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Process for preparing phenolic resin hollow fibre film for auxiliary respirator

A technology of phenolic resin and breathing assistance, which is applied in the preparation of hollow fiber materials and hollow fiber membrane materials. It can solve the problems of limited application range, easy penetration of plasma and water molecules, and failure to meet clinical needs, etc., and achieve long service life. , the effect of high gas exchange rate

Inactive Publication Date: 2004-10-27
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the uneven distribution of pores on the capillary wall and the easy penetration of blood plasma and water molecules, the existing breathing aids can only provide 30% of the oxygen demand of adults, and the service life is only 2 to 8 hours (Cox CS, Zwischenberger JB, Traber LD, et al. Use of an intravascular oxygenator IVOX inan ovine smoke inhalation injury model. ASAIO Trans, 1991, 37: M411-M413) The membrane materials used in biocompatibility, water, plasma permeability, selection of oxygen and carbon dioxide Performance aspects such as sex exchange cannot meet clinical needs, and its scope of use has been greatly limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of spinning dope

[0032] After mixing polyvinyl butyral (PVB) with a weight-average molecular weight of 300 and refined phenolic resin at a ratio of 1:1 (W / W), it was dissolved in methanol to make an 8% solution, and the solvent was distilled off under reduced pressure. Filtration and defoaming to make spinning stock solution;

[0033] (2) Preparation of hollow fiber

[0034] Using the melting method at a temperature of 150 ° C, the above spinning solution is prepared on a spinning machine to prepare novolac primary hollow fibers, which are biaxially stretched, washed, and then placed in an aqueous solution containing 0.1M formaldehyde and 0.1M hydrochloric acid. Crosslinking, Curing, curing for 0.5 hours, the inner diameter of the hollow fiber is 10-50 μm, and the outer diameter is 20-70 μm. Reticular phenolic resin hollow fiber;

[0035] (3) Oxidation and carbonization treatment

[0036] Place the above mesh hollow fiber in a furnace and slowly hea...

Embodiment 2

[0044] (1) Preparation of spinning dope

[0045] After mixing polyvinyl butyral (PVB) with a weight average molecular weight of 300 and refined phenolic resin by 1:3 (W / W), dissolve it in methanol to make a 10% solution, and distill off the solvent under reduced pressure. Filtration and defoaming to make spinning stock solution;

[0046] (2) Preparation of hollow fiber

[0047]Use the melting method at a temperature of 160°C to prepare novolac primary hollow fibers from the above spinning solution on a spinning machine, stretch them properly in two directions, wash them with water, and then place them in an aqueous solution containing 0.2M formaldehyde and 0.1M hydrochloric acid for crosslinking , curing for 0.5 hours, to obtain hollow fibers with a hollow fiber inner diameter of 8-100 μm and an outer diameter of 18-150 μm reticular phenolic resin hollow fibers;

[0048] (3) Oxidation and carbonization treatment

[0049] Place the above mesh hollow fiber in the furnace and ...

Embodiment 3

[0057] (1) Preparation of spinning dope

[0058] After mixing polyvinyl butyral (PVB) with a weight-average molecular weight of 300 and refined phenolic resin by 1:6 (W / W), dissolve it in methanol to make a 15% solution, and distill off the solvent under reduced pressure. Filtration and defoaming to make spinning stock solution;

[0059] (2) Preparation of hollow fiber

[0060] Use the melting method at a temperature of 180°C to prepare the novolac primary hollow fiber from the above spinning solution on a spinning machine, stretch it properly in two directions, wash it with water, and then place it in an aqueous solution containing 0.1M glutaraldehyde and 0.2M hydrochloric acid Cross-linking and curing for 1 hour to obtain a reticular phenolic resin hollow fiber with an inner diameter of 8-100 μm and an outer diameter of 18-150 μm;

[0061] (3) Oxidation and carbonization treatment

[0062] Place the above mesh hollow fiber in the furnace and slowly raise the temperature t...

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PUM

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Abstract

The present invention belongs to the field of bioengineering material technology. PVB material and phenolic resin in the weight ratio of 1 to 1-10 are mixed and dissolved in methanol to prepare 8-28 % concentration solution; the solution is produced into spinning dope through reduced pressure distillation, filtering and debubbling; and the spinning dope is further produced into hollow phenolic resin fiber film through stretching, carbonation, strengthening, toughening, anticoagulation and other specific steps. The material is non-toxic, has no toxic side effect, and may be used clinically; and it may be used in auxiliary respirator for extraneous and intracorporal use.

Description

technical field [0001] The invention relates to a method for preparing a hollow fiber material, in particular to a method for preparing a hollow fiber membrane material used in a breathing aid device, and belongs to the technical field of bioengineering materials. Background technique [0002] Respiratory assistance device is a kind of auxiliary treatment for patients with respiratory failure. In addition to oxygen inhalation, medical support, and anti-inflammatory methods, the traditional treatment mainly uses mechanical ventilation, which is often accompanied by barotrauma leading to further lung injury. The ideal treatment is to correct hypoxia and hypercapnia as soon as possible and effectively without causing additional damage to the body. Various breathing assistance devices have thus been produced. There are three types of respiratory assistance devices currently in use: bubble type, blood film type, and membrane type (Liu Qingjun, Artificial Organs, 1984: P46-48). ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/18A61M16/00B01D69/08B01D71/38
Inventor 崔福斋王小红冯庆玲
Owner TSINGHUA UNIV