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Preparation method of hongjintian effective component extract

An active ingredient, the technology of Rhodiola rosea, applied in the field of phytochemistry, can solve the problems of limited resources, low content, and few types of Rhodiola rosea medicinal materials, and achieve the effect of simple process, less organic solvent residue, and increased content of active ingredients

Inactive Publication Date: 2006-03-22
上海纳贝生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The content of Rosavin in the original medicinal materials of Rhodiola is very low, because the chemical polarity of Rosavin and salidroside is very close, from the perspective of thin layer chromatography (TLC), the Rf values ​​of the two are close, it is difficult to separate the two Those are separated, so the process of preparing Rosavin monomer is more difficult
In addition, there are very few types of Rhodiola rosea medicinal materials containing Rosavin as an active ingredient, and the resource conditions are relatively limited, so this is undoubtedly a constraint on the large-scale development of Rhodiola rosea health care products.

Method used

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  • Preparation method of hongjintian effective component extract
  • Preparation method of hongjintian effective component extract
  • Preparation method of hongjintian effective component extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Get the former medicinal material 200g of Rhodiola rosea, grind, extract three times with 65% ethanol solution, the amount of adding ethanol is respectively 1200ml, 1000ml, 800ml at every turn, obtains the extract, concentrates and weighs 19.4g of the extractum, then Extract three times with ethyl acetate (1:1) and n-butanol (1:1) respectively, take the n-butanol extract, concentrate and weigh 5.3g, add 3 times of water to dissolve, decolorize with activated carbon and weigh 3.8g , on the D-101 macroporous resin exchange column, first eluted with water, and then used 10%, 30%, 50%, 70%, 90% ethanol for gradient elution, and collected 50-70% of the eluted Parts, 1.2g of the effective part extract of Rhodiola rosea was obtained, including about 1.03g of salidroside and 0.011g of roseavid.

Embodiment 2

[0028] Get 1kg of the former medical material of Rhodiola rosea, grind it, dissolve and extract it three times with 75% ethanol, obtain the extract, concentrate the back extractum and weigh 118g, then use ethyl acetate (1: 1) and n-butanol (1: 1) Extract three times respectively, take n-butanol extract, concentrate to obtain 26.7g, after dissolving in 4 times the amount of water, decolorize with activated carbon to obtain 14.5g, put on AB-8 type macroporous resin exchange column, first elute with water, then Use 30%, 50%, 70%, 90% ethanol gradient elution, collect 50-70% of the eluted parts, and obtain 4.9g of the effective part extract of Rhodiola rosea, of which 2.79g of salidroside, locet Dimension is 1.74g.

Embodiment 3

[0030] Get 2kg of the raw material of Rhodiola rosea, grind it, dissolve and extract it three times with 85% ethanol, obtain the extract, concentrate the back extractum and weigh 237g, then use ethyl acetate (1: 1) and n-butanol (1: 1) Extracted three times respectively, took the n-butanol extract, concentrated to obtain 58.7g, dissolved in 5 times of water, decolorized with activated carbon to obtain 30.2g, put on the D-101 type macroporous resin exchange column, first eluted with water, and then used 30 %, 50%, 70%, and 90% ethanol for gradient elution, and collected 50-70% of the eluted parts to obtain 11.4g of the effective part extract of Rhodiola rosea, including 2.39g of salidroside and roseavid It is 8.21g.

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Abstract

A process for extracting the active components from rhodiola root is disclosed. Said active components includes sedride (5-95%) and Luosaiwei (5-95%).

Description

technical field [0001] The invention belongs to the technical field of phytochemistry. Specifically, it relates to a preparation method of an active ingredient extract of Rhodiola rosea. Background technique [0002] Rhodiola rosea (Rhodiola rosea) is a perennial herb or shrub plant, mainly distributed in the Far East of the former Soviet Union and the alpine regions of Northeast, Northwest, and Southwest China. Its pharmacological activity is similar to that of Siberian ginseng, Ganoderma lucidum, and American ginseng, mainly in: Anti-hypoxia, anti-fatigue, anti-microwave radiation, scavenging free radicals in the body, regulating and restoring the metabolic balance of the human body. Among them, the most studied active ingredients are salidroside and aglycone tyrosol (Tyrosol). With the continuous deepening of research at home and abroad, it is found that there is a component in rhodiola that is more active than salidroside—— Roseville, and this active ingredient has bee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H1/08
Inventor 尉亚辉栾龙张少勇董红元姜涛
Owner 上海纳贝生物技术有限责任公司