Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cosmetics composition containing aminophenol derivatives and isoflavone like substance

A kind of aminophenol, technology of composition, applied in the field of composition

Inactive Publication Date: 2002-06-12
LOREAL SA
View PDF7 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the best of the applicant's knowledge, there is no technology for combining isoflavones with aminophenol derivatives

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiments of the Invention Example 1: Demonstration of the synergistic effect of the compounds of the present invention

[0060] In vitro biological tests (inhibition of fungal tyrosinase) demonstrate the depigmentation activity of the combined application of the compounds of the present invention.

[0061] The test consists in the determination of the absorbance (optical density OD) at a wavelength of 475 nm as a function of time for each active depigmenting agent to be tested.

[0062] Dissolve these reagents (at various concentrations) in a suitable solvent containing phosphate buffered saline, 1 ml of 2.0 x 10 -3 M L-tyrosine in phosphate buffered saline, 0.1 ml 1.0 x 10 -4 The phosphate buffer solution of L-dopa of M and the phosphate buffer solution of the fungal tyrosinase of 50 microliters concentration are 1g / L, and the reference substance is made up of the solvent containing the same concentration of phosphate buffer solution. Percent inhibition was calcul...

Embodiment 2

[0067] Since the test was accurate (around 5%), the synergistic effect of the combined application of these two compounds was clearly demonstrated. Example 2: Oleosome-type O / W fluid

[0068] Prepare the following compositions, and the weight percentages of each composition are as follows

[0069] Phase A

[0070] N-ethoxycarbonyl-4-aminophenol 0.5%

[0071] Stearyl Enanthate and Stearyl Caprylate 5.5%

[0072] Vegetable oil 11.6%

[0073] UVA masking agent 1.9%

[0074] Cyclopentasiloxane 3.7%

[0075] Sucrose Tristearate 2.0%

[0076] Oxyethylated (4EO) sorbitan monostearate 1.35%

[0077] Stearic acid 1.0%

[0078]Oxyethylated (60EO) Hydrogenated Castor Oil 2.5%

[0079] Tocopheryl acetate 0.5%

[0080] Phase B

[0081] Fujiflavone P40 (Maruzen) 0.1%

[0082] Preservatives 0.29%

[0083] Triethanolamine 0.50%

[0084] Disodium EDTA 0.05%

[0085] Glycerin 3.0%

[0086] Add water to 100.0%

[0087] Get a bleaching fluid for your face.

[0088] It can be obt...

Embodiment 3

[0088] It can be obtained by heating phase A and phase B separately to 65°C and then cooling them to room temperature. Then add phase B into phase A to obtain a W / O emulsion, which is then homogenized in a high-pressure homogenizer (500b, 1-3 times). Example 3: Grease body-type O / W fluid

[0089] Prepare the following compositions, and the weight percentages of each composition are as follows

[0090] Phase A

[0091] N-ethoxycarbonyl-4-aminophenol 0.5%

[0092] Stearyl Enanthate and Stearyl Caprylate 5.5%

[0093] Vegetable oil 11.6%

[0094] UVA masking agent 1.9%

[0095] Cyclopentasiloxane 3.7%

[0096] Sucrose Tristearate 2.0%

[0097] Oxyethylated (4EO) sorbitan monostearate 1.35%

[0098] Stearic acid 1.0%

[0099] Oxyethylated (60EO) Hydrogenated Castor Oil 2.5%

[0100] Tocopheryl acetate 0.5%

[0101] Phase B

[0102] Flavosterone SB (Ichimaru Pharcos) 10.0%

[0103] Preservatives 0.29%

[0104] Triethanolamine 0.50%

[0105] Disodium EDTA 0.05%

[01...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a composition comprising at least an aminophenol derivative and at least an isoflavonoid in a physiologically acceptable medium. The invention also relates a usage of the composition in producing the decolorization and / or the bleaching preparation for the skin. These combinations of active agents show synergism in the depigmentation and / or bleaching of the skin.

Description

technical field [0001] The present invention relates to a composition comprising at least one aminophenol derivative and at least one isoflavonoid in a physiologically acceptable medium; Use in cosmetic and / or dermatological preparations for depigmentation and / or bleaching of human skin. Background technique [0002] Over the years, many attempts have been made to come up with harmless highly effective topical depigmenting substances. Most particularly needed are these highly potent substances for the treatment of: Regional hyperactivity of melanocytes (e.g. idiopathic melasma, during pregnancy ("gravid spots" or melasma) or during estrogen-progestin contraception) Hyperpigmentation, localized hyperpigmentation due to benign melanocytic hyperplasia and hyperactivity (eg, age spots known as actinic lentigo, sporadic hyperpigmentation, or depigmentation, which may result from photosensitization or post-lesional scarring), and certain leukoplakia diseases, such as vitiligo. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/30A61K8/00A61K8/02A61K8/06A61K8/41A61K8/42A61K8/46A61K8/49A61Q17/04A61Q19/00A61Q19/02
CPCA61K8/498A61K8/411A61K8/415A61Q19/02A61K8/42A61K8/49
Inventor V·舍瓦利耶D·M·法姆
Owner LOREAL SA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com