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Responsive slow-release type polydopamine-Zn-natural polyphenol coordination nano-drug and preparation method thereof

A technology of natural polyphenols and polydopamine, which is applied in the direction of nano-drugs, drug combinations, nano-technology, etc., can solve problems such as the stability of natural polyphenols, and achieve the effect of enhancing stability and reducing the rate of deterioration

Active Publication Date: 2022-08-09
YUNNAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, it is worth noting that the above solutions cannot solve the stability of natural polyphenol drugs, and even some central coordination metals will generate highly oxidative hydroxyl radicals through Fenton reaction or Fenton-like reaction to accelerate the stability of natural polyphenol drugs. At the same time, due to the connection of the simple coordination bond, the above system will release the drug once the coordination bond is broken, which has the characteristics of rapid response release. However, the scenes faced by natural polyphenol drugs are mainly such as diabetes, cardiovascular disease, fat For chronic metabolic diseases such as the liver, what is more needed is a drug-loading system with slow response and release, which is also the function that the current coordination self-assembly drug-loading system for natural polyphenol drugs lacks.
At present, there is no report on the response sustained release drug delivery system of natural polyphenol drugs

Method used

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  • Responsive slow-release type polydopamine-Zn-natural polyphenol coordination nano-drug and preparation method thereof
  • Responsive slow-release type polydopamine-Zn-natural polyphenol coordination nano-drug and preparation method thereof
  • Responsive slow-release type polydopamine-Zn-natural polyphenol coordination nano-drug and preparation method thereof

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preparation example Construction

[0031] The invention provides a preparation method of a response slow-release polydopamine-Zn-natural polyphenol coordination nanomedicine, comprising the following steps:

[0032] (1) mixing natural polyphenol drug solution, dopamine solution and Zn ion solution to carry out coordination reaction to obtain coordination precursor solution;

[0033] (2) mixing the coordination precursor solution and the surfactant solution to carry out a self-assembly reaction to obtain self-assembled nanoparticles; the solvent of the surfactant solution is an alkaline buffer;

[0034] (3) mixing the self-assembled nanoparticles with an alkaline buffer to carry out a dopamine polymerization reaction to obtain a response slow-release polydopamine-Zn-natural polyphenol coordination nanomedicine.

[0035]In the present invention, the natural polyphenol drug solution, the dopamine solution and the Zn ion solution are mixed to carry out a coordination reaction to obtain a coordination precursor solu...

Embodiment 1

[0047] (1) Preparation of dopamine-Zn-astragalin (BAI) coordination precursor solution: First, astragalin, dopamine and ZnCl were mixed 2 Dissolved in DMSO, respectively, to obtain 5 mg / mL astragalin solution, 10 mg / mL dopamine solution and 10 mg / mL ZnCl 2 Solution; take 1mL of astragalus solution, mix 0.2mL of dopamine solution and place it on a magnetic stirrer and stir at 900rpm, then slowly add ZnCl dropwise to the mixture 2 The solution was 0.25 mL, and after the dropwise addition was completed, stirring was continued for 30 minutes at room temperature, and the dopamine-Zn-astragalin coordination precursor solution was obtained by the reaction. In the reaction, the input mass ratio of astragalin, dopamine and Zn ions was 5:2:1.19.

[0048] (2) Preparation of dopamine-Zn-astragalin coordination and π-π stacking self-assembled nanoparticles: Pluronic F127 was dissolved in 10 mM Tris-HCl buffer at a concentration of 1 mg / mL to form a surfactant solution . Take 10 mL of th...

Embodiment 2

[0075] (1) Preparation of dopamine-Zn-astragalin coordination precursor solution: firstly, astragalus and dopamine were dissolved in methanol to obtain 5 mg / mL astragalin solution and 10 mg / mL dopamine solution, and Zn(NO) 3 ) 2 Dissolved in DMSO to obtain 10 mg / mL of Zn(NO 3 ) 2 solution; take 1 mL of astragalus solution, mix 0.5 mL of dopamine solution and place it on a magnetic stirrer and stir at 900 rpm, then slowly add Zn(NO) dropwise to the mixture 3 ) 2 The solution was 0.2 mL, and after the dropwise addition was completed, stirring was continued for 60 minutes at room temperature, and the astragalin-Zn-dopamine coordination precursor solution was obtained by the reaction. In the system, the input mass ratio of astragalin, dopamine and Zn ions was 5:5:0.69.

[0076] (2) Preparation of dopamine-Zn-astragalin coordination and π-π stacking self-assembled nanoparticles: Pluronic F127 was dissolved in 5 mM Tris-HCl buffer at a concentration of 2 mg / mL to form a surfacta...

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Abstract

The invention relates to the technical field of nano-drugs, and provides a response slow-release type polydopamine-Zn-natural polyphenol coordination nano-drug and a preparation method thereof. The preparation method comprises the following steps: firstly, coordinating a natural polyphenol drug, dopamine and zinc ions, and then carrying out self-assembly of coordination precursor molecules and dopamine polymerization, so as to form the response slow-release type polydopamine-Zn-natural polyphenol coordination nano-drug. High-strength entrapment of a natural polyphenol drug is achieved through coordination bonds, pi-pi accumulation and polymer network steric hindrance in sequence, and under the weak acid pathological condition, binding force of the coordination bonds and the pi-pi accumulation in the nano-drug is weakened while a polydopamine network still exists; the escape threshold value of the natural polyphenol medicine is reduced but does not completely disappear, so that the response slow release of the natural polyphenol medicine is realized, and the delivery requirement of the natural medicine in chronic disease treatment is better met. The method disclosed by the invention is simple and convenient to operate, mild in reaction, high in universality and capable of remarkably enhancing the stability of the natural polyphenol medicine.

Description

technical field [0001] The invention relates to the technical field of nano-medicine, in particular to a response slow-release polydopamine-Zn-natural polyphenol coordination nano-medicine and a preparation method thereof. Background technique [0002] Polyphenolic natural medicines are one of the main types of natural medicines, including flavonoids, flavonoids, phenolic acids, stilbene, etc., with antioxidant, anti-inflammatory, antitumor, antiviral, neuroprotective, vascular protection and other It has good application potential in the treatment of various chronic metabolic diseases such as diabetes, non-alcoholic fatty liver and cardiovascular diseases. In recent years, with the deepening of human's understanding of natural medicines and the emergence of the defects of synthetic medicines, the recognition of natural medicines, especially polyphenolic natural medicines, has been increasing. However, in the process of use, polyphenols face problems such as poor water solu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/59A61K47/69A61K31/343A61K31/352A61K31/353A61K33/30A61P9/14A61P25/00A61P29/00A61P31/12A61P35/00A61P39/06B82Y5/00B82Y30/00B82Y40/00
CPCA61K47/6935A61K47/59A61K33/30A61K31/352A61K31/353A61K31/343A61P39/06A61P29/00A61P35/00A61P31/12A61P9/14A61P25/00B82Y5/00B82Y30/00B82Y40/00Y02A50/30
Inventor 肖伟烈唐鹏张芮菡张兴杰李晓莉李一明毕德文程彬倪冬暄武学文梁新新王梦如
Owner YUNNAN UNIV
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