Cosmetics composition containing aminophenol derivatives and isoflavone like substance

A kind of aminophenol, technology of composition, applied in the field of composition

Inactive Publication Date: 2002-06-12
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the best of the applicant's knowledge, there is no t

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiments of the Invention Example 1: Demonstration of the synergistic effect of the compounds of the present invention

[0060] In vitro biological tests (inhibition of fungal tyrosinase) demonstrate the depigmentation activity of the combined application of the compounds of the present invention.

[0061] The test consists in the determination of the absorbance (optical density OD) at a wavelength of 475 nm as a function of time for each active depigmenting agent to be tested.

[0062] Dissolve these reagents (at various concentrations) in a suitable solvent containing phosphate buffered saline, 1 ml of 2.0 x 10 -3 M L-tyrosine in phosphate buffered saline, 0.1 ml 1.0 x 10 -4 The phosphate buffer solution of L-dopa of M and the phosphate buffer solution of the fungal tyrosinase of 50 microliters concentration are 1g / L, and the reference substance is made up of the solvent containing the same concentration of phosphate buffer solution. Percent inhibition was calcul...

Embodiment 2

[0067] Since the test was accurate (around 5%), the synergistic effect of the combined application of these two compounds was clearly demonstrated. Example 2: Oleosome-type O / W fluid

[0068] Prepare the following compositions, and the weight percentages of each composition are as follows

[0069] Phase A

[0070] N-ethoxycarbonyl-4-aminophenol 0.5%

[0071] Stearyl Enanthate and Stearyl Caprylate 5.5%

[0072] Vegetable oil 11.6%

[0073] UVA masking agent 1.9%

[0074] Cyclopentasiloxane 3.7%

[0075] Sucrose Tristearate 2.0%

[0076] Oxyethylated (4EO) sorbitan monostearate 1.35%

[0077] Stearic acid 1.0%

[0078]Oxyethylated (60EO) Hydrogenated Castor Oil 2.5%

[0079] Tocopheryl acetate 0.5%

[0080] Phase B

[0081] Fujiflavone P40 (Maruzen) 0.1%

[0082] Preservatives 0.29%

[0083] Triethanolamine 0.50%

[0084] Disodium EDTA 0.05%

[0085] Glycerin 3.0%

[0086] Add water to 100.0%

[0087] Get a bleaching fluid for your face.

[0088] It can be obt...

Embodiment 3

[0088] It can be obtained by heating phase A and phase B separately to 65°C and then cooling them to room temperature. Then add phase B into phase A to obtain a W / O emulsion, which is then homogenized in a high-pressure homogenizer (500b, 1-3 times). Example 3: Grease body-type O / W fluid

[0089] Prepare the following compositions, and the weight percentages of each composition are as follows

[0090] Phase A

[0091] N-ethoxycarbonyl-4-aminophenol 0.5%

[0092] Stearyl Enanthate and Stearyl Caprylate 5.5%

[0093] Vegetable oil 11.6%

[0094] UVA masking agent 1.9%

[0095] Cyclopentasiloxane 3.7%

[0096] Sucrose Tristearate 2.0%

[0097] Oxyethylated (4EO) sorbitan monostearate 1.35%

[0098] Stearic acid 1.0%

[0099] Oxyethylated (60EO) Hydrogenated Castor Oil 2.5%

[0100] Tocopheryl acetate 0.5%

[0101] Phase B

[0102] Flavosterone SB (Ichimaru Pharcos) 10.0%

[0103] Preservatives 0.29%

[0104] Triethanolamine 0.50%

[0105] Disodium EDTA 0.05%

[01...

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PUM

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Abstract

The present invention relates to a composition comprising at least an aminophenol derivative and at least an isoflavonoid in a physiologically acceptable medium. The invention also relates a usage of the composition in producing the decolorization and/or the bleaching preparation for the skin. These combinations of active agents show synergism in the depigmentation and/or bleaching of the skin.

Description

technical field [0001] The present invention relates to a composition comprising at least one aminophenol derivative and at least one isoflavonoid in a physiologically acceptable medium; Use in cosmetic and / or dermatological preparations for depigmentation and / or bleaching of human skin. Background technique [0002] Over the years, many attempts have been made to come up with harmless highly effective topical depigmenting substances. Most particularly needed are these highly potent substances for the treatment of: Regional hyperactivity of melanocytes (e.g. idiopathic melasma, during pregnancy ("gravid spots" or melasma) or during estrogen-progestin contraception) Hyperpigmentation, localized hyperpigmentation due to benign melanocytic hyperplasia and hyperactivity (eg, age spots known as actinic lentigo, sporadic hyperpigmentation, or depigmentation, which may result from photosensitization or post-lesional scarring), and certain leukoplakia diseases, such as vitiligo. ...

Claims

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Application Information

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IPC IPC(8): A61K8/30A61K8/00A61K8/02A61K8/06A61K8/41A61K8/42A61K8/46A61K8/49A61Q17/04A61Q19/00A61Q19/02
CPCA61K8/498A61K8/411A61K8/415A61Q19/02A61K8/42A61K8/49
Inventor V·舍瓦利耶D·M·法姆
Owner LOREAL SA
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