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Artificial bone material

A bone and artificial technology, used in bone implants, ceramic products, prostheses, etc., can solve the problems of poor manufacturing process and great influence of raw materials, and achieve the effect of ensuring bone formation, improving practicability, and promoting bone formation.

Inactive Publication Date: 2006-02-15
OLYMPUS CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The properties of the raw material are greatly influenced by the manufacturing process, whose poor manufacturing process can lead to undesired results during the use phase, and said influence has not been studied at all in the past

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh calcium carbonate powder and calcium hydrogen phosphate dihydrate with a molar ratio of 1:2, put them into the bowl of a ball mill together with pure water, and mix and pulverize with a ball mill for about 1 day. The slurry mixture obtained was dried at about 80°C and then calcined at 750°C. The obtained powder is β-TCP ceramic with excellent sinterability and high purity.

[0037] Add pure water, ammonium acrylic coagulant and polyoxyethylene alkyl phenyl ether surfactant to the powder, mix and stir to prepare foaming slurry. The foamed slurry is dried and then fired at 150°C to obtain β-TCP porous ceramics. The porosity of the porous ceramic is 75%, and the pore diameters are distributed in two ranges of 100-500 μm and 1-0.1 μm.

Embodiment 2

[0039] Using the β-TCP porous ceramic produced in Example 1 as the basic material, the first-generation cultured cells of osteoblasts derived from bone marrow were seeded and cultured in vitro to form the bone tissue of the bone-forming seeds, which were implanted in the organism, from the implanted The tissue forms a large amount of bone tissue. The specific method is as follows.

[0040] Take bone marrow cells and inoculate them into culture flasks, add 10-15% FBS (fetal bovine serum), 5% CO 2 Then, incubate at 37°C for about 10 days. Then the cells are separated from the culture flask by trypsin treatment, and then seeded into a block porous ceramic formed of β-TCP. As the medium, MEM medium containing 10-15% FBS (fetal bovine serum) was used.

[0041]When seeding a porous ceramic block of 5 mm × 5 mm × 5 mm, a medium with a cell concentration of 1 cc contains 1 million or more cells. At 5% CO 2 After culturing at 37°C for 1-3 hours at a constant temperature, change the medium,...

Embodiment 3

[0044] The β-TCP porous ceramic prepared in Example 1 was sowed with cell proliferation factors adsorbed on it. As cell growth factors, VEGF, BMP, FGF, FGF-β, IGF, and PDGF were used. Cultured in vitro, the bone tissue that forms the seeds of bone formation is implanted into the living body, and a large amount of bone tissue is formed from the implanted tissue. The specific method is as follows.

[0045] Take the above cell proliferation factors separately, inoculate them into culture flasks, add 10-15% FBS (fetal bovine serum) to MEM medium, and add them to 5% CO 2 Then, incubate at 37°C for about 10 days. Then the cells are separated from the culture flask by trypsin treatment, and then seeded into the block porous ceramic formed by β-TCP. As the medium, MEM medium containing 10-15% FBS (fetal bovine serum) was used.

[0046] When seeding, the seeding methods of each cell proliferation factor were seeding under reduced pressure, seeding under pressure, and seeding under repeated...

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Abstract

An artificial bone material having a satisfactory compatibility with a human body and capable of effecting osteogenesis satisfactorily which is obtained by integrating a marrow cell in a porous ceramic consisting of beta-tricalcium phosphate.

Description

Technical field [0001] The invention relates to an artificial bone material used for bone injury repair. Background technique [0002] In recent years, artificial bone materials have been widely used in plastic surgery and other fields to repair bone damage caused by various diseases. As artificial bone materials, calcium dihydrogen phosphate ceramics are mainly used. Calcium dihydrogen phosphate ceramic materials have excellent biocompatibility, good osteoconductivity, and serve as the basis for bone formation. However, when bone damage is severe, it is difficult to repair the bone damage by using calcium dihydrogen phosphate ceramic materials alone. Therefore, in such cases, only one's own bone can be transplanted. However, due to the limitation of bone collection, it is difficult to repair the bone injury. [0003] Based on this background, in cases of severe bone damage, materials with higher bone formation ability, that is, graft materials with osteoinductive activity, are e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28A61F2/00A61L27/12A61L27/00A61L27/38A61L27/56C04B35/447C04B38/02
CPCA61F2/28A61L27/3821A61L2430/02A61L27/12A61L27/56A61F2310/00293A61L27/3895
Inventor 袴塚康治入江洋之井上晃増渕良司冈部洋植村寿公
Owner OLYMPUS CORP
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