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Medicinal complex dibaicalin zinc and its preparation method

A technology of zinc baicalin and baicalin, which is applied in the field of complexes of baicalin and zinc, can solve problems such as not being conducive to ensuring the quality stability of industrial production products, reducing industrial production efficiency, and low solubility, and achieving stable quality. control, increase production efficiency, and anti-ulcer activity

Inactive Publication Date: 2005-07-27
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Baicalin has low solubility under neutral and acidic conditions, and is easily soluble in water or a certain proportion of alcohol aqueous solution under alkaline conditions, but it is unstable, which is not conducive to ensuring the quality stability of industrial production products
Its two, the baicalin zinc prepared by the above-mentioned process is difficult to filter when cleaning excessive zinc ions, which reduces the efficiency of industrial production

Method used

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  • Medicinal complex dibaicalin zinc and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Baicalin (purity 95%) is commercially available; analytically pure zinc sulfate heptahydrate is produced by Beijing Shuangyan Chemical Plant; analytically pure methanol is produced by Beijing Chemical Plant.

[0056] Add 5.00 g of baicalin into a 250 ml round bottom flask, add 100 ml of water, place on a magnetic stirrer, and fix. 5.91 grams of zinc sulfate were dissolved in 150 milliliters of methanol, and put into a 250 milliliter separatory funnel for subsequent use, and the separatory funnel was placed above the round bottom flask. Adjust the stirring speed to fully disperse the solids, and continue stirring for 20 minutes. The zinc solution was added dropwise, and an orange-red precipitate was formed in the solution immediately. Continue to add the zinc solution dropwise until it is completely added. Stirring was stopped and left to stand for 1 hour. Remove the supernatant, stir the residue with a glass rod to suspend it, put it into a triangular funnel with fil...

Embodiment 2

[0058] Baicalin (purity 95%) is commercially available, analytically pure zinc acetate monohydrate is produced by Beijing Shuangyan Chemical Plant; edible alcohol (95%) is produced by Beijing Chemical Plant.

[0059] Put 4.46 grams of baicalin (purity 95%) into a 250 milliliter round bottom flask, add 100 milliliters of water and 30% ethanol solution, place it on a magnetic stirrer, and fix it. 1.11 grams of zinc acetate was dissolved in 100 milliliters of 30% ethanol solution, and put into a 250 milliliter separatory funnel for subsequent use, and the separatory funnel was placed above the round bottom flask. Adjust the stirring speed to fully disperse the solids, and continue stirring for 20 minutes. Zinc acetate solution was added dropwise, and an orange-red precipitate was immediately formed in the solution. Continue to add zinc acetate dropwise until it is completely added. Stirring was stopped and left to stand for 1 hour. Remove the supernatant, stir the residue with...

Embodiment 3

[0061] Reagents and materials:

[0062] Baicalin (purity 95%), commercially available; zinc chloride, acetone is analytically pure, produced by Beijing Chemical Factory; edible alcohol (95%)

[0063] Add 5.12 grams of baicalin (purity 95%) into a 250 milliliter round bottom flask, add 100 milliliters of 60% ethanol solution, place it on a magnetic stirrer, and fix it. 3.01 grams of zinc chloride were dissolved with 150 milliliters of 30% acetone aqueous solution, and put into a 250 milliliter separatory funnel for subsequent use, and the separatory funnel was placed above the round bottom flask. Adjust the stirring speed to fully disperse the solids, and continue stirring for 20 minutes. Zinc acetate solution was added dropwise, and an orange-red precipitate was immediately formed in the solution. Continue to add zinc chloride dropwise until it is completely added. Stirring was stopped and left to stand for 1 hour. Remove the supernatant, stir the residue with a glass rod ...

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Abstract

A medical complex, bibaicalin zinc, used for preparing antibacterial, anti-inflammatory and anti-ulcerative medicines is prepared through mixing baicalin with water and / or organic solvent to obtain suspension, preparing the solution of zinc salt, adding the zinc salt solution to the suspension while stirring, laying aside, filtering to obtain deposit, washing with mixture of alcohol and water and drying. Its advantages are simple process, and stable activity.

Description

technical field [0001] The present invention relates to a pharmaceutical compound, more specifically, the present invention relates to a complex of baicalin and zinc, and the present invention also relates to the preparation method and application of the complex. Background technique [0002] Baicalin is the main active ingredient of the traditional Chinese medicine Scutellaria baicalensis, which has good pharmacological activities of antibacterial, anti-inflammatory and anti-allergic. Zinc ions have astringent effect and are widely present in various mineral medicines. At the same time, zinc is one of the important trace elements in the human body. The complex of baicalin and zinc has strong antibacterial, anti-inflammatory and analgesic effects (see "Shi Zhen Guo Yi Guo Yao, 1999, 10(2): 152"). At the same time, the baicalin zinc complex has good stability. [0003] The complexes of baicalin and zinc obtained under different reaction conditions may have differences in s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7135A61P29/00A61P31/04C07H17/07
Inventor 罗国安肖盛元王义明叶能胜
Owner TSINGHUA UNIV
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