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Compound vitamin U atropa belladonna bismuth-aluminium medicine table for treating gastric ulcer

A technology for bismuth-aluminum eggplant tablets and gastric ulcer disease, which is applied in the field of double-layer tablets for the treatment of gastric ulcer disease, and can solve the problem that detailed information of auxiliary materials is not disclosed.

Active Publication Date: 2007-05-09
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How this medicine can achieve its due curative effect, those skilled in the art know that excipients are a very important factor, but there is no detailed information on excipients in the Pharmacopoeia

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Compound vitamin U belladonna bismuth aluminum sheet of the present invention, its composition is:

[0024] Inner core layer: Vitamin U 25mg, glycyrrhizic acid 12.5mg, microcrystalline cellulose 27.3mg, magnesium stearate 0.83mg.

[0025] Outer coating: bismuth subcarbonate 100mg, aluminum hydroxide 75mg, nacre powder 100mg, sodium copper chlorophyllin 1.0mg, belladonna liquid extract 0.0026mg, microcrystalline cellulose 50mg, lactose 66.7mg, pregelatinized starch 50mg, poly Povidone K-30 is 13.3mg, povidone K-90D is 6.7mg, ethanol is 202.7ml, sodium starch glycolate is 14.4mg, magnesium stearate is 3.35mg, and fumed silicon dioxide is 1.44mg.

[0026] The manufacturing method of the invention is as follows: firstly, all the raw and auxiliary materials of the inner core layer are mixed and pressed into tablets, and the hardness of the tablets is 2kg-4kg. After mixing all the raw and auxiliary materials of the outer cladding layer, add copper sodium copper chlorophyllin...

Embodiment 2

[0028] The composition of the inner core layer is: 25 mg of vitamin U, 12.5 mg of glycyrrhizic acid, 28.675 mg of microcrystalline cellulose, and 0.87 mg of magnesium stearate.

[0029] The composition of the outer coating is: bismuth subcarbonate 100mg, aluminum hydroxide 75mg, nacre powder 100mg, sodium copper chlorophyllin 1.0mg, belladonna liquid extract 0.0026mg, microcrystalline cellulose 52.5mg, lactose 70.04mg, pregelatinized starch 52.5mg, povidone K-30 13.96mg, povidone K-90D 7.05mg, ethanol 212.84ml, sodium starch glycolate 15.12mg, magnesium stearate 3.52mg, fumed silicon dioxide 1.51mg.

Embodiment 3

[0031] The composition of the inner core layer is: 25 mg of vitamin U, 12.5 mg of glycyrrhizic acid, 25.93 mg of microcrystalline cellulose, and 0.79 mg of magnesium stearate.

[0032] The composition of the outer coating is: bismuth subcarbonate 100mg, aluminum hydroxide 75mg, nacre powder 100mg, sodium copper chlorophyllin 1.0mg, belladonna liquid extract 0.0026mg, microcrystalline cellulose 47.5mg, lactose 63.36mg, pregelatinized starch 47.5mg, Povidone K-30 12.64mg, Povidone K-90D 6.36mg, Ethanol 192.56ml, Carboxymethyl starch sodium 13.65mg, Magnesium stearate 3.18mg, Fumed silicon dioxide 1.37mg.

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PUM

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Abstract

The present invention relates to a compound vitamin U belladonna bismuth aluminium tablet drug for curing gastric ulcer. It discloses the mixture of internal core layer auxiliary materials and mixture of external covering layer auxiliary materials of said drug. Its active component has the functions of resisting ulcer and promoting healing of wound surface and regeneration of gastric mucosa.

Description

technical field [0001] The invention relates to an antigastric ulcer drug for human, in particular to a double-layer tablet medicine for treating gastric ulcer disease. Background technique [0002] Vitamin U has a healing effect on gastric mucosal ulcers, so vitamin U used in the treatment of gastric diseases has been used for a long time. Although vitamin U with a single active ingredient has the effect of promoting the healing of gastric mucosal ulcers, the effect is unsatisfactory, mainly because it cannot quickly relieve and stop the pain of the stomach. For this reason, a new generation of gastric medicine has been developed, which is the National Drug Standard WS-10001-(HD-0364)-2002 "Compound Vitamin U Belladonna Bismuth Aluminum Tablets formulated by the State Drug Administration. This medicine can Antacid, pain relief, and promote the healing of gastric mucosal ulcers. It is divided into dosage forms of inner core layer tablet and outer coating layer tablet (outer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/56A61K36/00A61K31/704A61K9/20A61P1/04A61K35/618
Inventor 李荣基
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY