Cyclodextrin cross-linking polymeric microsphere capable of absorbing bilirubin and its preparation and application
A cross-linked polymer and cyclodextrin technology, applied in other chemical processes, chemical instruments and methods, etc., can solve the problems of poor selectivity and blood compatibility, cumbersome preparation process of adsorption materials, unsatisfactory removal effect, etc., to achieve Simple preparation process, good clinical application potential, high removal efficiency and high selectivity
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Embodiment 1
[0018] A bilirubin adsorbent microsphere, which uses a cyclodextrin compound as a monomer and 1,6-hexamethylene diisocyanate as a crosslinking agent;
[0019] The synthetic method of the granular cross-linked polymer that adsorbs bilirubin is as follows:
[0020] 1) Weigh a certain amount (0.3510g) of cyclodextrin and dissolve it in 20mL of dry dimethyl sulfoxide, and sonicate it at 20°C for 30 minutes to completely dissolve it;
[0021] 2) Take a certain amount (1.2ml or 1.8ml) of 1,6-hexamethylene diisocyanate and pour it into the DMSO solution of step 1) cyclodextrin, and continue to sonicate for 5 minutes to obtain a uniform solution;
[0022] 3) Pour the homogeneous mixture in step 2) into a 50mL round-bottomed flask that has been purged with nitrogen for 5 minutes in advance, put in a magnet, seal the flask, and stir and react for 6 hours at 45°C;
[0023] 4) The polymer particles obtained in step 3) were thoroughly rinsed with acetone, hot water, and hot ethanol in seq...
Embodiment 2
[0031] A bilirubin adsorbent microsphere, which uses cyclodextrin compounds as monomers and diphenylmethane-4,4'-diisocyanate as crosslinking agent;
[0032] The synthetic method of the granular cross-linked polymer that adsorbs bilirubin is as follows:
[0033] 1) Weigh a certain amount of cyclodextrin and dissolve it in 20mL of dry dimethyl sulfoxide, and sonicate it at 50°C for 10 minutes to completely dissolve it;
[0034] 2) Measure a certain amount of diphenylmethane-4,4'-diisocyanate and pour it into the DMSO solution of step 1) cyclodextrin, and continue ultrasonication for 15 minutes to obtain a uniform solution;
[0035] 3) Pour the homogeneous mixture in step 2) into a 50mL round-bottomed flask that has been purged with nitrogen for 10 minutes in advance, put in a magnet, seal the flask, and stir and react for 1 hour at 80°C;
[0036] 4) The polymer particles obtained in step 3) were thoroughly rinsed with acetone, hot water, and hot ethanol in sequence to remove u...
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