Active gene molecule nano cabin and its preparing method

Abstract

The present invention provides an active gene molecule nano cabin as one mechanically operated on-off tool in molecular level. The active gene molecule nano cabin consists of several gene molecule units arranged repeatedly, and each gene molecule unit includes one section of double strand away from the substrate and one section of single strand near the substrate. The single strand has one end fixed to the surface of the solid substrate. The double strands of the gene molecule units arrange closely to form one compact molecular membrane layer, so that one nano leve high molecular carbin is formed between the molecular membrane layer and the solid substrate. The preparation process of the nano molecular cabin is also provided.

Description

Technical field: [0001] The invention belongs to the technical field of molecular mechanical devices (Molecular Mechanical Device) based on gene molecules, and belongs to the cross technical field of physics and life science. Background technique: [0002] Molecular mechanical devices based on gene molecules are a cutting-edge technology that has only begun to appear in recent years. In the current technology, the most basic ones are single-function devices based on a few gene molecules, and there are two typical ones as follows: first, the mechanical rotation of 180 degrees is realized by using the B-Z helical structure conversion of DNA (reference: Chengde Mao, Weiqiong Sun, Zhiyong Shen & Nadrian C. Seeman. A nanomechanical device based on the B-Z transition of DNA. Nature, 397, (1999) 144-146); Second, the use of hybridization of DNA molecules and polymorphism of secondary structures Sexual realization of molecular clamp (reference: Bernard Yurke, et al. ADNA-fueled mol...

AI Technical Summary

Problems solved by technology

This type of DNA molecular device is characterized by a single function and stronger demonstration than practicality. That is to say, it shows the possibility of technical realization of mechanical manipulation at the nanoscale and molecular level, but does not provide Any methods and approaches available for practical application

The other type is an oligofunctional device based on a large number of gene molecules compared to the former, which was first designed by scientists such as Hao Yan in 2002 (references: HaoYan, Xiaoping Zhang, Zhiyong Shen & Nadrian C. Seeman. A robust DNA mechanicaldevices controlled by hybridization topology.Nature, 415, (2002) 62-65), this new type of molecular device is composed of multiple mechanical units repeatedly arranged, each mechanical unit through DNA double hybrid molecule (Double Crossover DNA) The conversion between two topological isomers is used to achieve mechanical rotation. Since the double-hybrid molecular mechanical unit can be extended repeatedly over a long distance, the mechanical rotation of the mechanical unit can trigger the mechanical transmission, thereby achieving multi-level nanoscale mechanical handling. However, , although the nanomechanical function of this molecular device has been demonstrated, the problem of how to use it to the actual application system has not been further solved, and this molecular device still has a large distance from practical application

[0003] In general, the research on molecular mechanical devices has just started in the world. On the one hand, the research is relatively preliminary and the experiments are not rich enough;

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