Synthesis of potassium acetylsulfanilate

Abstract

The present invention relates to the preparation of acetyl potassium sulfanilate; preparation of substituted phenoxy sulfamide; preparation of acetyl acetoamino-N-sulfuryl-substituted phenoxyl; preparation of acetyl potassium sulfanilate. The present invention is simple in technology, relatively short reaction time, easy treatment of wastes.

Description

(1) Technical field [0001] The invention relates to a method for preparing chemical substances, in particular to a method for synthesizing and preparing acesulfame potassium. (2) Background technology [0002] The chemical synthesis method of acesulfame potassium has the following several at present: [0003] (1) With fluorine or chlorosulfonyl isocyanate (FSO 2 NCO or ClSO 2 NCO) reacts with isobutyl acetoacetate. In this method, the intermediate chlorosulfonyl isocyanate needs to be prepared with highly toxic NaCN. Because NaCN is a highly toxic drug and is prone to personal death, it is not suitable for industrial production. In addition, this reaction is carried out at low temperature, which consumes a lot of energy and increases the cost of the product. Therefore, this method is not suitable for industrial production. [0004] (2) Reaction of acetoacetamide with fluorosulfonyl. [0005] (3) Diketene reacts with aminofluorosulfonyl. [0006] In (2), (3) method, SO ...

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Problems solved by technology

[0010] In this patent, deficiency one: the first (2) step uses NaN 3 For the generated azide, when distilling the solvent, the temperature should not exceed 25°C, otherwise it will easily cause an explosion. If the temperature does not exceed 25°C, the residual solvent is not easy to remove, which will affect the next reaction and yield

Weakness two: the first (3) step with NaBH 4 To reduce azide, the reducing agent used NaBH 4 Insoluble in tetrahydrofuran, only its suspension can be used, the reduction time is very long, the effect is not ideal, and the yield fluctuates.