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Medicine for treating leukopenia and its preparing method

A technology for leukopenia and therapeutic drugs, applied in drug combinations, pharmaceutical formulations, extracellular fluid diseases, etc., can solve problems such as fever and pyrogen reactions, and achieve the effects of low dosage, high therapeutic index, and high biological activity

Inactive Publication Date: 2007-08-01
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the defects of existing bioengineering drugs that produce fever and pyrogen reaction to leukopenia

Method used

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  • Medicine for treating leukopenia and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1, leukopenia treatment drug-bacterial polysaccharide nasal drops is made of the following component raw materials (consumption is parts by weight): 0.1 part of bacterial polysaccharide, 10 parts of low-molecular-weight dextran, 5 parts of sodium glycocholate, no 500 parts of bacterial water, wherein the low molecular weight dextran can be replaced by 10 parts of mannitol equivalent.

[0051] The specific operation method is as follows:

[0052] (1) Preparation of bacterial polysaccharides: ① inoculate the S. marcescens strains in common broth medium, 28--30 ° C, 24-30 hours; ② select single colony bacteria and culture them in common agar medium, 30°C, 24-30 hours; ③ Inoculate in shake flask culture solution, place in a constant temperature shaking incubator, shake frequency 80--130 times / min, and cultivate for 20-25 hours; ④ Shake flask culture solution inoculate in fermentation tank In the culture medium, ferment for 40-48 hours at 28-30°C; ⑤centrifuge the...

Embodiment 2

[0054] Embodiment 2, the bacterial polysaccharide spray is made of the following components (amounts are parts by weight): 0.2 parts of bacterial polysaccharide, 20 parts of low molecular weight dextran, 10 parts of sodium glycocholate, and 1000 parts of sterile water. Its preparation method is the same as that of Example 1, except that it is divided into spray bottles.

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Abstract

An externally-applied medicine for treating the leukocytopenia caused by chemicotherapy or radiotherapy is composed of the freeze-dried bacteropolyose powder prepared from bacterial powder through enzymolyzing, extracting and freeze drying, and the promoter consisting of sodium glycocholate and aseptic water.

Description

technical field [0001] The invention relates to a drug for treating leukopenia and a preparation method thereof, which is made from bacterial polysaccharides and belongs to external administration preparations. Background technique [0002] At present, the incidence of tumors, cancers, and blood system diseases is increasing year by year all over the world. Radiation and chemotherapy must be used in the treatment process to inhibit the bone marrow hematopoietic system, damage bone marrow hematopoietic cells, cause various blood cells to decrease, and lead to hematopoietic dysfunction. The main reason is the toxic effect of radiation and chemotherapy on bone marrow cells. Most anticancer drugs have poor selectivity for killing tumor cells. Radiotherapy and chemotherapy take a long time and have a large dose, which has a strong toxic effect on bone marrow cells, causing hematopoietic dysfunction and reducing blood cells such as granulocytes, erythroids, giants, and lymphocytes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/721A61P35/00A61P7/00C12P19/04
Inventor 李延平刘义
Owner GUANGDONG MEDICAL UNIV
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