. The recommended daily dose of the product is 5g. Based on an adult body weight of 60kg, the recommended sample dose is 0.083g / kg.BW.

[0143] The experiment set up three dose groups and a negative control group (distilled water). The low, medium and high doses were 0.42, 0.83 and 2.50 g / kg of the anti-fatigue and immunotherapy composition for rheumatism, which was equivalent to 5, 10 of the recommended human dose. and 30 times. Before the test, the samples were prepared into various doses with distilled water as the solvent, and mixed well for the test.

[0144] In the three-dose groups, 4.2, 8.3, and 25.0 g of product fine powder were added to 100 mL of distilled water to prepare samples with concentrations...

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Abstract

The invention relates to a composition for resisting fatigue, enhancing immunity and treating rheumatism and a preparation method thereof. The composition is prepared from the following components in parts by mass: 19 to 35 parts of herba cistanche extract, 12 to 26 parts of fructus corni extract, 8 to 18 parts of radix angelicae pubescentis enzymolysis powder, 4 to 12 parts of cortex moutan enzymolysis powder, 14 to 28 parts of compound traditional Chinese medicine fermentation extract and 8 to 16 parts of compound traditional Chinese medicine extract. The traditional Chinese medicine composition has the effects of enhancing immunity, relieving physical fatigue and treating rheumatoid arthritis, the dose-effect relationship of all the components is fully mastered, the extract is prepared through a specific production and preparation technology, the medicine effect and the bioavailability of the medicinal materials are improved, and the preparation method is high in general applicability and suitable for industrial production. The method is suitable for producing and processing various dosage forms such as tablets, hard capsules, soft capsules, granules, oral liquid and the like, is easy to operate, stable in process, controllable in quality, high in production efficiency, high in economic added value and suitable for large-scale and industrial mass production.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a composition for anti-fatigue and immune-enhancing treatment of rheumatism and a preparation method thereof. Background technique [0002] Fatigue is a physiological phenomenon of the human body and a protective mechanism signal sent by the body. If this signal is ignored, the body will be damaged, and eventually it will become ill. Fatigue can be divided into acute fatigue and chronic fatigue according to the way it occurs. Among them, acute fatigue is mainly caused by frequent and intense muscle activity, while chronic fatigue is mainly caused by prolonged and repeated activities. Further, the symptoms of fatigue can be divided into general symptoms and local symptoms. When performing systemic strenuous muscle exercise, in addition to muscle fatigue, respiratory muscle fatigue also occurs, such as increased heart rate, conscious palpitations or dyspnea. Since various activities ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88A61P29/00A61P37/04A61P39/00
CPCA61K36/64A61K36/40A61K36/232A61K36/71A61K36/65A61K36/21A61K36/754A61K36/296A61K36/88A61P39/00A61P37/04A61P29/00A61K2236/19A61K2236/37A61K2236/51A61K2236/331A61K2300/00Y02A50/30
Inventor 雷蕾王彩霞王俊熊菲菲涂宏建陶刚冯煦洸戎宁平贾福怀
Owner NINGBO YUFANGTANG BIOTECH
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